Search Results - "Rivella, S"

Polycythemia is associated with bone loss and reduced osteoblast activity in mice by Oikonomidou, P. R., Casu, C., Yang, Z., Crielaard, B., Shim, J. H., Rivella, S., Vogiatzi, M. G.

“…Summary Increased fragility has been described in humans with polycythemia vera (PV). Herein, we describe an osteoporotic phenotype associated with decreased…”
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P1520: AN ACTIVIN RECEPTOR IIB LIGAND TRAP, IN COMBINATION WITH TMPRSS6 INDUCED IRON‐RESTRICTION, IS A SUPERIOR TREATMENT FOR CORRECTING Β‐THALASSEMIA IN MICE by Guerra, A., Demsko, P., Sinha, S., McVeigh, P., Castruccio Castracani, C., Breda, L., Casu, C., Guo, S., Rivella, S.

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S101: COMBINATION OF A LUSPATERCEPT‐LIKE DRUG (RAP‐GRL) AND TMPRSS6‐ASO IS SUPERIOR TO EITHER DRUG ALONE FOR CORRECTING β‐THALASSEMIA by Guerra, A., Demsko, P., Sinha, S., McVeigh, P., Castruccio Castracani, C., Breda, L., Casu, C., Rivella, S.

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S102: OBLIGATE N‐TERMINAL BUT NOT C‐TERMINAL MONOFERRIC TRANSFERRIN AMELIORATES ANEMIA IN β‐THALASSEMIC MICE by Guerra, A., Parrow, N.L., McVeigh, P., Fleming, R.E., Ginzburg, Y.Z., Rivella, S.

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P1509: BONE MARROW TFR2 GENETIC DELETION ABROGATES BLOOD TRANFUSION REQUIREMENT IN THE HBBTH1/TH2 Β‐THALASSEMIC MURINE MODEL by Di Modica, S. M., Tanzi, E., Olivari, V., Lidonnici, M. R., Pettinato, M., Pagani, A., Tiboni, F., Ferrari, G., Silvestri, L., Rivella, S., Nai, A.

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P1521: A SEVERE MOUSE MODEL OF ALPHA‐THALASSEMIA SHOWS ABNORMAL IRON METABOLISM, ERYTHROPOIESIS AND COAGULATION, AND CAN BE RESCUED BY A NOVEL GENE THERAPY APPROACH by Rivella, S., Chappell, M., Jarocha, D., Breda, L., Ghiaccio, V., Fedorky, M., Triebwasser, M., Guerra, A., Gollomp, K., Teawtrakul, N., Glentis, S., Kattamis, A., Abdulmalik, O.

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S104: A SEVERE MOUSE MODEL OF ALPHA‐THALASSEMIA SHOWS ABNORMAL IRON METABOLISM, ERYTHROPOIESIS AND COAGULATION, AND CAN BE RESCUED BY A NOVEL GENE THERAPY APPROACH by Chappell, M, Breda, L, Guerra, A, Ghiaccio, V, Fedorky, M, Jarocha, D, Gollomp, K, Teawtrakul, N, Glentis, S, Kattamis, A, Rivella, S

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Genetic treatment of severe hemoglobinopathies: the combat against transgene variegation and transgene silencing by Rivella, S, Sadelain, M

“…Gene addition strategies are rational approaches to the treatment of sickle cell anemia and thalassemia. The goal of such genetic treatments is to introduce a…”
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thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapies by Rivella, S.

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Non-transfusion-dependent thalassemias by Musallam, Khaled M, Rivella, Stefano, Vichinsky, Elliott, Rachmilewitz, Eliezer A

“…Non-transfusion-dependent thalassemias include a variety of phenotypes that, unlike patients with beta (β)-thalassemia major, do not require regular…”
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Transcriptional Organization of a 450-kb Region of the Human X Chromosome in Xq28 by Bione, S., Tamanini, F., Maestrini, E., Tribioli, C., Poustka, A., Torri, G., Rivella, S., Toniolo, D.

