Search Results - "Riviere, Gilles"

Imatinib pharmacokinetics and its correlation with response and safety in chronic-phase chronic myeloid leukemia: a subanalysis of the IRIS study by Larson, Richard A., Druker, Brian J., Guilhot, Francois, O'Brien, Stephen G., Riviere, Gilles J., Krahnke, Tillmann, Gathmann, Insa, Wang, Yanfeng

“…Imatinib at 400 mg daily is standard treatment for chronic myeloid leukemia in chronic phase. We here describe the correlation of imatinib trough plasma…”
Get full text

A walk in the PARC: developing and implementing 21st century chemical risk assessment in Europe by Marx-Stoelting, P., Rivière, G., Luijten, M., Aiello-Holden, K., Bandow, N., Baken, K., Cañas, A., Castano, A., Denys, S., Fillol, C., Herzler, M., Iavicoli, I., Karakitsios, S., Klanova, J., Kolossa-Gehring, M., Koutsodimou, A., Vicente, J. Lobo, Lynch, I., Namorado, S., Norager, S., Pittman, A., Rotter, S., Sarigiannis, D., Silva, M. J., Theunis, J., Tralau, T., Uhl, M., van Klaveren, J., Wendt-Rasch, L., Westerholm, E., Rousselle, C., Sanders, P.

“…Current approaches for the assessment of environmental and human health risks due to exposure to chemical substances have served their purpose reasonably well…”
Get full text

Absorption, Distribution, Metabolism, and Elimination of the Direct Renin Inhibitor Aliskiren in Healthy Volunteers by WALDMEIER, Felix, GLAENZEL, Ulrike, WIRZ, Bernard, OBERER, Lukas, SCHMID, Dietmar, SEIBERLING, Michael, VALENCIA, Jessica, RIVIERE, Gilles-Jacques, END, Peter, VAIDYANATHAN, Sujata

“…Aliskiren (2( S ),4( S ),5( S ),7( S )- N -(2-carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxypropoxy)phenyl]-octanamid…”
Get full text

Imatinib does not induce cardiotoxicity at clinically relevant concentrations in preclinical studies by Wolf, Armin, Couttet, Philippe, Dong, Min, Grenet, Olivier, Heron, Marcia, Junker, Ursula, Laengle, Ulrich, Ledieu, David, Marrer, Estelle, Nussher, Anja, Persohn, Elke, Pognan, Francois, Rivière, Gilles-Jacques, Roth, Daniel Robert, Trendelenburg, Christian, Tsao, Jeffrey, Roman, Danielle

“…Abstract Cytotoxic concentrations of imatinib mesylate (10–50 μM) were required to trigger markers of apoptosis and endoplasmic reticulum stress response in…”
Get full text

The effect of age, gender, and body mass index on the pharmacokinetics and pharmacodynamics of vildagliptin in healthy volunteers by He, Yan‐Ling, Sabo, Ron, Campestrini, Joelle, Wang, Yibin, Riviere, Gilles‐Jacques, Nielsen, Jace C., Rosenberg, Mitchell, Ligueros‐Saylan, Monica, Howard, Dan, Dole, William P.

“…What is already known about this subject • Vildagliptin is a new, potent, and selective inhibitor of DPP‐4. • The efficacy and safety of vildagliptin in type 2…”
Get full text

Multiple-Dose FTY720: Tolerability, Pharmacokinetics, and Lymphocyte Responses in Healthy Subjects by Kovarik, John M., Schmouder, Robert, Barilla, Denise, Riviere, Gilles-Jacques, Wang, Yibin, Hunt, Thomas

“…FTY720 is a sphingosine‐1‐phosphate receptor agonist being developed as an immunomodulator for acute rejection prophylaxis after organ transplantation. This…”
Get full text

