Search Results - "Roatt, Bruno Mendes"

Recent advances and new strategies on leishmaniasis treatment by Roatt, Bruno Mendes, de Oliveira Cardoso, Jamille Mirelle, De Brito, Rory Cristiane Fortes, Coura-Vital, Wendel, de Oliveira Aguiar-Soares, Rodrigo Dian, Reis, Alexandre Barbosa

“…Leishmaniasis is one of the most important tropical neglected diseases according to the World Health Organization. Even after more than a century, we still…”
Get full text

Recent advances and new strategies in Leishmaniasis diagnosis by De Brito, Rory Cristiane Fortes, Aguiar-Soares, Rodrigo Dian de Oliveira, Cardoso, Jamille Mirelle de Oliveira, Coura-Vital, Wendel, Roatt, Bruno Mendes, Reis, Alexandre Barbosa

“…Leishmaniasis is a set of complex and multifaceted syndromes, with different clinical manifestations, caused by different species of the genus Leishmania spp…”
Get full text

Development of a topical treatment for tegumentary leishmaniasis using 8-hydroxyquinoline by Rezende Ribeiro, Naianda, Magno Oliveira Santos, Lucas, Silva Costa, Scarleth, Kei Myasaki, Carolina, Pagliara Lage, Daniela, Tamietti Martins, Vivian, Cristiane Fortes De Brito, Rory, Chaves Freire, Larissa, Maria Ravena Severino Carvalho, Ana, Victor Serafim Brigido, Bryan, José Alves, Ricardo, Antonio Ferraz Coelho, Eduardo, Mendes Roatt, Bruno, Menezes-Souza, Daniel, Costa Duarte, Mariana

“…[Display omitted] •A treatment that used the topical route as an alternative to treatment for tegumentary leishmaniasis.•8-hydroxyquinoline (8-HQN) was…”
Get full text

CD4+ and CD8+ T-cell multi-epitope chimeric protein associated with an MPLA adjuvant induce protective efficacy and long-term immunological memory for the immunoprophylaxis of American Tegumentary Leishmaniasis by Moura, Dênia Monteiro de, Carvalho, Ana Maria Ravena Severino, Brito, Rory Cristiane Fortes de, Roatt, Bruno Mendes, Lage, Daniela Pagliara, Martins, Vivian Tamietti, Cruz, Luiza dos Reis, Medeiros, Fernanda Alvarenga Cardoso, Batista, Sarah Dutra, Pinheiro, Guilherme Rafael Gomide, da Costa Rocha, Manoel Otávio, Coelho, Eduardo Antonio Ferraz, Duarte, Mariana Costa, Mendes, Tiago Antônio de Oliveira, Menezes-Souza, Daniel

“…American Tegumentary Leishmaniasis (ATL) is a disease of high severity and incidence in Brazil, in addition to being a worldwide concern in public health…”
Get full text

A chimeric vaccine combined with adjuvant system induces immunogenicity and protection against visceral leishmaniasis in BALB/c mice by Ostolin, Thais Lopes Valentim Di Paschoale, Gusmão, Miriã Rodrigues, Mathias, Fernando Augusto Siqueira, Cardoso, Jamille Mirelle de Oliveira, Roatt, Bruno Mendes, Aguiar-Soares, Rodrigo Dian de Oliveira, Ruiz, Jeronimo Conceição, Resende, Daniela de Melo, de Brito, Rory Cristiane Fortes, Reis, Alexandre Barbosa

“…In Brazil, canine visceral leishmaniasis is an important public health problem due to its alarming growth. The high prevalence of infected dogs reinforces the…”
Get full text

A specific Leishmania infantum polyepitope vaccine triggers Th1-type immune response and protects against experimental visceral leishmaniasis by Lopes Valentim Di Paschoale Ostolin, Thais, Rodrigues Gusmão, Miriã, Augusto Siqueira Mathias, Fernando, Mirelle de Oliveira Cardoso, Jamille, Mendes Roatt, Bruno, Dian de Oliveira Aguiar-Soares, Rodrigo, Conceição Ruiz, Jeronimo, de Melo Resende, Daniela, Cristiane Fortes de Brito, Rory, Barbosa Reis, Alexandre

Get full text

Immunoprophylaxis using polypeptide chimera vaccines plus adjuvant system promote Th1 response controlling the spleen parasitism in hamster model of visceral leishmaniasis by Gusmão, Miriã Rodrigues, Ostolin, Thaís Lopes Valentim Di Paschoali, Carvalho, Lívia Mendes, Costa, Ana Flávia Pereira, Moreira, Gabriel José Lucas, Cardoso, Jamille Mirelle de Oliveira, Aguiar-Soares, Rodrigo Dian de Oliveira, Reis, Alexandre Barbosa, de Brito, Rory Cristiane Fortes, Roatt, Bruno Mendes

