Oral human papillomavirus infection among drug users in Puerto Rico

The prevalence of human papillomavirus (HPV) in the oral cavity has not been as well studied as genital infection and its prevalence among drug users is uncertain. This study describes the prevalence and correlates of oral HPV infection among a sample of drug users in Puerto Rico (PR). Cross-section...

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Bibliographic Details
Published in:	Puerto Rico health sciences journal Vol. 33; no. 4; pp. 190 - 196
Main Authors:	Ortiz, Ana P, Reyes, Juan C, Palefsky, Joel, Negrón, Juan, Da Costa, María, Vázquez, Myrna, Rivera, Arodis I, Matos, Tomás D, Rios-Olivares, Eddy, Tortolero, Guillermo
Format:	Journal Article
Language:	English
Published:	Puerto Rico Universidad de Puerto Rico, Recinto de Ciencias Medicas 01-12-2014
Subjects:	Adolescent Adult Alcoholism - epidemiology Alphapapillomavirus - isolation & purification Comorbidity Cross-Sectional Studies DNA, Viral - analysis Female HIV Seropositivity - epidemiology Human Papillomavirus DNA Tests Humans Male Mouth - virology Papillomavirus Infections - epidemiology Papillomavirus Infections - virology Prisoners Puerto Rico - epidemiology Risk Factors Sampling Studies Sex Work Sexual Behavior Socioeconomic Factors Stomatitis - epidemiology Stomatitis - virology Stress, Psychological - epidemiology Substance-Related Disorders - epidemiology Young Adult Puerto Rico
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Summary:	The prevalence of human papillomavirus (HPV) in the oral cavity has not been as well studied as genital infection and its prevalence among drug users is uncertain. This study describes the prevalence and correlates of oral HPV infection among a sample of drug users in Puerto Rico (PR). Cross-sectional study of 271 drug users aged 18-35 years, not undergoing substance abuse treatment, living in the San Juan metropolitan area. Oral samples were collected through an oral rinse and HPV infection status was detected through PCR and HPV typing. Information on covariates was obtained through face-to-face interviews and serum analyses. A total of 34 participants were positive for any HPV type (12.5%), whereas 13 individuals (4.8%) were positive for one of the 38 type-specific HPV probes evaluated. Among those HPV positive, the most common HPV type detected was non-oncogenic HPV 72 (11.8%, n = 4). Oncogenic HPV types detected were 35 (5.9%) and 56 (2.9%). Factors associated with oral HPV infection included binge drinking (OR = 3.85, 95% CI = 1.40, 10.58), HIV positivity (OR = 4.67, 95% CI = 1.58, 13.74) and ever having engaged in commercial sex (OR = 3.55, 95% CI = 1.46, 8.67); infection did not differ by age or gender. Consistent with previous studies in the genital and oral tract, HIV infection, alcohol abuse and commercial sex practices were strongly associated with oral HPV infection. Future studies should assess the implications of oral HPV infection on oral cancer risk in this population.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0738-0658