Search Results - "Roach, Arthur"

Neuroprotection by safinamide in the 6-hydroxydopamine model of Parkinson's disease by Sadeghian, Mona, Mullali, Gizem, Pocock, Jennifer M., Piers, Thomas, Roach, Arthur, Smith, Kenneth J.

“…Aims Current therapies in Parkinson's disease mainly treat symptoms rather than provide effective neuroprotection. We examined the effects of safinamide…”
Get full text

Tremorolytic effects of safinamide in animal models of drug-induced parkinsonian tremor by Podurgiel, Samantha, Collins-Praino, Lyndsey E., Yohn, Samantha, Randall, Patrick A., Roach, Arthur, Lobianco, Christophe, Salamone, John D.

“…Safinamide is an α-aminoamide derivative that is currently in Phase III clinical trial development as an add-on therapy to levodopa or dopamine agonists for…”
Get full text

Molecular Neuroimaging of the Dopamine Transporter as a Patient Enrichment Biomarker for Clinical Trials for Early Parkinson's Disease by Romero, Klaus, Conrado, Daniela, Burton, Jackson, Nicholas, Timothy, Sinha, Vikram, Macha, Sreeraj, Ahamadi, Malidi, Cedarbaum, Jesse, Seibyl, John, Marek, Kenneth, Basseches, Peter, Hill, Derek, Somer, Ed, Gallagher, Jill, Dexter, David T., Roach, Arthur, Stephenson, Diane

“…The Critical Path for Parkinson's (CPP) Imaging Biomarker and Modeling and Simulation working groups aimed to achieve qualification opinion by the European…”
Get full text

The Amyloid-β Rise and γ-Secretase Inhibitor Potency Depend on the Level of Substrate Expression by Burton, Catherine R., Meredith, Jere E., Barten, Donna M., Goldstein, Margi E., Krause, Carol M., Kieras, Cathy J., Sisk, Lisa, Iben, Lawrence G., Polson, Craig, Thompson, Mark W., Lin, Xu-Alan, Corsa, Jason, Fiedler, Tracey, Pierdomenico, Maria, Cao, Yang, Roach, Arthur H., Cantone, Joseph L., Ford, Michael J., Drexler, Dieter M., Olson, Richard E., Yang, Michael G., Bergstrom, Carl P., McElhone, Kate E., Bronson, Joanne J., Macor, John E., Blat, Yuval, Grafstrom, Robert H., Stern, Andrew M., Seiffert, Dietmar A., Zaczek, Robert, Albright, Charles F., Toyn, Jeremy H.

“…The amyloid-β (Aβ) peptide, which likely plays a key role in Alzheimer disease, is derived from the amyloid-β precursor protein (APP) through consecutive…”
Get full text

Targeted Disruption of the Murine Bin1/Amphiphysin II Gene Does Not Disable Endocytosis but Results in Embryonic Cardiomyopathy with Aberrant Myofibril Formation by Muller, Alexander J., Baker, Judith F., DuHadaway, James B., Ge, Kai, Farmer, George, Donover, P. Scott, Meade, Raymond, Reid, Christian, Grzanna, Reinhard, Roach, Arthur H., Shah, Neelima, Soler, Alejandro Peralta, Prendergast, George C.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Identification and Characterization of Presenilin-independent Notch Signaling by Berechid, Bridget E., Kitzmann, Magali, Foltz, Daniel R., Roach, Arthur H., Seiffert, Dietmar, Thompson, Lorin A., Olson, Richard E., Bernstein, Alan, Donoviel, Dorit B., Nye, Jeffrey S.

“…Presenilin (PS) proteins control the proteolytic cleavage that precedes nuclear access of the Notch intracellular domain. Here we observe that a partial…”
Get full text

Design and synthesis of benzoazepinone-derived cyclic malonamides and aminoamides as potent γ-secretase inhibitors by Yang, Michael G., Shi, Jian-Liang, Modi, Dilip P., Wells, Jennifer, Cochran, Brian M., Wolf, Mark A., Thompson, Lorin A., Ramanjulu, Mercy M., Roach, Arthur H., Zaczek, Robert, Robertson, David W., Wexler, Ruth R., Olson, Richard E.

“…Compounds such as 2h (APP IC 50 = 5.8 nM) and 3l (APP IC 50 = 4.2 nM) are potent γ-secretase inhibitors. We report the synthesis of benzoazepine-derived cyclic…”
Get full text

Synthesis and evaluation of succinoyl-caprolactam γ-secretase inhibitors by Thompson, Lorin A., Liauw, Ann Y., Ramanjulu, Mercy M., Kasireddy-Polam, Padmaja, Mercer, Stephen E., Maduskuie, Thomas P., Glicksman, Marcie, Roach, Arthur H., Meredith, Jere E., Liu, Rui-Qin, Combs, Andrew P., Higaki, Jeffrey N., Cordell, Barbara, Seiffert, Dietmar, Zaczek, Robert C., Robertson, David W., Olson, Richard E.