“…In this paper, we report the transcriptional organization of a 450-kb gene cluster in Xq28, flanked by the glucose-6-phosphate dehydrogenase and the color…”
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Combination of Tmprss6- ASO and the iron chelator deferiprone improves erythropoiesis and reduces iron overload in a mouse model of beta-thalassemia intermedia by Casu, Carla, Aghajan, Mariam, Oikonomidou, Paraskevi Rea, Guo, Shuling, Monia, Brett P, Rivella, Stefano

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The murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized mice by Casanovas, Guillem, Vujić Spasic, Maja, Casu, Carla, Rivella, Stefano, Strelau, Jens, Unsicker, Klaus, Muckenthaler, Martina U

“…In conditions of increased erythropoiesis, expression of hepcidin, the master regulator of systemic iron homeostasis, is decreased to allow for the release of…”
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Mapping of two genes encoding isoforms of the actin binding protein ABP-280, a dystrophin like protein, to Xq28 and to chromosome 7 by Maestrini, E, Patrosso, C, Mancini, M, Rivella, S, Rocchi, M, Repetto, M, Villa, A, Frattini, A, Zoppè, M, Vezzoni, P

“…ABP-280 is a ubiquitous actin binding protein present in the cytoskeleton of many different cell types. ABP-280 was mapped to distal Xq28, 50-60 kb downstream…”
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Isolation of new genes in distal Xq28: transcriptional map and identification of a human homologue of the ARD1 N-acetyl transferase of Saccharomyces cerevisiae by Tribioli, C, Mancini, M, Plassart, E, Bione, S, Rivella, S, Sala, C, Torri, G, Toniolo, D

“…In this paper, we describe the physical and transcriptional organization of a region of 140 kb in Xq28, 5' to the L1CAM gene. By isolation and mapping of CpG…”
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Hepcidin is regulated by promoter-associated histone acetylation and HDAC3 by Pasricha, Sant-Rayn, Lim, Pei Jin, Duarte, Tiago L., Casu, Carla, Oosterhuis, Dorenda, Mleczko-Sanecka, Katarzyna, Suciu, Maria, Da Silva, Ana Rita, Al-Hourani, Kinda, Arezes, João, McHugh, Kirsty, Gooding, Sarah, Frost, Joe N., Wray, Katherine, Santos, Ana, Porto, Graça, Repapi, Emmanouela, Gray, Nicki, Draper, Simon J., Ashley, Neil, Soilleux, Elizabeth, Olinga, Peter, Muckenthaler, Martina U., Hughes, Jim R., Rivella, Stefano, Milne, Thomas A., Armitage, Andrew E., Drakesmith, Hal

“…Hepcidin regulates systemic iron homeostasis. Suppression of hepcidin expression occurs physiologically in iron deficiency and increased erythropoiesis but is…”
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S101: COMBINATION OF A LUSPATERCEPT-LIKE DRUG (RAP-GRL) AND TMPRSS6-ASO IS SUPERIOR TO EITHER DRUG ALONE FOR CORRECTING β-THALASSEMIA by Guerra, A., Demsko, P., Sinha, S., McVeigh, P., Castruccio Castracani, C., Breda, L., Casu, C., Rivella, S.

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A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human β-globin gene transfer by Rivella, Stefano, May, Chad, Chadburn, Amy, Rivière, Isabelle, Sadelain, Michel

“…Patients affected by β-thalassemia major require lifelong transfusions because of insufficient or absent production of the β chain of hemoglobin (Hb). A…”
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Successful treatment of murine β-thalassemia intermedia by transfer of the human β-globin gene by May, Chad, Rivella, Stefano, Chadburn, Amy, Sadelain, Michel

“…The β-thalassemias are caused by more than 200 mutations that reduce or abolish β-globin production. The severity of the resulting anemia can lead to lifelong…”
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S104: A SEVERE MOUSE MODEL OF ALPHA-THALASSEMIA SHOWS ABNORMAL IRON METABOLISM, ERYTHROPOIESIS AND COAGULATION, AND CAN BE RESCUED BY A NOVEL GENE THERAPY APPROACH by Chappell, M, Breda, L, Guerra, A, Ghiaccio, V, Fedorky, M, Jarocha, D, Gollomp, K, Teawtrakul, N, Glentis, S, Kattamis, A, Rivella, S

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