Search Results - "Römer, Winfried"

Lipid self-assembly and lectin-induced reorganization of the plasma membrane by Sych, Taras, Mély, Yves, Römer, Winfried

“…The plasma membrane represents an outstanding example of self-organization in biology. It plays a vital role in protecting the integrity of the cell interior…”
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Multiscale Molecular Dynamics Studies Reveal Different Modes of Receptor Clustering by Gb3-Binding Lectins by Kociurzynski, Raisa, Makshakova, Olga N, Knecht, Volker, Römer, Winfried

“…The recognition of carbohydrate receptors on host cell membranes by pathogenic lectins is a crucial step in the microbial invasion. Two bacterial lectins, the…”
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The Gb3-enriched CD59/flotillin plasma membrane domain regulates host cell invasion by Pseudomonas aeruginosa by Brandel, Annette, Aigal, Sahaja, Lagies, Simon, Schlimpert, Manuel, Meléndez, Ana Valeria, Xu, Maokai, Lehmann, Anika, Hummel, Daniel, Fisch, Daniel, Madl, Josef, Eierhoff, Thorsten, Kammerer, Bernd, Römer, Winfried

“…The opportunistic pathogen Pseudomonas aeruginosa has gained precedence over the years due to its ability to develop resistance to existing antibiotics,…”
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Thermal fluctuations of the lipid membrane determine particle uptake into Giant Unilamellar Vesicles by Ayala, Yareni A., Omidvar, Ramin, Römer, Winfried, Rohrbach, Alexander

“…Phagocytic particle uptake is crucial for the fate of both living cells and pathogens. Invading particles have to overcome fluctuating lipid membranes as the…”
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Photoreductive Uncaging of Fluorophore in Response to Protein Oligomers by Templated Reaction in Vitro and in Cellulo by Sadhu, Kalyan K, Eierhoff, Thorsten, Römer, Winfried, Winssinger, Nicolas

“…The photoreduction of azide-based immolative linker by Ru(II) conjugates to uncage rhodamine was achieved using different oligomeric protein templates. The…”
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100 Hz ROCS microscopy correlated with fluorescence reveals cellular dynamics on different spatiotemporal scales by Jünger, Felix, Ruh, Dominic, Strobel, Dominik, Michiels, Rebecca, Huber, Dominik, Brandel, Annette, Madl, Josef, Gavrilov, Alina, Mihlan, Michael, Daller, Caterina Cora, Rog-Zielinska, Eva A., Römer, Winfried, Lämmermann, Tim, Rohrbach, Alexander

“…Fluorescence techniques dominate the field of live-cell microscopy, but bleaching and motion blur from too long integration times limit dynamic investigations…”
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Lectin-mediated protocell crosslinking to mimic cell-cell junctions and adhesion by Villringer, Sarah, Madl, Josef, Sych, Taras, Manner, Christina, Imberty, Anne, Römer, Winfried

“…Cell adhesion is a crucial feature of all multicellular organisms, as it allows cells to organise themselves into tissues to carry out specific functions…”
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Injury-Driven Stiffening of the Dermis Expedites Skin Carcinoma Progression by Mittapalli, Venugopal R, Madl, Josef, Löffek, Stefanie, Kiritsi, Dimitra, Kern, Johannes S, Römer, Winfried, Nyström, Alexander, Bruckner-Tuderman, Leena

“…Recessive dystrophic epidermolysis bullosa (RDEB) is a genetic skin fragility disorder characterized by injury-driven blister formation, progressive…”
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Structural Diversities of Lectins Binding to the Glycosphingolipid Gb3 by Siukstaite, Lina, Imberty, Anne, Römer, Winfried

“…Glycolipids are present on the surfaces of all living cells and thereby represent targets for many protein receptors, such as lectins. Understanding the…”
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Glycans in autophagy, endocytosis and lysosomal functions by Reggiori, Fulvio, Gabius, Hans-Joachim, Aureli, Massimo, Römer, Winfried, Sonnino, Sandro, Eskelinen, Eeva-Liisa

“…Glycans have been shown to function as versatile molecular signals in cells. This prompted us to look at their roles in endocytosis, endolysosomal system and…”
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Actin Dynamics Drive Membrane Reorganization and Scission in Clathrin-Independent Endocytosis by Römer, Winfried, Pontani, Léa-Laetitia, Sorre, Benoît, Rentero, Carles, Berland, Ludwig, Chambon, Valérie, Lamaze, Christophe, Bassereau, Patricia, Sykes, Cécile, Gaus, Katharina, Johannes, Ludger

“…Nascent transport intermediates detach from donor membranes by scission. This process can take place in the absence of dynamin, notably in clathrin-independent…”
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Pathways of protein and lipid receptor-mediated transcytosis in drug delivery by Thuenauer, Roland, Müller, Stefan K, Römer, Winfried