“…In recent years, several advances have been observed in vaccinology especially for neglected tropical diseases (NTDs). One of the tools employed is epitope…”
Get full text

Immunochemotherapy for visceral leishmaniasis: combinatorial action of Miltefosine plus LBSapMPL vaccine improves adaptative Th1 immune response with control of splenic parasitism in experimental hamster model by Carvalho, Lívia Mendes, Gusmão, Miriã Rodrigues, Costa, Ana Flávia Pereira, de Brito, Rory Cristiane Fortes, Aguiar-Soares, Rodrigo Dian de Oliveira, Cardoso, Jamille Mirelle de Oliveira, Reis, Alexandre Barbosa, Carneiro, Cláudia Martins, Roatt, Bruno Mendes

“…The control of human visceral leishmaniasis (VL) is hard since there are no vaccines available as well as the treatment is hampered by toxicity and resistant…”
Get full text

Prevalence and factors associated with Leishmania infantum infection of dogs from an urban area of Brazil as identified by molecular methods by Coura-Vital, Wendel, Marques, Marcos José, Veloso, Vanja Maria, Roatt, Bruno Mendes, Aguiar-Soares, Rodrigo Dian de Oliveira, Reis, Levi Eduardo Soares, Braga, Samuel Leôncio, Morais, Maria Helena Franco, Reis, Alexandre Barbosa, Carneiro, Mariângela

“…Various factors contribute to the urbanization of the visceral leishmaniasis (VL), including the difficulties of implementing control measures relating to the…”
Get full text

Immunotherapy Combining Mimotopes Selected by Phage Display Plus Amphotericin B Is Effective for Treatment Against Visceral Leishmaniasis by Soyer, Tauane Gonçalves, Bandeira Câmara, Raquel Soares, Pereira, Isabela Amorim Gonçalves, Ramos, Fernanda Fonseca, Jesus, Marcelo Moreira, Ludolf, Fernanda, Paula Costa, Guilherme, Lage, Daniela Pagliara, Freitas, Camila Simões, Vale, Danniele Luciana, Pimenta, Breno Luiz, Martins, Vívian Tamietti, Galdino, Alexsandro Sobreira, Chávez‐Fumagalli, Miguel Angel, Roatt, Bruno Mendes, Sousa Vieira Tavares, Grasiele, Coelho, Eduardo Antonio Ferraz

“…ABSTRACT The treatment for visceral leishmaniasis (VL) causes toxicity in patients, entails high cost and/or leads to the emergence of resistant strains. No…”
Get full text

Establishment of monoclonal antibodies to evaluate the cellular immunity in a hamster model of L infantum infection by Carvalho, Lívia Mendes, Brito, Rory Cristiane Fortes, Gusmão, Miriã Rodrigues, Oliveira Aguiar‐Soares, Rodrigo Dian, Reis, Alexandre Barbosa, Roatt, Bruno Mendes

“…Syrian hamsters (Mesocricetus auratus) are largely used as a model for infectious diseases because it is very susceptible to several pathogens, including…”
Get full text

Evaluation of change in canine diagnosis protocol adopted by the visceral leishmaniasis control program in Brazil and a new proposal for diagnosis by Coura-Vital, Wendel, Ker, Henrique Gama, Roatt, Bruno Mendes, Aguiar-Soares, Rodrigo Dian Oliveira, Leal, Gleisiane Gomes de Almeida, Moreira, Nádia das Dores, Oliveira, Laser Antônio Machado, de Menezes Machado, Evandro Marques, Morais, Maria Helena Franco, Corrêa-Oliveira, Rodrigo, Carneiro, Mariângela, Reis, Alexandre Barbosa

“…The techniques used for diagnosis of canine visceral leishmaniasis (CVL) in Brazil ELISA and IFAT have been extensively questioned because of the accuracy of…”
Get full text

Effect on cellular recruitment and the innate immune response by combining saponin, monophosphoryl lipid-A and Incomplete Freund’s Adjuvant with Leishmania (Viannia) braziliensis antigens for a vaccine formulation by Vitoriano-Souza, Juliana, Siqueira Mathias, Fernando Augusto, Moreira, Nádia das Dores, Aguiar-Soares, Rodrigo Dian de Oliveira, de Abreu Vieira, Paula Melo, Teixeira-Carvalho, Andréa, Carneiro, Cláudia Martins, Giunchetti, Rodolfo Cordeiro, de Brito, Rory Cristiane Fortes, Fujiwara, Ricardo Toshio, Roatt, Bruno Mendes, Melo, Maria Norma, Reis, Alexandre Barbosa

“…The poor immunogenicity displayed by some antigens has encouraged the development of strategies to improve the immune response and safety of vaccine…”
Get full text

