Capnocytophaga sputigena bloodstream infection in hematopoietic stem cell transplantations: two cases report and review of the literature

Capnocytophaga sputigena bloodstream infection in hematopoietic stem cell transplantations: two cases report and review of the literature

Capnocytophaga is a group of facultative anaerobic gram-negative bacteria present in the oral cavity of humans, dogs and cats, as part of their normal oral flora. Here, we described two cases of bloodstream infections (BSI) caused by Capnocytophaga in neutropenic autologous hematopoietic stem cell t...

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Published in:Revista do Instituto de Medicina Tropical de São Paulo Vol. 62; pp. 1 - 4
Main Authors: Mendes, Fernanda Rodrigues, Bruniera, Felipe Ribeiro, Schmidt, Jayir, Cury, Ana Paula, Rizeck, Camila, Higashino, Hermes, Oliveira, Fernando Nivaldo, Rossi, Flavia, Rocha, Vanderson, Costa, Silvia Figueiredo
Format: Journal Article
Language:English
Published: São Paulo Instituto de Medicina Tropical de Sao Paulo 01-01-2020
Instituto de Medicina Tropical
Instituto de Medicina Tropical de São Paulo
Universidade de São Paulo (USP)
Subjects:
Bacteria
Bloodstream infection
Bone marrow
Capnocytophaga
Case Report
Catheters
Chemotherapy
Fever
Gram-negative bacteria
Hematopoietic stem cell transplantation
Infections
Laboratories
Lasers
Microbiota
Mucositis
Neutropenia
Neutrophils
Patients
Stem cell transplantation
Stem cells
TROPICAL MEDICINE
Bloodstream infection
Capnocytophaga
Hematopoietic stem cell transplantation
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Summary:Capnocytophaga is a group of facultative anaerobic gram-negative bacteria present in the oral cavity of humans, dogs and cats, as part of their normal oral flora. Here, we described two cases of bloodstream infections (BSI) caused by Capnocytophaga in neutropenic autologous hematopoietic stem cell transplantation (auto-HSCT) patients with mucositis (Grade I and Grade III) identified by Maldi-Tof. They were successfully treated with β-lactam (meropenem and piperacillin-tazobactam). The species C. sputigena was confirmed by 16S rRNA gene sequencing in one patient. The review of literature showed that C. ochraceae was the most frequent species causing BSI in auto-HSCT patients and that the patients usually presented mucositis and were neutropenic at the onset of the infection.
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On behalf of all authors, the corresponding author states that there is no conflict of interest.
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ISSN:1678-9946
0036-4665
1678-9946
DOI:10.1590/s1678-9946202062048