Search Results - "Rožman, Kaja"

Synthesis and structure–activity relationship study of novel quinazolinone-based inhibitors of MurA by Hrast, Martina, Rožman, Kaja, Jukič, Marko, Patin, Delphine, Gobec, Stanislav, Sova, Matej

“…[Display omitted] •Synthesis and extensive SAR of a series of quinazolinone-based inhibitors of MurA.•Potent MurA inhibitors with IC50 in low micromolar range…”
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Discovery of Mycobacterium tuberculosis InhA Inhibitors by Binding Sites Comparison and Ligands Prediction by Štular, Tanja, Lešnik, Samo, Rožman, Kaja, Schink, Julia, Zdouc, Mitja, Ghysels, An, Liu, Feng, Aldrich, Courtney C, Haupt, V. Joachim, Salentin, Sebastian, Daminelli, Simone, Schroeder, Michael, Langer, Thierry, Gobec, Stanislav, Janežič, Dušanka, Konc, Janez

“…Drug discovery is usually focused on a single protein target; in this process, existing compounds that bind to related proteins are often ignored. We describe…”
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Cardiac ryanodine receptor N-terminal region biosensors identify novel inhibitors via FRET-based high-throughput screening by Zhang, Jingyan, Singh, Daniel P., Ko, Christopher Y., Nikolaienko, Roman, Wong King Yuen, Siobhan M., Schwarz, Jacob A., Treinen, Levy M., Tung, Ching-Chieh, Rožman, Kaja, Svensson, Bengt, Aldrich, Courtney C., Zima, Aleksey V., Thomas, David D., Bers, Donald M., Launikonis, Bradley S., Van Petegem, Filip, Cornea, Razvan L.

“…The N-terminal region (NTR) of ryanodine receptor (RyR) channels is critical for the regulation of Ca2+ release during excitation–contraction (EC) coupling in…”
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Evaluation of the published kinase inhibitor set to identify multiple inhibitors of bacterial ATP-dependent mur ligases by Hrast, Martina, Rožman, Kaja, Ogris, Iza, Škedelj, Veronika, Patin, Delphine, Sova, Matej, Barreteau, Hélène, Gobec, Stanislav, Grdadolnik, Simona Golič, Zega, Anamarija

“…The Mur ligases form a series of consecutive enzymes that participate in the intracellular steps of bacterial peptidoglycan biosynthesis. They therefore…”
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A new ‘golden age’ for the antitubercular target InhA by Rožman, Kaja, Sosič, Izidor, Fernandez, Raquel, Young, Robert J., Mendoza, Alfonso, Gobec, Stanislav, Encinas, Lourdes

“…•Recent advances in development of InhA inhibitors are presented.•We focus on inhibitors with a clear link to their in vivo activity.•Collected…”
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Recent Advances in the Development of Undecaprenyl Pyrophosphate Synthase Inhibitors as Potential Antibacterials by Jukic, Marko, Rozman, Kaja, Gobec, Stanislav

“…Expanding antibiotic use in clinical practice and emergence of bacterial resistance are fueling research efforts for the development of novel antibacterials…”
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Anthranilic Acid Inhibitors of Undecaprenyl Pyrophosphate Synthase (UppS), an Essential Enzyme for Bacterial Cell Wall Biosynthesis by Jukič, Marko, Rožman, Kaja, Sova, Matej, Barreteau, Hélène, Gobec, Stanislav

“…We report the successful implementation of virtual screening in the discovery of new inhibitors of undecaprenyl pyrophosphate synthase (UppS) from UppS is an…”
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Psoralen Derivatives as Inhibitors of Mycobacterium tuberculosis Proteasome by Rožman, Kaja, Alexander, Evan M, Ogorevc, Eva, Bozovičar, Krištof, Sosič, Izidor, Aldrich, Courtney C, Gobec, Stanislav

“…Protein degradation is a fundamental process in all living organisms. An important part of this system is a multisubunit, barrel-shaped protease complex called…”
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Discovery of new MurA inhibitors using induced-fit simulation and docking by Rožman, Kaja, Lešnik, Samo, Brus, Boris, Hrast, Martina, Sova, Matej, Patin, Delphine, Barreteau, Hélène, Konc, Janez, Janežič, Dušanka, Gobec, Stanislav

“…[Display omitted] We report on the successful application of ProBiS-CHARMMing web server in the discovery of new inhibitors of MurA, an enzyme that catalyzes…”
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Synthesis and Biological Evaluation of N-Aryl-N'-(5-(2-hydroxybenzoyl) pyrimidin-2-yl)guanidines as Toll-Like Receptor 4 Antagonists by Sova, Matej, Rozman, Kaja, Svajger, Urban, Rozman, Primoz, Gobec, Stanislav

“…Toll-like receptor 4 (TLR4) has been associated with several inflammatory diseases, such as sepsis, atherosclerosis and chronic pain. The aim of the present…”
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Docking study with biological validation on bacterial enzyme MurD by Zdouc, Mitja, Schink, Julia, Lešnik, Samo, Rožman, Kaja, Konc, Janez, Janežič, Dušanka, Gobec, Stanislav

“…Approved antibiotics currently target only a small number of bacterial enzymes, despite increasing rates of antibiotic-resistant microbes. New chemical…”
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High-Throughput Screening and Drug Development to Fix RyR Pathology by Rebbeck, Robyn T., Rozman, Kaja, Evans, Gabrielle M., Schwarz, Jacob, Baran, Marzena, Aldrich, Courtney C., Bers, Donald M., Thomas, David D., Cornea, Razvan L.

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High-Throughput Screening Yields Allosteric Inhibitors of Leaky RyRs for Therapeutic Development by Rebbeck, Robyn T., Evans, Gabrielle M., Rozman, Kaja, Schwarz, Jacob A., Wold, Michael C., Baran, Marzena, Aldrich, Courtney C., Bers, Donald M., Thomas, David D., Cornea, Razvan L.

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H Evaluation of the published kinase inhibitor set to identify multiple inhibitors of bacterial ATP-dependent mur ligases by Hrasta, Martina, Rozman, Kaja, Ogris, Iza, Skedelj, Veronika, Patin, Delphine, Sova, Matej, Barreteau, Helene, Gobec, Stanislav, Grdadolnik, Simona Golic, Zega, Anamarija

“…The Mur ligases form a series of consecutive enzymes that participate in the intracellular steps of bacterial peptidoglycan biosynthesis. They therefore…”
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Mycobacterial MenG: Partial Purification, Characterization, and Inhibition by Pujari, Venugopal, Rozman, Kaja, Dhiman, Rakesh K., Aldrich, Courtney C., Crick, Dean C.

“…Menaquinone (MK) is an essential component of the electron transport chain (ETC) in the gram-variable Mycobacterium tuberculosis and many Gram-positive…”
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