Search Results - "Rizzo, Carmelo"

Quantitation of Apurinic/Apyrimidinic Sites in Isolated DNA and in Mammalian Tissue with a Reduced Level of Artifacts by Chen, Haoqing, Yao, Lihua, Brown, Christina, Rizzo, Carmelo J, Turesky, Robert J

“…The apurinic/apyrimidinic (AP) site is a common lesion of DNA damage. The levels of AP sites reported in the literature cover a wide range, which is primarily…”
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Novel genomic island modifies DNA with 7-deazaguanine derivatives by Thiaville, Jennifer J., Kellner, Stefanie M., Yuan, Yifeng, Hutinet, Geoffrey, Thiaville, Patrick C., Jumpathong, Watthanachai, Mohapatra, Susovan, Brochier-Armanet, Celine, Letarov, Andrey V., Hillebrand, Roman, Malik, Chanchal K., Rizzo, Carmelo J., Dedon, Peter C., de Crécy-Lagard, Valérie

“…The discovery of ∼20-kb gene clusters containing a family of paralogs of tRNA guanosine transglycosylase genes, called tgtA5, alongside 7-cyano-7-deazaguanine…”
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Mass Spectrometry-Based Method to Measure Aflatoxin B1 DNA Adducts in Formalin-Fixed Paraffin-Embedded Tissues by Bellamri, Medjda, Yao, Lihua, Tomar, Rachana, Vartanian, Vladimir, Rizzo, Carmelo J., Stone, Michael P., Groopman, John D., Lloyd, R. Stephen, Turesky, Robert J.

“…Aflatoxin B1 (AFB1) is a potent human liver carcinogen produced by certain molds, particularly Aspergillus flavus and Aspergillus parasiticus, which…”
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Anthracyclines React with Apurinic/Apyrimidinic Sites in DNA by Bellamri, Medjda, Terrell, John T., Brandt, Kyle, Gruppi, Francesca, Turesky, Robert J., Rizzo, Carmelo J.

“…The combination of doxorubicin (Adriamycin) and cyclophosphamide, referred to as AC chemotherapy, is commonly used for the clinical treatment of breast and…”
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Mass Spectrometry-Based Method to Measure Aflatoxin B 1 DNA Adducts in Formalin-Fixed Paraffin-Embedded Tissues by Bellamri, Medjda, Yao, Lihua, Tomar, Rachana, Vartanian, Vladimir, Rizzo, Carmelo J, Stone, Michael P, Groopman, John D, Lloyd, R Stephen, Turesky, Robert J

“…Aflatoxin B (AFB ) is a potent human liver carcinogen produced by certain molds, particularly and , which contaminate peanuts, corn, rice, cottonseed, and…”
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Enzymatic bypass and the structural basis of miscoding opposite the DNA adduct 1,N2-ethenodeoxyguanosine by human DNA translesion polymerase η by Ghodke, Pratibha P., Mali, Jyotirling R., Patra, Amritraj, Rizzo, Carmelo J., Guengerich, F. Peter, Egli, Martin

“…Etheno (ε)-adducts, e.g., 1,N2-ε−guanine (1,N2-ε-G) and 1,N6-ε−adenine (1,N6-ε-A), are formed through the reaction of DNA with metabolites of vinyl compounds…”
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mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo by Liu, Minmin, Bandaru, Viswanath, Bond, Jeffrey P, Jaruga, Pawel, Zhao, Xiaobei, Christov, Plamen P, Burrows, Cynthia J, Rizzo, Carmelo J, Dizdaroglu, Miral, Wallace, Susan S

“…To protect cells from oxidative DNA damage and mutagenesis, organisms possess multiple glycosylases to recognize the damaged bases and to initiate the Base…”
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Kinetics of DNA Adducts and Abasic Site Formation in Tissues of Mice Treated with a Nitrogen Mustard by Chen, Haoqing, Cui, Ziyou, Hejazi, Leila, Yao, Lihua, Walmsley, Scott J, Rizzo, Carmelo J, Turesky, Robert J

“…Nitrogen mustards (NM) are an important class of chemotherapeutic drugs used in the treatment of malignant tumors. The accepted mechanism of action of NM is…”
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Chemistry and biology of DNA containing 1,N(2)-deoxyguanosine adducts of the alpha,beta-unsaturated aldehydes acrolein, crotonaldehyde, and 4-hydroxynonenal by Minko, Irina G, Kozekov, Ivan D, Harris, Thomas M, Rizzo, Carmelo J, Lloyd, R Stephen, Stone, Michael P

“…The alpha,beta-unsaturated aldehydes (enals) acrolein, crotonaldehyde, and trans-4-hydroxynonenal (4-HNE) are products of endogenous lipid peroxidation,…”
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Mutagenic potential of nitrogen mustard-induced formamidopyrimidine DNA adduct: Contribution of the non-canonical α-anomer by Minko, Irina G., Rizzo, Carmelo J., Lloyd, R. Stephen

“…Nitrogen mustards (NMs) are DNA-alkylating compounds that represent the earliest anticancer drugs. However, clinical use of NMs is limited because of their own…”
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Chemistry and Biology of DNA Containing 1,N 2-Deoxyguanosine Adducts of the α,β-Unsaturated Aldehydes Acrolein, Crotonaldehyde, and 4-Hydroxynonenal by Minko, Irina G, Kozekov, Ivan D, Harris, Thomas M, Rizzo, Carmelo J, Lloyd, R. Stephen, Stone, Michael P

