Search Results - "Robaa, Dina"

The Current State of NAD+‐Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets by Schiedel, Matthias, Robaa, Dina, Rumpf, Tobias, Sippl, Wolfgang, Jung, Manfred

“…Sirtuins are NAD+‐dependent protein deacylases that cleave off acetyl, as well as other acyl groups, from the ε‐amino group of lysines in histones and other…”
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Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals) by Schiedel, Matthias, Herp, Daniel, Hammelmann, Sören, Swyter, Sören, Lehotzky, Attila, Robaa, Dina, Oláh, Judit, Ovádi, Judit, Sippl, Wolfgang, Jung, Manfred

“…Here we report the development of a proteolysis targeting chimera (PROTAC) based on the combination of the unique features of the sirtuin rearranging ligands…”
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Comparative Structure-Based Virtual Screening Utilizing Optimized AlphaFold Model Identifies Selective HDAC11 Inhibitor by Baselious, Fady, Hilscher, Sebastian, Robaa, Dina, Barinka, Cyril, Schutkowski, Mike, Sippl, Wolfgang

“…HDAC11 is a class IV histone deacylase with no crystal structure reported so far. The catalytic domain of HDAC11 shares low sequence identity with other HDAC…”
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Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells by Plesch, Eva, Chen, Cheng-Chang, Butz, Elisabeth, Scotto Rosato, Anna, Krogsaeter, Einar K, Yinan, Hua, Bartel, Karin, Keller, Marco, Robaa, Dina, Teupser, Daniel, Holdt, Lesca M, Vollmar, Angelika M, Sippl, Wolfgang, Puertollano, Rosa, Medina, Diego, Biel, Martin, Wahl-Schott, Christian, Bracher, Franz, Grimm, Christian

“…Cytokines and chemokines are produced and secreted by a broad range of immune cells including macrophages. Remarkably, little is known about how these…”
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KATching-Up on Small Molecule Modulators of Lysine Acetyltransferases by Simon, Roman P, Robaa, Dina, Alhalabi, Zayan, Sippl, Wolfgang, Jung, Manfred

“…The reversible acetylation of lysines is one of the best characterized epigenetic modifications. Its involvement in many key physiological and pathological…”
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Exploring aromatic cage flexibility of the histone methyllysine reader protein Spindlin1 and its impact on binding mode prediction: an in silico study by Luise, Chiara, Robaa, Dina, Sippl, Wolfgang

“…Some of the main challenges faced in drug discovery are pocket flexibility and binding mode prediction. In this work, we explored the aromatic cage flexibility…”
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Muscle Carnitine Palmitoyltransferase II Deficiency: A Review of Enzymatic Controversy and Clinical Features by Lehmann, Diana, Motlagh, Leila, Robaa, Dina, Zierz, Stephan

“…CPT (carnitine palmitoyltransferase) II muscle deficiency is the most common form of muscle fatty acid metabolism disorders. In contrast to carnitine…”
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Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants by Marek, Martin, Shaik, Tajith B, Heimburg, Tino, Chakrabarti, Alokta, Lancelot, Julien, Ramos-Morales, Elizabeth, Da Veiga, Cyrielle, Kalinin, Dmitrii, Melesina, Jelena, Robaa, Dina, Schmidtkunz, Karin, Suzuki, Takayoshi, Holl, Ralph, Ennifar, Eric, Pierce, Raymond J, Jung, Manfred, Sippl, Wolfgang, Romier, Christophe

“…Metal-dependent histone deacetylases (HDACs) are key epigenetic regulators that represent promising therapeutic targets for the treatment of numerous human…”
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Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors by Vögerl, Katharina, Ong, Nghia, Senger, Johanna, Herp, Daniel, Schmidtkunz, Karin, Marek, Martin, Müller, Martin, Bartel, Karin, Shaik, Tajith B, Porter, Nicholas J, Robaa, Dina, Christianson, David W, Romier, Christophe, Sippl, Wolfgang, Jung, Manfred, Bracher, Franz

“…The phenothiazine system was identified as a favorable cap group for potent and selective histone deacetylase 6 (HDAC6) inhibitors. Here, we report the…”
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Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis by Heimburg, Tino, Chakrabarti, Alokta, Lancelot, Julien, Marek, Martin, Melesina, Jelena, Hauser, Alexander-Thomas, Shaik, Tajith B, Duclaud, Sylvie, Robaa, Dina, Erdmann, Frank, Schmidt, Matthias, Romier, Christophe, Pierce, Raymond J, Jung, Manfred, Sippl, Wolfgang

“…Schistosomiasis is a major neglected parasitic disease that affects more than 265 million people worldwide and for which the control strategy consists of mass…”
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Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity by Darwish, Salma, Ghazy, Ehab, Heimburg, Tino, Herp, Daniel, Zeyen, Patrik, Salem-Altintas, Rabia, Ridinger, Johannes, Robaa, Dina, Schmidtkunz, Karin, Erdmann, Frank, Schmidt, Matthias, Romier, Christophe, Jung, Manfred, Oehme, Ina, Sippl, Wolfgang

