Search Results - "Rivera, Brian K"

Hypoxia induces chemoresistance in ovarian cancer cells by activation of signal transducer and activator of transcription 3 by Selvendiran, Karuppaiyah, Bratasz, Anna, Kuppusamy, M. Lakshmi, Tazi, Mia F., Rivera, Brian K., Kuppusamy, Periannan

“…Signal transducer and activator of transcription 3 (STAT3) is activated in a variety of human cancers, including ovarian cancer. The molecular mechanism by…”
Get full text

HO-3867, a Safe STAT3 Inhibitor, Is Selectively Cytotoxic to Ovarian Cancer by RATH, Kellie S, NAIDU, Shan K, HOUGHTON, Peter, HIDEG, Kálmán, KUPPUSAMY, Periannan, COHN, David E, SELVENDIRAN, Karuppaiyah, LATA, Pushpa, BID, Hemant K, RIVERA, Brian K, MCCANN, Georgia A, TIERNEY, Brent J, ELNAGGAR, Adam C, BRAVO, Veronica, LEONE, Gustavo

“…STAT3 is well corroborated preclinically as a cancer therapeutic target, but tractable translational strategies for its blockade by small molecule inhibitors…”
Get full text

Pharmacological preconditioning of mesenchymal stem cells with trimetazidine (1-[2,3,4-trimethoxybenzyl]piperazine) protects hypoxic cells against oxidative stress and enhances recovery of myocardial function in infarcted heart through Bcl-2 expression by Wisel, Sheik, Khan, Mahmood, Kuppusamy, M Lakshmi, Mohan, I Krishna, Chacko, Simi M, Rivera, Brian K, Sun, Benjamin C, Hideg, Kálmán, Kuppusamy, Periannan

“…Stem cell transplantation is a possible therapeutic option to repair ischemic damage to the heart. However, it is faced with a number of challenges including…”
Get more information

Early prediction of spontaneous Patent Ductus Arteriosus (PDA) closure and PDA-associated outcomes: a prospective cohort investigation by Slaughter, Jonathan L, Cua, Clifford L, Notestine, Jennifer L, Rivera, Brian K, Marzec, Laura, Hade, Erinn M, Maitre, Nathalie L, Klebanoff, Mark A, Ilgenfritz, Megan, Le, Vi T, Lewandowski, Dennis J, Backes, Carl H

“…Patent ductus arteriosus (PDA), the most commonly diagnosed cardiovascular condition in preterm infants, is associated with increased mortality and harmful…”
Get full text

Safe and targeted anticancer efficacy of a novel class of antioxidant-conjugated difluorodiarylidenyl piperidones: Differential cytotoxicity in healthy and cancer cells by Selvendiran, Karuppaiyah, Ahmed, Shabnam, Dayton, Alex, Kuppusamy, M. Lakshmi, Tazi, Mia, Bratasz, Anna, Tong, Liyue, Rivera, Brian K., Kálai, Tamás, Hideg, Kálmán, Kuppusamy, Periannan

“…The development of smart anticancer drugs that can selectively kill cancer cells while sparing the surrounding healthy tissues/cells is of paramount importance…”
Get full text

Anticancer efficacy of a difluorodiarylidenyl piperidone (HO-3867) in human ovarian cancer cells and tumor xenografts by Selvendiran, Karuppaiyah, Tong, Liyue, Bratasz, Anna, Kuppusamy, M Lakshmi, Ahmed, Shabnam, Ravi, Yazhini, Trigg, Nancy J, Rivera, Brian K, Kálai, Tamás, Hideg, Kálmán, Kuppusamy, Periannan

“…The purpose of this study was to evaluate the anticancer potency and mechanism of a novel difluorodiarylidenyl piperidone (H-4073) and its N-hydroxypyrroline…”
Get full text

HO-3867, a curcumin analog, sensitizes cisplatin-resistant ovarian carcinoma, leading to therapeutic synergy through STAT3 inhibition by Selvendiran, Karuppaiyah, Ahmed, Shabnam, Dayton, Alex, Kuppusamy, M. Lakshmi, Rivera, Brian K., Kálai, Tamás, Hideg, Kálmán, Kuppusamy, Periannan

“…Cisplatin resistance is a major obstacle in the treatment of ovarian cancer. Drug combinations with synergistic or complementary functions are a promising…”
Get full text

HO-3867, a synthetic compound, inhibits the migration and invasion of ovarian carcinoma cells through downregulation of fatty acid synthase and focal adhesion kinase by Selvendiran, Karuppaiyah, Ahmed, Shabnam, Dayton, Alex, Ravi, Yazhini, Kuppusamy, M Lakshmi, Bratasz, Anna, Rivera, Brian K, Kálai, Tamás, Hideg, Kálmán, Kuppusamy, Periannan

“…Fatty acid synthase (FAS) and focal adhesion kinase (FAK), which are overexpressed in a variety of human epithelial tumors, play a key role in the migration…”
Get full text

Inhibition of vascular smooth-muscle cell proliferation and arterial restenosis by HO-3867, a novel synthetic curcuminoid, through up-regulation of PTEN expression by Selvendiran, Karuppaiyah, Kuppusamy, M Lakshmi, Bratasz, Anna, Tong, Liyue, Rivera, Brian K, Rink, Cameron, Sen, Chandan K, Kálai, Tamás, Hideg, Kálmán, Kuppusamy, Periannan

“…Phosphatase and tensin homolog (PTEN), a tumor suppressor gene, has been shown to play a vital role in vascular smooth muscle cell (SMC) proliferation and…”
Get more information