“…The α,β-unsaturated aldehydes (enals) acrolein, crotonaldehyde, and trans-4-hydroxynonenal (4-HNE) are products of endogenous lipid peroxidation, arising as a…”
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Site-Specific Synthesis of Oligonucleotides Containing 6‑Oxo‑M1dG, the Genomic Metabolite of M1dG, and Liquid Chromatography–Tandem Mass Spectrometry Analysis of Its In Vitro Bypass by Human Polymerase ι by Christov, Plamen P, Richie-Jannetta, Robyn, Kingsley, Philip J, Vemulapalli, Anoop, Kim, Kwangho, Sulikowski, Gary A, Rizzo, Carmelo J, Ketkar, Amit, Eoff, Robert L, Rouzer, Carol A, Marnett, Lawrence J

“…The lipid peroxidation product malondialdehyde and the DNA peroxidation product base-propenal react with dG to generate the exocyclic adduct, M1dG. This…”
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Characterization of Nitrogen Mustard Formamidopyrimidine Adduct Formation of Bis(2-chloroethyl)ethylamine with Calf Thymus DNA and a Human Mammary Cancer Cell Line by Gruppi, Francesca, Hejazi, Leila, Christov, Plamen P, Krishnamachari, Sesha, Turesky, Robert J, Rizzo, Carmelo J

“…A robust, quantitative ultraperformance liquid chromatography ion trap multistage scanning mass spectrometric (UPLC/MS3) method was established to characterize…”
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Site-Specific Synthesis of Oligonucleotides Containing 6-Oxo-M 1 dG, the Genomic Metabolite of M 1 dG, and Liquid Chromatography-Tandem Mass Spectrometry Analysis of Its In Vitro Bypass by Human Polymerase ι by Christov, Plamen P, Richie-Jannetta, Robyn, Kingsley, Philip J, Vemulapalli, Anoop, Kim, Kwangho, Sulikowski, Gary A, Rizzo, Carmelo J, Ketkar, Amit, Eoff, Robert L, Rouzer, Carol A, Marnett, Lawrence J

“…The lipid peroxidation product malondialdehyde and the DNA peroxidation product base-propenal react with dG to generate the exocyclic adduct, M dG. This…”
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Checkpoint Signaling from a Single DNA Interstrand Crosslink by Ben-Yehoyada, Merav, Wang, Lily C., Kozekov, Ivan D., Rizzo, Carmelo J., Gottesman, Max E., Gautier, Jean

“…DNA interstrand crosslinks (ICLs) are the most toxic lesions induced by chemotherapeutic agents such as mitomycin C and cisplatin. By covalently linking both…”
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Translesion Synthesis of the N(2)-2'-Deoxyguanosine Adduct of the Dietary Mutagen IQ in Human Cells: Error-Free Replication by DNA Polymerase κ and Mutagenic Bypass by DNA Polymerases η, ζ, and Rev1 by Bose, Arindam, Millsap, Amy D, DeLeon, Arnie, Rizzo, Carmelo J, Basu, Ashis K

“…Translesion synthesis (TLS) of the N(2)-2'-deoxyguanosine (dG-N(2)-IQ) adduct of the carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) was investigated…”
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Translesion Synthesis of the N 2‑2′-Deoxyguanosine Adduct of the Dietary Mutagen IQ in Human Cells: Error-Free Replication by DNA Polymerase κ and Mutagenic Bypass by DNA Polymerases η, ζ, and Rev1 by Bose, Arindam, Millsap, Amy D, DeLeon, Arnie, Rizzo, Carmelo J, Basu, Ashis K

“…Translesion synthesis (TLS) of the N 2-2′-deoxyguanosine (dG-N 2-IQ) adduct of the carcinogen 2-amino-3-methylimidazo­[4,5-f]­quinoline (IQ) was investigated…”
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Interstrand DNA Cross-Links Induced by α,β-Unsaturated Aldehydes Derived from Lipid Peroxidation and Environmental Sources by Stone, Michael P, Cho, Young-Jin, Huang, Hai, Kim, Hye-Young, Kozekov, Ivan D, Kozekova, Albena, Wang, Hao, Minko, Irina G, Lloyd, R. Stephen, Harris, Thomas M, Rizzo, Carmelo J

“…Significant levels of the 1,N 2-γ-hydroxypropano-dG adducts of the α,β-unsaturated aldehydes acrolein, crotonaldehyde, and 4-hydroxy-2E-nonenal (HNE) have been…”
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Xeroderma pigmentosum complementation group C protein (XPC) serves as a general sensor of damaged DNA by Shell, Steven M., Hawkins, Edward K., Tsai, Miaw-Sheue, Hlaing, Aye Su, Rizzo, Carmelo J., Chazin, Walter J.

“…•High-throughput fluorescence anisotropy assay used to measure affinity of human XPC for damaged DNA.•Binding affinity tested for eight DNA lesions contained…”
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Synthesis and Characterization of Oligonucleotides Containing a Nitrogen Mustard Formamidopyrimidine Monoadduct of Deoxyguanosine by Christov, Plamen P, Son, Kyu-Jun, Rizzo, Carmelo J

“…N 5-Substituted formamidopyrimidine adducts have been observed from the reaction of dGuo or DNA with aziridine containing electrophiles, including nitrogen…”
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