Search Results - "Roach, Claudia"

Aldolase provides an unusual binding site for thrombospondin-related anonymous protein in the invasion machinery of the malaria parasite by Bosch, Jürgen, Buscaglia, Carlos A, Krumm, Brian, Ingason, Bjarni P, Lucas, Robert, Roach, Claudia, Cardozo, Timothy, Nussenzweig, Victor, Hol, Wim G.J

“…An actomyosin motor located underneath the plasma membrane drives motility and host-cell invasion of apicomplexan parasites such as Plasmodium falciparum and…”
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The Closed MTIP-Myosin A-Tail Complex from the Malaria Parasite Invasion Machinery by Bosch, Jürgen, Turley, Stewart, Roach, Claudia M., Daly, Thomas M., Bergman, Lawrence W., Hol, Wim G.J.

“…The Myosin A-tail interacting protein (MTIP) of the malaria parasite links the actomyosin motor of the host cell invasion machinery to its inner membrane…”
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Structure of the MTIP-MyoA Complex, a Key Component of the Malaria Parasite Invasion Motor by Bosch, Jürgen, Turley, Stewart, Daly, Thomas M., Bogh, Stephen M., Villasmil, Michelle L., Roach, Claudia, Zhou, Na, Morrisey, Joanne M., Vaidya, Akhil B., Bergman, Lawrence W., Hol, Wim G. J.

“…The causative agents of malaria have developed a sophisticated machinery for entering multiple cell types in the human and insect hosts. In this machinery, a…”
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Analysis of the Sequence Motifs Responsible for the Interactions of Peroxins 14 and 5, Which Are Involved in Glycosome Biogenesis in Trypanosoma brucei by Choe, Jungwoo, Moyersoen, Juliette, Roach, Claudia, Carter, Tyan L, Fan, Erkang, Michels, Paul A. M, Hol, Wim G. J

“…Glycosome biogenesis in trypanosomatids occurs via a process that is homologous to peroxisome biogenesis in other eukaryotes. Glycosomal matrix proteins are…”
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An unexpected extended conformation for the third TPR motif of the peroxin PEX5 from Trypanosoma brucei by Kumar, Abhinav, Roach, Claudia, Hirsh, Irwin S, Turley, Stewart, deWalque, Stéphane, Michels, Paul A.M, Hol, Wim G.J

“…A number of helix-rich protein motifs are involved in a variety of critical protein-protein interactions in living cells. One of these is the tetratrico…”
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Structural Insights into the Recognition of Peroxisomal Targeting Signal 1 by Trypanosoma brucei Peroxin 5 by Sampathkumar, Parthasarathy, Roach, Claudia, Michels, Paul A.M., Hol, Wim G.J.

“…Glycosomes are peroxisome-like organelles essential for trypanosomatid parasites. Glycosome biogenesis is mediated by proteins called “peroxins,” which are…”
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Lovastatin biosynthesis in Aspergillus terreus: Characterization of blocked mutants, enzyme activities and a multifunctional polyketide synthase gene by Hendrickson, Lee, Ray Davis, C, Roach, Claudia, Kim Nguyen, Di, Aldrich, Teri, McAda, Phyllis C, Reeves, Christopher D

“…Lovastatin, an HMG-CoA reductase inhibitor produced by the fungus Aspergillus terreus, is composed of two polyketide chains. One is a nonaketide that undergoes…”
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Solution and Crystallographic Studies of Branched Multivalent Ligands that Inhibit the Receptor-Binding of Cholera Toxin by Zhang, Zhongsheng, Merritt, Ethan A, Ahn, Misol, Roach, Claudia, Hou, Zheng, Verlinde, Christophe L. M. J, Hol, Wim G. J, Fan, Erkang

“…The structure-based design of multivalent ligands offers an attractive strategy toward high affinity protein inhibitors. The spatial arrangement of the…”
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Mutants of Streptomyces cattleya defective in the synthesis of a factor required for thienamycin production by Buchan, T, Roach, C, Ruby, C, Taylor, D, Preisig, C, Reeves, C

“…Thienamycin non-producing mutants of Streptomydes cattleya were identified that displayed a cross-feeding relationship. A diffusible product from one of these…”
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Crystal Structures, Metal Activation, and DNA-Binding Properties of Two-Domain IdeR from Mycobacterium tuberculosis by Wisedchaisri, Goragot, Chou, C. James, Wu, Meiting, Roach, Claudia, Rice, Adrian E, Holmes, Randall K, Beeson, Craig, Hol, Wim G. J

“…The iron-dependent regulator IdeR is a key transcriptional regulator of iron uptake in Mycobacterium tuberculosis. In order to increase our insight into the…”
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Structure-Based Exploration of the Ganglioside GM1 Binding Sites of Escherichia coli Heat-Labile Enterotoxin and Cholera Toxin for the Discovery of Receptor Antagonists by Minke, Wendy E, Roach, Claudia, Hol, Wim G. J, Verlinde, Christophe L. M. J

“…Ganglioside GM1 is the natural receptor for cholera toxin (CT) and heat-labile enterotoxin (LT), which are the causative agents of cholera and traveler's…”
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The closed MTIP-MyosinA-tail complex from the malaria parasite invasion machinery by Bosch, Jürgen, Turley, Stewart, Roach, Claudia M., Daly, Thomas M., Bergman, Lawrence W., Hol, Wim G. J.

“…The Myosin A-tail Interacting Protein (MTIP) of the malaria parasite links the actomyosin motor of the host cell invasion machinery to its inner membrane…”
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Structural biology and structure-based inhibitor design of cholera toxin and heat-labile enterotoxin by Fan, Erkang, O’Neal, Claire J., Mitchell, Daniel D., Robien, Mark A., Zhang, Zhongsheng, Pickens, Jason C., Tan, Xiao-Jian, Korotkov, Konstantin, Roach, Claudia, Krumm, Brian, Verlinde, Christophe L.M.J., Merritt, Ethan A., Hol, Wim G.J.

“…Structural biology studies on cholera toxin and the closely related heat-labile enterotoxin from enterotoxigenic Escherichia coli over the past decade have…”
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Exploration of the GM1 receptor-binding site of heat-labile enterotoxin and cholera toxin by phenyl-ring-containing galactose derivatives by Fan, Erkang, Merritt, Ethan A., Zhang, Zhongsheng, Pickens, Jason C., Roach, Claudia, Ahn, Misol, Hol, Wim G. J.

“…Cholera toxin (CT) and the closely related heat‐labile enterotoxin of Escherichia coli (LT) are responsible for numerous cases of diarrhea worldwide, leading…”
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