Leptin gene Polymorphism and Leptin protein levels in Pediatric Autoimmune Hepatitis

Leptin gene Polymorphism and Leptin protein levels in Pediatric Autoimmune Hepatitis

Leptin plays a role in regulating energy balance, immunity, and inflammation. Studies suggest higher leptin levels might be associated with various autoimmune diseases. Most of them were in adult. To our knowledge, our study is one of the few that describe serum leptin level and leptin gene polymorp...

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Bibliographic Details
Published in:Journal of immunoassay & immunochemistry Vol. 45; no. 3; pp. 210 - 232
Main Authors: Awad, Samah M., Elgazzar, Hanaa M., Hassan, Eman H., Allam, Esraa T., Zaid, Ahmed B., Elkhadry, Sally W., Rizk, Sara K., Fotoh, Dina S, Salem, Tahany Abd El Hamid
Format: Journal Article
Language:English
Published: England Taylor & Francis 03-05-2024
Marcel Dekker, Inc
Subjects:
Adolescent
Autoimmune diseases
autoimmune hepatitis
Child
Child, Preschool
Children
Energy balance
Enzyme-linked immunosorbent assay
Female
Gene polymorphism
Genetic diversity
Genotype
Genotyping
Hepatitis
Hepatitis, Autoimmune - blood
Hepatitis, Autoimmune - genetics
Humans
Leptin
Leptin - blood
Leptin - genetics
Leptin gene polymorphism
Male
Patients
Pediatrics
Polymorphism
Polymorphism, Genetic
Therapeutic targets
Leptin gene polymorphism
autoimmune hepatitis
children
Leptin
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Summary:Leptin plays a role in regulating energy balance, immunity, and inflammation. Studies suggest higher leptin levels might be associated with various autoimmune diseases. Most of them were in adult. To our knowledge, our study is one of the few that describe serum leptin level and leptin gene polymorphism in children with autoimmune hepatitis (AIH). Our study aims to explore the association between serum leptin level and genetic variations in leptin gene with the likelihood of AIH in children. Thirty-one children with AIH and 29 healthy children serving as a control group were included. Serum leptin levels were measured by ELISA assays. Leptin rs2167270 genotyping was done using the real time-PCR. The relationship of serum leptin level and leptin gene polymorphism with patients' data was studied. Patients follow up to assess treatment response. Children with AIH had significantly higher levels of leptin compared to healthy controls. GG genotype was significantly more prevalent in the AIH group compared to controls. High serum leptin levels and leptin gene polymorphism may play a role in AIH development. It is worthy to recognize if leptin can serve as diagnostic and/or therapeutic target in AIH in children.
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ISSN:1532-1819
1532-4230
1532-4230
DOI:10.1080/15321819.2024.2360083