Recent updates and perspectives on approaches for the development of vaccines against visceral leishmaniasis by Duarte, Mariana Costa, Lage, Daniela Pagliara, Martins, Vívian Tamietti, Chávez-Fumagalli, Miguel Angel, Roatt, Bruno Mendes, Menezes-Souza, Daniel, Goulart, Luiz Ricardo, Soto, Manuel, Tavares, Carlos Alberto Pereira, Coelho, Eduardo Antonio Ferraz

“…Visceral leishmaniasis (VL) is one of the most important tropical diseases worldwide. Although chemotherapy has been widely used to treat this disease,…”
Get full text

Immunotherapy and Immunochemotherapy in Visceral Leishmaniasis: Promising Treatments for this Neglected Disease by Roatt, Bruno Mendes, Aguiar-Soares, Rodrigo Dian de Oliveira, Coura-Vital, Wendel, Ker, Henrique Gama, Moreira, Nádia das Dores, Vitoriano-Souza, Juliana, Giunchetti, Rodolfo Cordeiro, Carneiro, Cláudia Martins, Reis, Alexandre Barbosa

“…self-healing or chronic cutaneous leishmaniasis or post-kala-azar dermal leishmaniasis; mucosal leishmaniasis; visceral leishmaniasis (VL), which is fatal if…”
Get full text

Parasite burden in hamsters infected with two different strains of leishmania (Leishmania) infantum: "Leishman Donovan units" versus real-time PCR by Moreira, Nádia das Dores, Vitoriano-Souza, Juliana, Roatt, Bruno Mendes, Vieira, Paula Melo de Abreu, Ker, Henrique Gama, de Oliveira Cardoso, Jamille Mirelle, Giunchetti, Rodolfo Cordeiro, Carneiro, Cláudia Martins, de Lana, Marta, Reis, Alexandre Barbosa

“…To develop and test new therapeutics and immune prophylaxis strategies for visceral leishmaniasis (VL), understanding tissue parasitism evolution after…”
Get full text

Treatment of murine visceral leishmaniasis using an 8-hydroxyquinoline-containing polymeric micelle system by Duarte, Mariana Costa, Lage, Letícia Martins dos Reis, Lage, Daniela Pagliara, Martins, Vívian Tamietti, Carvalho, Ana Maria Ravena Severino, Roatt, Bruno Mendes, Menezes-Souza, Daniel, Tavares, Carlos Alberto Pereira, Alves, Ricardo José, Barichello, José Mário, Coelho, Eduardo Antonio Ferraz

“…Abstract New therapeutics are urgently needed to treat visceral leishmaniasis (VL). Due to the fact that drug discovery is a long and expensive process, the…”
Get full text

Clinical forms of canine visceral Leishmaniasis in naturally Leishmania infantum-infected dogs and related myelogram and hemogram changes by Nicolato, Roney de Carvalho, de Abreu, Raquel Trópia, Roatt, Bruno Mendes, Aguiar-Soares, Rodrigo Dian de Oliveira, Reis, Levi Eduardo Soares, Carvalho, Maria das Graças, Carneiro, Cláudia Martins, Giunchetti, Rodolfo Cordeiro, Bouillet, Leoneide Erica Maduro, Lemos, Denise Silveira, Coura-Vital, Wendel, Reis, Alexandre Barbosa

“…Hematological analysis has limited applications for disease diagnosis in Leishmania infantum-infected dogs, but it can be very important in evaluating the…”
Get full text

An 8-hydroxyquinoline-containing polymeric micelle system is effective for the treatment of murine tegumentary leishmaniasis by Lage, Letícia Martins dos Reis, Barichello, José Mário, Lage, Daniela Pagliara, Mendonça, Débora Vasconcelos Costa, Carvalho, Ana Maria Ravena Severino, Rodrigues, Marcella Rezende, Menezes-Souza, Daniel, Roatt, Bruno Mendes, Alves, Ricardo José, Tavares, Carlos Alberto Pereira, Coelho, Eduardo Antonio Ferraz, Duarte, Mariana Costa

“…The current treatment of leishmaniasis has been hampered due to the high toxicity of the available drugs and long duration protocols, which often lead to its…”
Get full text

Comparative analysis of real-time PCR assays in the detection of canine visceral leishmaniasis by Nunes, Juliana Barbosa, Coura-Vital, Wendel, Colombo, Fabio Antônio, Baêta, Frederico José Moreira, Pinheiro, Aimara Costa, Roatt, Bruno Mendes, Reis, Levi Eduardo Soares, Reis, Alexandre Barbosa, Marques, Marcos José

“…Dogs are important hosts and reservoirs of leishmaniasis, a disease caused by protozoan parasites from the genus Leishmania, affecting ~12 million people…”
Get full text