“…In addition to involvement in epigenetic gene regulation, histone deacetylases (HDACs) regulate multiple cellular processes through mediating the activity of…”
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Binding Free Energy (BFE) Calculations and Quantitative Structure-Activity Relationship (QSAR) Analysis of Schistosoma mansoni Histone Deacetylase 8 ( sm HDAC8) Inhibitors by Simoben, Conrad V, Ghazy, Ehab, Zeyen, Patrik, Darwish, Salma, Schmidt, Matthias, Romier, Christophe, Robaa, Dina, Sippl, Wolfgang

“…Histone-modifying proteins have been identified as promising targets to treat several diseases including cancer and parasitic ailments. methods have been…”
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Histone Deacetylase (HDAC) Inhibitors for the Treatment of Schistosomiasis by Ghazy, Ehab, Abdelsalam, Mohamed, Robaa, Dina, Pierce, Raymond J, Sippl, Wolfgang

“…Schistosomiasis is a major neglected parasitic disease that affects more than 240 million people worldwide and for which the control strategy consists of mass…”
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Mind the Methyl: Methyllysine Binding Proteins in Epigenetic Regulation by Wagner, Tobias, Robaa, Dina, Sippl, Wolfgang, Jung, Manfred

“…Epigenetics is defined as the phenomenon of heritable phenotypic traits that are not governed by alteration of the genetic code. Major epigenetic control…”
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Synthesis, Molecular Docking and Biological Characterization of Pyrazine Linked 2-Aminobenzamides as New Class I Selective Histone Deacetylase (HDAC) Inhibitors with Anti-Leukemic Activity by Ibrahim, Hany S, Abdelsalam, Mohamed, Zeyn, Yanira, Zessin, Matthes, Mustafa, Al-Hassan M, Fischer, Marten A, Zeyen, Patrik, Sun, Ping, Bülbül, Emre F, Vecchio, Anita, Erdmann, Frank, Schmidt, Matthias, Robaa, Dina, Barinka, Cyril, Romier, Christophe, Schutkowski, Mike, Krämer, Oliver H, Sippl, Wolfgang

“…Class I histone deacetylases (HDACs) are key regulators of cell proliferation and they are frequently dysregulated in cancer cells. We report here the…”
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Application of Ligand- and Structure-Based Prediction Models for the Design of Alkylhydrazide-Based HDAC3 Inhibitors as Novel Anti-Cancer Compounds by Bülbül, Emre F, Robaa, Dina, Sun, Ping, Mahmoudi, Fereshteh, Melesina, Jelena, Zessin, Matthes, Schutkowski, Mike, Sippl, Wolfgang

“…Histone deacetylases (HDAC) represent promising epigenetic targets for several diseases including different cancer types. The HDAC inhibitors approved to date…”
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Docking, Binding Free Energy Calculations and In Vitro Characterization of Pyrazine Linked 2-Aminobenzamides as Novel Class I Histone Deacetylase (HDAC) Inhibitors by Bülbül, Emre F, Melesina, Jelena, Ibrahim, Hany S, Abdelsalam, Mohamed, Vecchio, Anita, Robaa, Dina, Zessin, Matthes, Schutkowski, Mike, Sippl, Wolfgang

“…Class I histone deacetylases, HDAC1, HDAC2, and HDAC3, represent potential targets for cancer treatment. However, the development of isoform-selective drugs…”
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Structure-activity studies on N-Substituted tranylcypromine derivatives lead to selective inhibitors of lysine specific demethylase 1 (LSD1) and potent inducers of leukemic cell differentiation by Schulz-Fincke, Johannes, Hau, Mirjam, Barth, Jessica, Robaa, Dina, Willmann, Dominica, Kürner, Andreas, Haas, Julian, Greve, Gabriele, Haydn, Tinka, Fulda, Simone, Lübbert, Michael, Lüdeke, Steffen, Berg, Tobias, Sippl, Wolfgang, Schüle, Roland, Jung, Manfred

“…FAD-dependent lysine-specific demethylase 1 (LSD1) is overexpressed or deregulated in many cancers such as AML and prostate cancer and hence is a promising…”
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A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing by Simoben, Conrad V, Robaa, Dina, Chakrabarti, Alokta, Schmidtkunz, Karin, Marek, Martin, Lancelot, Julien, Kannan, Srinivasaraghavan, Melesina, Jelena, Shaik, Tajith B, Pierce, Raymond J, Romier, Christophe, Jung, Manfred, Sippl, Wolfgang

“…A promising means in the search of new small molecules for the treatment of schistosomiasis (amongst other parasitic ailments) is by targeting the parasitic…”
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Structure-Based Design, Docking and Binding Free Energy Calculations of A366 Derivatives as Spindlin1 Inhibitors by Luise, Chiara, Robaa, Dina, Regenass, Pierre, Maurer, David, Ostrovskyi, Dmytro, Seifert, Ludwig, Bacher, Johannes, Burgahn, Teresa, Wagner, Tobias, Seitz, Johannes, Greschik, Holger, Park, Kwang-Su, Xiong, Yan, Jin, Jian, Schüle, Roland, Breit, Bernhard, Jung, Manfred, Sippl, Wolfgang

“…The chromatin reader protein Spindlin1 plays an important role in epigenetic regulation, through which it has been linked to several types of malignant tumors…”
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