Ventricular hypertrophy increases NT-proBNP in subjects with and without hypertension

Background: It has been published that hypertension (HT) must be taken into account when using NT-proBNP, but left ventricular (LV) hypertrophy without HT could be a cause of NT-proBNP elevation. In a population study we compared NT-proBNP in subjects with hypertrophy, with and without diagnosis of...

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Published in:	International journal of cardiology Vol. 96; no. 2; pp. 265 - 271
Main Authors:	Rivera Otero, J.Miguel, Taléns-Visconti, Raquel, Salvador, Antonio, Bertomeu, Vicente, Miró, Vicente, Jordán, Alejandro, Sogorb, Francisco, Cortés, Raquel, Payá, Rafael, Diago, Jose Luis, Grau, Guillermo
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier Ireland Ltd 01-08-2004 Elsevier Science
Subjects:	Aged Arterial hypertension. Arterial hypotension Biological and medical sciences Biomarkers - blood Blood and lymphatic vessels Cardiology. Vascular system Case-Control Studies Clinical manifestations. Epidemiology. Investigative techniques. Etiology Cross-Sectional Studies Echocardiography, Doppler Female Humans Hypertension Hypertension - blood Hypertension - diagnosis Hypertension - epidemiology Hypertrophy, Left Ventricular - blood Hypertrophy, Left Ventricular - diagnostic imaging Hypertrophy, Left Ventricular - epidemiology Left ventricular hypertrophy Male Medical sciences Middle Aged Natriuretic Peptide, Brain Nerve Tissue Proteins - blood NT-proBNP Observer Variation Peptide Fragments - blood Probability Prognosis Reference Values Reproducibility of Results Risk Assessment Severity of Illness Index Statistics, Nonparametric Hypertension NT-proBNP Left ventricular hypertrophy Human Cardiovascular disease Increase Left ventricle Hypertrophy
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Summary:	Background: It has been published that hypertension (HT) must be taken into account when using NT-proBNP, but left ventricular (LV) hypertrophy without HT could be a cause of NT-proBNP elevation. In a population study we compared NT-proBNP in subjects with hypertrophy, with and without diagnosis of HT. Methods: We studied 215 subjects from a random sample of 432 people who had declared to suffer from dyspnea. These 432 subjects were referred to their hospital where blood samples were taken, an echo-Doppler study was performed and a specific questionnaire was completed. We got a positive answer from 215, and 52 (24%) have LV hypertrophy. Results: When we compared NT-proBNP in non-hypertrophic population, 148±286 pg/ml, with NT-proBNP in LV hypertrophic population, 202±209 pg/ml, we found P<0.001. In the hypertrophic group, when we compared NT-proBNP (199±201 pg/ml) in normotensive subjects (LV mass index 170±70 g/m 2, Vp 50±18 cm/s, LVEF 62±8) with NT-proBNP (205±220 pg/ml) in subjects with diagnosis of HT (LV mass index 169±37 g/m 2, Vp 55±20 cm/s, LVEF 64±10), we found NS. Conclusions: This population study shows that NT-proBNP is elevated in patients with LV hypertrophy with or without HT. In LV hypertrophy the presence of HT does not influence the peptide levels significantly.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0167-5273 1874-1754
DOI:	10.1016/j.ijcard.2003.07.019