“…The synthesis, evaluation, and structure–activity relationships of a series of succinoyl lactam inhibitors of the Alzheimer’s disease γ-secretase are…”
Get full text

Safinamide reduces dyskinesias and prolongs l -DOPA antiparkinsonian effect in parkinsonian monkeys by Grégoire, Laurent, Jourdain, Vincent A, Townsend, Matthew, Roach, Arthur, Di Paolo, Thérèse

“…Abstract Introduction Safinamide is a compound under investigation for use in the treatment of Parkinson's disease for combination with pharmacological therapy…”
Get full text

Safinamide and flecainide protect axons and reduce microglial activation in models of multiple sclerosis by MORSALI, Damineh, BECHTOLD, David, ROACH, Arthur, SMITH, Kenneth J, LEE, Woojin, CHAUHDRY, Summen, PALCHAUDHURI, Upayan, HASSOON, Paula, SNELL, Daniel M, MALPASS, Katy, PIERS, Thomas, POCOCK, Jennifer

“…Axonal degeneration is a major cause of permanent disability in the inflammatory demyelinating disease multiple sclerosis, but no therapies are known to be…”
Get full text

Characterization of cloned cDNA representing rat myelin basic protein: absence of expression in brain of shiverer mutant mice by Roach, A, Boylan, K, Horvath, S, Prusiner, S B, Hood, L E

“…A cDNA library was constructed from mRNA isolated from the brains of 18-day-old rats, the age at which myelin biosynthesis is maximal. A synthetic DNA probe…”
Get more information

Neuroprotection by safinamide in the 6‐hydroxydopamine model of P arkinson's disease by Sadeghian, Mona, Mullali, Gizem, Pocock, Jennifer M., Piers, Thomas, Roach, Arthur, Smith, Kenneth J.

Get full text

In vitro and in vivo pharmacological profile of AS057278, a selective d -amino acid oxidase inhibitor with potential anti-psychotic properties by Adage, Tiziana, Trillat, Anne-Cécile, Quattropani, Anna, Perrin, Dominique, Cavarec, Laurent, Shaw, Jeffrey, Guerassimenko, Oxana, Giachetti, Claudio, Gréco, Béatrice, Chumakov, Ilya, Halazy, Serge, Roach, Arthur, Zaratin, Paola

“…Abstract Non-competitive N -methyl- d -aspartate (NMDA) blockers induce schizophrenic-like behavior in healthy volunteers and exacerbate symptomatology in…”
Get full text

Biochemistry of Information Storage in the Nervous System by Black, Ira B., Adler, Joshua E., Dreyfus, Cheryl F., Friedman, Wilma F., LaGamma, Edmund F., Roach, Arthur H.

“…The use of molecular biological approaches has defined new mechanisms that store information in the mammalian nervous system. Environmental stimuli alter…”
Get full text

Chemical inducers and transcriptional markers of oligodendrocyte differentiation by Joubert, Lara, Foucault, Isabelle, Sagot, Yves, Bernasconi, Lilia, Duval, François, Alliod, Chantal, Frossard, Marie-José, Pescini Gobert, Rosanna, Curchod, Marie-Laure, Salvat, Catherine, Nichols, Anthony, Pouly, Sandrine, Rommel, Christian, Roach, Arthur, Hooft van Huijsduijnen, Rob

“…Oligodendrocytes generate and maintain myelin, which is essential for axonal function and protection of the mammalian central nervous system. To advance our…”
Get full text

Coming out to mom and dad: a study of gay males and their relationships with their parents by Cramer, D W, Roach, A J

“…This study explores the relationship between gay men coming out to parents and specific perceived parental variables in an attempt to discriminate between…”
Get more information

Presenilin-1 and -2 Are Molecular Targets for γ-Secretase Inhibitors by Seiffert, Dietmar, Bradley, Jodi D., Rominger, Cynthia M., Rominger, David H., Yang, Fude, Meredith, Jere E., Wang, Qian, Roach, Arthur H., Thompson, Lorin A., Spitz, Susan M., Higaki, Jeffrey N., Prakash, Shimoga R., Combs, Andrew P., Copeland, Robert A., Arneric, Stephen P., Hartig, Paul R., Robertson, David W., Cordell, Barbara, Stern, Andrew M., Olson, Richard E., Zaczek, Robert

“…Presenilins are integral membrane protein involved in the production of amyloid β-protein. Mutations of the presenilin-1 and -2 gene are associated with…”
Get full text

The Marital Satisfaction Scale: Development of a Measure for Intervention Research by Roach, Arthur J., Frazier, Larry P., Bowden, Sharon R.

“…This study reviews the development of the Marital Satisfaction Scale (MSS). The MSS was designed to assess one's level of satisfaction toward his or her own…”
Get full text

Interfacial nucleic acid hybridization studied by random primer (32)P labeling and liquid-phase acoustic network analysis by Su, Hongbo, Kallury, Krishna M R, Thompson, Michael, Roach, Arthur

“…Single-strand DNA labeled with 32phosphorus by the random primer method has been adsorbed to the surface of palladium electrodes of thickness shear-mode…”
Get full text

Interpersonal communication skills differentiating more satisfying from less satisfying marital relationships by Boyd, Lenore A, Roach, Arthur J

“…In this study 25 statements representing specific communication skills were derived from a review of the literature and arranged as 2 scales: Interpersonal…”
Get full text