Search Results - "Rizk, Shahir S"

A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria by Mbengue, Alassane, Bhattacharjee, Souvik, Pandharkar, Trupti, Liu, Haining, Estiu, Guillermina, Stahelin, Robert V., Rizk, Shahir S., Njimoh, Dieudonne L., Ryan, Yana, Chotivanich, Kesinee, Nguon, Chea, Ghorbal, Mehdi, Lopez-Rubio, Jose-Juan, Pfrender, Michael, Emrich, Scott, Mohandas, Narla, Dondorp, Arjen M., Wiest, Olaf, Haldar, Kasturi

“…Artemisinins are key anti-malarial drugs, but artemisinin resistance has been increasing; this study identifies the molecular target of artemisinins as…”
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Generating conformation-specific synthetic antibodies to trap proteins in selected functional states by Paduch, Marcin, Koide, Akiko, Uysal, Serdar, Rizk, Shahir S., Koide, Shohei, Kossiakoff, Anthony A.

“…[Display omitted] ► We present a streamlined method of generating synthetic antibodies by phage display. ► In vitro selections allow for unique control over…”
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Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins by Kossiakoff, Anthony A, Rizk, Shahir S, Paduch, Marcin, Heithaus, John H, Duguid, Erica M, Sandstrom, Andrew

“…Allosteric effectors have the ability to modulate protein-ligand interactions in a controlled fashion. Now a novel class of antibody-like affinity reagents,…”
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Targeted rescue of cancer-associated IDH1 mutant activity using an engineered synthetic antibody by Rizk, Shahir S., Mukherjee, Somnath, Koide, Akiko, Koide, Shohei, Kossiakoff, Anthony A.

“…We have utilized a high-diversity phage display library to engineer antibody fragments (Fabs) that can modulate the activity of the enzyme isocitrate…”
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Construction of a fluorescent biosensor family by De Lorimier, Robert M., Smith, J. Jeff, Dwyer, Mary A., Looger, Loren L., Sali, Kevin M., Paavola, Chad D., Rizk, Shahir S., Sadigov, Shamil, Conrad, David W., Loew, Leslie, Hellinga, Homme W.

“…Bacterial periplasmic binding proteins (bPBPs) are specific for a wide variety of small molecule ligands. bPBPs undergo a large, ligand‐mediated conformational…”
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engineered substance P variant for receptor-mediated delivery of synthetic antibodies into tumor cells by Rizk, Shahir S, Luchniak, Anna, Uysal, Serdar, Brawley, Crista M, Rock, Ronald S, Kossiakoff, Anthony A

“…We have developed and tested a robust delivery method for the transport of proteins to the cytoplasm of mammalian cells without compromising the integrity of…”
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Identification of cognate ligands for the Escherichia coli phnD protein product and engineering of a reagentless fluorescent biosensor for phosphonates by Rizk, Shahir S., Cuneo, Matthew J., Hellinga, Homme W.

“…The Escherichia coli phnD gene is hypothesized to code for the periplasmic binding component of a phosphonate uptake system. Here we report the…”
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Computational Design of Receptors for an Organophosphate Surrogate of the Nerve Agent Soman by Allert, Malin, Rizk, Shahir S., Looger, Loren L., Hellinga, Homme W., Wells, James A.

“…We report the computational design of soluble protein receptors for pinacolyl methyl phosphonic acid (PMPA), the predominant hydrolytic product of the nerve…”
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Engineered synthetic antibodies as probes to quantify the energetic contributions of ligand binding to conformational changes in proteins by Mukherjee, Somnath, Griffin, Dionne H., Horn, James R., Rizk, Shahir S., Nocula-Lugowska, Malgorzata, Malmqvist, Magnus, Kim, Sangwoo S., Kossiakoff, Anthony A.

“…Conformational changes in proteins due to ligand binding are ubiquitous in biological processes and are integral to many biological systems. However, it is…”
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Engineering a fluorescence biosensor for the herbicide glyphosate by N’Guetta, Pierre-Emmanuel Y, Fink, Maggie M, Rizk, Shahir S

“…Abstract Glyphosate, the active ingredient in RoundUp, is the most widely used herbicide on the globe, and has recently been linked to an increased risk in…”
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Substance P Derivatives as Versatile Tools for Specific Delivery of Various Types of Biomolecular Cargo by Rizk, Shahir S, Misiura, Agnieszka, Paduch, Marcin, Kossiakoff, Anthony A

“…The use of proteins or nucleic acids as therapeutic agents has been severely hampered by their intrinsic inability to cross the cell membrane. Moreover, common…”
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Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling by Rizk, Shahir S, Kouadio, Jean-Louis K, Szymborska, Anna, Duguid, Erica M, Mukherjee, Somnath, Zheng, Jiamao, Clevenger, Charles V, Kossiakoff, Anthony A

“…Many receptors function by binding to multiple ligands, each eliciting a distinct biological output. The extracellular domain of the human prolactin receptor…”
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Control of a biomolecular motor-powered nanodevice with an engineered chemical switch by Montemagno, Carlo D, Liu, Haiqing, Schmidt, Jacob J, Bachand, George D, Rizk, Shahir S, Looger, Loren L, Hellinga, Homme W

“…The biophysical and biochemical properties of motor proteins have been well-studied, but these motors also show promise as mechanical components in hybrid…”
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Molecular Modeling and Simulations of the Transmembrane Domain of Human Growth Hormone Receptor by Kumar, Ritesh, Rizk, Shahir S., Kossiakoff, Anthony A., Im, Wonpil

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