Effect of Food, Type of Food, and Time of Food Intake on Deferasirox Bioavailability: Recommendations for an Optimal Deferasirox Administration Regimen by Galanello, Renzo, Piga, Antonio, Cappellini, Maria Domenica, Forni, Gian Luca, Zappu, Antonella, Origa, Raffaella, Dutreix, Catherine, Belleli, Rossella, Ford, John M., Rivière, Gilles-Jacques, Balez, Sébastien, Alberti, Daniele, Séchaud, Romain

“…Deferasirox (ICL670) is representative of a new class of tridentate iron chelators, formulated as tablets for dispersion. Deferasirox has exhibited high…”
Get full text

Nanomaterials in Food – Prioritisation & Assessment by Anastasi, Eleni, Riviere, Gilles, Teste, Bruno

“…Nanomaterials (NMs) are of significant economic interest and have a huge impact on many industries including the food industry. The main application in food…”
Get full text

Effects of imatinib (Glivec) on the pharmacokinetics of metoprolol, a CYP2D6 substrate, in Chinese patients with chronic myelogenous leukaemia by Wang, Yanfeng, Zhou, Li, Dutreix, Catherine, Leroy, Elisabeth, Yin, Qi, Sethuraman, Venkat, Riviere, Gilles‐Jacques, Yin, Ophelia Q. P., Schran, Horst, Shen, Zhi‐Xiang

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Imatinib, a tyrosine kinase inhibitor, exhibits a competitive inhibition on the CYP450 2D6 isozyme with a Ki value…”
Get full text

Ketoconazole Increases Fingolimod Blood Levels in a Drug Interaction via CYP4F2 Inhibition by Kovarik, John M., Dole, Kiran, Riviere, Gilles-Jacques, Pommier, Francoise, Maton, Steve, Jin, Yi, Lasseter, Kenneth C., Schmouder, Robert L.

“…The sphingosine‐1‐phosphate receptor modulator fingolimod is predominantly hydroxylated by cytochrome CYP4F2. In vitro experiments showed that ketoconazole…”
Get full text

The ability of atropine to prevent and reverse the negative chronotropic effect of fingolimod in healthy subjects by Kovarik, John M., Slade, Alan, Riviere, Gilles‐Jacques, Neddermann, Daniel, Maton, Steve, Hunt, Thomas L., Schmouder, Robert L.

“…WHAT IS KNOWN ABOUT THIS SUBJECT • Clinical pharmacology and clinical therapeutic studies of fingolimod demonstrate that heart rate after the initial dose…”
Get full text

Pharmacokinetics and pharmacodynamics of vildagliptin in patients with type 2 diabetes mellitus by HE, Yan-Ling, SERRA, Denise, YIBIN WANG, CAMPESTRINI, Joelle, RIVIERE, Gilles-Jacques, DEACON, Carolyn F, HOLST, Jens J, SCHWARTZ, Sherwyn, NIELSEN, Jace C, LIGUEROS-SAYLAN, Monica

“…Vildagliptin is a dipeptidyl peptidase IV (DPP-4) inhibitor currently under development for the treatment of type 2 diabetes mellitus. To assess the…”
Get full text

Microplastics in seafood: Benchmark protocol for their extraction and characterization by Dehaut, Alexandre, Cassone, Anne-Laure, Frère, Laura, Hermabessiere, Ludovic, Himber, Charlotte, Rinnert, Emmanuel, Rivière, Gilles, Lambert, Christophe, Soudant, Philippe, Huvet, Arnaud, Duflos, Guillaume, Paul-Pont, Ika

“…Pollution of the oceans by microplastics (<5 mm) represents a major environmental problem. To date, a limited number of studies have investigated the level of…”
Get full text

Microplastic contamination and pollutant levels in mussels and cockles collected along the channel coasts by Hermabessiere, Ludovic, Paul-Pont, Ika, Cassone, Anne-Laure, Himber, Charlotte, Receveur, Justine, Jezequel, Ronan, El Rakwe, Maria, Rinnert, Emmanuel, Rivière, Gilles, Lambert, Christophe, Huvet, Arnaud, Dehaut, Alexandre, Duflos, Guillaume, Soudant, Philippe