“…A critical factor for the efficacy of drugs is their availability at the site of interest. However, crossing endothelial and epithelial cell layers like the…”
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Binding of SV40’s Viral Capsid Protein VP1 to Its Glycosphingolipid Receptor GM1 Induces Negative Membrane Curvature: A Molecular Dynamics Study by Kociurzynski, Raisa, Beck, Sophie D, Bouhon, Jean-Baptiste, Römer, Winfried, Knecht, Volker

“…The binding of the pentameric capsid protein VP1 of simian virus 40 to its glycosphingolipid receptor GM1 is a key step for the entry of the virus into the…”
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A Chlamydia pneumoniae adhesin induces phosphatidylserine exposure on host cells by Galle, Jan N., Fechtner, Tim, Eierhoff, Thorsten, Römer, Winfried, Hegemann, Johannes H.

“…In mammalian cells, the internal and external leaflets of the plasma membrane (PM) possess different phospholipids. Phosphatidylserine (PS) is normally…”
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Red Light-Regulated Reversible Nuclear Localization of Proteins in Mammalian Cells and Zebrafish by Beyer, Hannes M, Juillot, Samuel, Herbst, Kathrin, Samodelov, Sophia L, Müller, Konrad, Schamel, Wolfgang W, Römer, Winfried, Schäfer, Eberhard, Nagy, Ferenc, Strähle, Uwe, Weber, Wilfried, Zurbriggen, Matias D

“…Protein trafficking in and out of the nucleus represents a key step in controlling cell fate and function. Here we report the development of a red…”
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A bispecific, crosslinking lectibody activates cytotoxic T cells and induces cancer cell death by Rosato, Francesca, Pasupuleti, Rajeev, Tomisch, Jana, Meléndez, Ana Valeria, Kolanovic, Dajana, Makshakova, Olga N, Wiltschi, Birgit, Römer, Winfried

“…Aberrant glycosylation patterns play a crucial role in the development of cancer cells as they promote tumor growth and aggressiveness. Lectins recognize…”
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The Pseudomonas aeruginosa Lectin LecB Causes Integrin Internalization and Inhibits Epithelial Wound Healing by Thuenauer, Roland, Landi, Alessia, Trefzer, Anne, Altmann, Silke, Wehrum, Sarah, Eierhoff, Thorsten, Diedrich, Britta, Dengjel, Jörn, Nyström, Alexander, Imberty, Anne, Römer, Winfried

“…The opportunistic bacterium produces the fucose-specific lectin LecB, which has been identified as a virulence factor. LecB has a tetrameric structure with…”
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Bacterial lectin BambL acts as a B cell superantigen by Frensch, Marco, Jäger, Christina, Müller, Peter F., Tadić, Annamaria, Wilhelm, Isabel, Wehrum, Sarah, Diedrich, Britta, Fischer, Beate, Meléndez, Ana Valeria, Dengjel, Joern, Eibel, Hermann, Römer, Winfried

“…B cell superantigens crosslink conserved domains of B cell receptors (BCRs) and cause dysregulated, polyclonal B cell activation irrespective of normal…”
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Differential recognition of lipid domains by two Gb3-binding lectins by Schubert, Thomas, Sych, Taras, Madl, Josef, Xu, Maokai, Omidvar, Ramin, Patalag, Lukas J., Ries, Annika, Kettelhoit, Katharina, Brandel, Annette, Mely, Yves, Steinem, Claudia, Werz, Daniel B., Thuenauer, Roland, Römer, Winfried

“…The two lectins LecA from Pseudomonas aeruginosa and the B-subunit of Shiga toxin from Shigella dysenteriae (StxB) share the glycosphingolipid…”
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Stabilization of membrane topologies by proteinaceous remorin scaffolds by Su, Chao, Rodriguez-Franco, Marta, Lace, Beatrice, Nebel, Nils, Hernandez-Reyes, Casandra, Liang, Pengbo, Schulze, Eija, Mymrikov, Evgeny V., Gross, Nikolas M., Knerr, Julian, Wang, Hong, Siukstaite, Lina, Keller, Jean, Libourel, Cyril, Fischer, Alexandra A. M., Gabor, Katharina E., Mark, Eric, Popp, Claudia, Hunte, Carola, Weber, Wilfried, Wendler, Petra, Stanislas, Thomas, Delaux, Pierre-Marc, Einsle, Oliver, Grosse, Robert, Römer, Winfried, Ott, Thomas

“…In plants, the topological organization of membranes has mainly been attributed to the cell wall and the cytoskeleton. Additionally, few proteins, such as…”
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