Cellular uptake, retention and bioabsorption of HO-3867, a fluorinated curcumin analog with potential antitumor properties by Dayton, Alex, Selvendiran, Karuppaiyah, Kuppusamy, M. Lakshmi, Rivera, Brian K., Meduru, Sarath, Kálai, Tamás, Hideg, Kálmán, Kuppusamy, Periannan

“…Curcumin, a naturally-occurring compound found in the rhizome of Curcuma longa plant, is known for its antitumor activities. However, its clinical efficacy is…”
Get full text

Evaluating the efficacy of Seattle-PAP for the respiratory support of premature neonates: study protocol for a randomized controlled trial by Backes, Carl H, Notestine, Jennifer L, Lamp, Jane M, Balough, Jeanne C, Notestine, Allison M, Alfred, Crystal M, Kern, Juli M, Stenger, Michael R, Rivera, Brian K, Moallem, Mohannad, Miller, Randy R, Naik, Apurwa, Cooper, Jennifer N, Howard, Christopher R, Welty, Stephen E, Hillman, Noah H, Zupancic, John A F, Stanberry, Larissa I, Hansen, Thomas N, Smith, Charles V

“…At birth, the majority of neonates born at <30 weeks of gestation require respiratory support to facilitate transition and ensure adequate gas exchange…”
Get full text

Supplemental Oxygen Protects Heart Against Acute Myocardial Infarction by Prabhat, Anjali M, Kuppusamy, M Lakshmi, Naidu, Shan K, Meduru, Sarath, Reddy, Praneeth T, Dominic, Abishai, Khan, Mahmood, Rivera, Brian K, Kuppusamy, Periannan

“…Myocardial infarction (MI), which occurs often due to acute ischemia followed by reflow, is associated with irreversible loss (death) of cardiomyocytes. If…”
Get full text

Proactive neonatal treatment at 22 weeks of gestation: a systematic review and meta-analysis by Backes, Carl H., Rivera, Brian K., Pavlek, Leanne, Beer, Lindsey J., Ball, Molly K., Zettler, Eli T., Smith, Charles V., Bridge, Jeffrey A., Bell, Edward F., Frey, Heather A.

“…The objective of this study was to provide a systematic review and meta-analysis to quantify prognosis and identify factors associated with variations in…”
Get full text

Percutaneous Patent Ductus Arteriosus (PDA) Closure During Infancy: A Meta-analysis by Backes, Carl H, Rivera, Brian K, Bridge, Jeffrey A, Armstrong, Aimee K, Boe, Brian A, Berman, Darren P, Fick, Tyler, Holzer, Ralf J, Hijazi, Ziyad M, Abadir, Sylvia, Justino, Henri, Bergersen, Lisa, Smith, Charles V, Kirpalani, Haresh

“…Patent ductus arteriosus (PDA) is a precursor to morbidity and mortality. Percutaneous (catheter-based) closure is the procedure of choice for adults and older…”
Get full text

Pulmonary Vein Stenosis in Infants: A Systematic Review, Meta-Analysis, and Meta-Regression by Backes, Carl H., Nealon, Erin, Armstrong, Aimee K., Cua, Clifford L., Mitchell, Courtney, Krishnan, Usha, Vanderlaan, Rachel D., Song, Mi Kyoung, Viola, Nicola, Smith, Charles V., McConnell, Patrick I., Rivera, Brian K., Bridge, Jeffrey

“…To quantify outcomes of infants (<1 year of age) diagnosed with pulmonary vein stenosis (PVS). MEDLINE (PubMed), Scopus, and Web of Science were searched…”
Get full text

Placental Transfusion Strategies in Very Preterm Neonates: A Systematic Review and Meta-analysis by Backes, Carl H., Rivera, Brian K., Haque, Urbee, Bridge, Jeffrey A., Smith, Charles V., Hutchon, David J. R., Mercer, Judith S.

“…OBJECTIVE:To investigate the effects of interventions promoting placental transfusion at delivery (delayed cord clamping or umbilical cord milking) compared…”
Get full text

Association of the respiratory severity score with bronchopulmonary dysplasia-associated pulmonary hypertension in infants born extremely preterm by Beer, Lindsey, Rivera, Brian K., Jama, Waceys, Slaughter, Jonathan L., Backes, Carl H., Conroy, Sara, Kielt, Matthew J.

“…Objective To test the hypothesis that elevations in the respiratory severity score (RSS) are associated with increased probability of bronchopulmonary…”
Get full text

Umbilical cord clamping among infants with a prenatal diagnosis of congenital heart disease by Fite, Elliott L., Rivera, Brian K., McNabb, Riley, Smith, Charles V., Hill, Kevin D., Katheria, Anup, Maitre, Nathalie, Backes, Carl H.

Get full text

Synthesis of N-Substituted 3,5-Bis(arylidene)-4-piperidones with High Antitumor and Antioxidant Activity by Kálai, Tamás, Kuppusamy, M. Lakshmi, Balog, Mária, Selvendiran, Karuppaiyah, Rivera, Brian K, Kuppusamy, Periannan, Hideg, Kálmán

“…A series of 3,5-bis(arylidene)-4-piperidone (DAP) compounds are considered as synthetic analogues of curcumin for anticancer properties. We performed…”
Get full text

Evaluating the evidence behind umbilical cord clamping practices in at-risk neonatal populations by Bitler, Chelsea K., Rivera, Brian K., Godavarthi, Srikruthi, Stehle, Carolyn G., Smith, Charles V., Halling, Cecilie, Backes, Carl H.

“…Umbilical cord clamping practices impact nearly 140 million births each year. Current evidence has led professional organizations to recommend delayed cord…”
Get full text