“…Nowadays, environmental pollution by microplastics (<5 mm; MP) is a major issue. MP are contaminating marine organisms consumed by humans. This work studied MP…”
Get full text

Evaluation of Pharmacokinetic Interactions Between Vildagliptin and Digoxin in Healthy Volunteers by He, Yan-Ling, Sabo, Ron, Sunkara, Gangadhar, Bizot, Marie-Noëlle, Riviere, Gilles-Jacques, Leon, Selene, Ligueros-Saylan, Monica, Dole, William P., Howard, Dan

“…Vildagliptin is a novel antidiabetic agent that is an orally active, potent, and selective inhibitor of dipeptidyl peptidase IV, the enzyme responsible for…”
Get full text

Evaluation of the safety and efficacy of lactic acid to reduce microbiological surface contamination on carcases from kangaroos, wild pigs, goats and sheep by Lambré, Claude, Barat Baviera, José Manuel, Bolognesi, Claudia, Chesson, Andrew, Cocconcelli, Pier Sandro, Crebelli, Riccardo, Gott, David Michael, Grob, Konrad, Lampi, Eugenia, Riviere, Gilles, Steffensen, Inger‐Lise, Tlustos, Christina, Van Loveren, Henk, Vernis, Laurence, Zorn, Holger, Bolton, Declan, Bover‐Cid, Sara, de Knecht, Joop, Peixe, Luisa, Skandamis, Panagotis, Martino, Carla, Messens, Winy, Tard, Alexandra, Mortensen, Alicja

“…Studies evaluating the safety and efficacy of lactic acid to reduce microbiological surface contamination from carcases of wild game (i.e. kangaroos and wild…”
Get full text

Oral-intravenous crossover study of fingolimod pharmacokinetics, lymphocyte responses and cardiac effects by Kovarik, John M., Hartmann, Stefan, Bartlett, Michael, Riviere, Gilles-Jacques, Neddermann, Daniel, Wang, Yibin, Port, Andreas, Schmouder, Robert L.

“…Objective. The pharmacokinetics and lymphocyte responses to the immunomodulator fingolimod (FTY720) were characterized after oral and intravenous…”
Get full text

Dietary exposure to pesticide residues and associated health risks in infants and young children – Results of the French infant total diet study by Nougadère, Alexandre, Sirot, Véronique, Cravedi, Jean-Pierre, Vasseur, Paule, Feidt, Cyril, Fussell, Richard J., Hu, Renwei, Leblanc, Jean-Charles, Jean, Julien, Rivière, Gilles, Sarda, Xavier, Merlo, Mathilde, Hulin, Marion

“…•First infant TDS on pesticide residues.•78 pesticides detected at levels below the maximum residue levels.•67% of the baby food samples with detected…”
Get full text

Impact of sociodemographic profile, generation and bioaccumulation on lifetime dietary and internal exposures to PCBs by Pruvost-Couvreur, Manon, Béchaux, Camille, Rivière, Gilles, Le Bizec, Bruno

“…Polychlorinated biphenyls (PCBs) are persistent organic pollutants triggering numerous adverse effects. Because they are present in various food, dietary…”
Get full text

Effect of the novel oral dipeptidyl peptidase IV inhibitor vildagliptin on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects by He, Yan-Ling, Sabo, Ron, Riviere, Gilles-Jacques, Sunkara, Gangadhar, Leon, Selene, Ligueros-Saylan, Monica, Rosenberg, Mitchell, Dole, William P., Howard, Dan

“…ABSTRACT Objective: Vildagliptin is a potent and selective dipeptidyl peptidase‑IV (DPP‑4) inhibitor that improves glycemic control in patients with type 2…”
Get full text