Search Results - "Rivat, Cyril"

The dark side of opioids in pain management: basic science explains clinical observation by Rivat, Cyril, Ballantyne, Jane

“…In the past 2 decades, opioids have been used increasingly for the treatment of persistent pain, and doses have tended to creep up. As basic science elucidates…”
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AAV2/9-mediated silencing of PMP22 prevents the development of pathological features in a rat model of Charcot-Marie-Tooth disease 1 A by Gautier, Benoit, Hajjar, Helene, Soares, Sylvia, Berthelot, Jade, Deck, Marie, Abbou, Scarlette, Campbell, Graham, Ceprian, Maria, Gonzalez, Sergio, Fovet, Claire-Maëlle, Schütza, Vlad, Jouvenel, Antoine, Rivat, Cyril, Zerah, Michel, François, Virginie, Le Guiner, Caroline, Aubourg, Patrick, Fledrich, Robert, Tricaud, Nicolas

“…Charcot-Marie-Tooth disease 1 A (CMT1A) results from a duplication of the PMP22 gene in Schwann cells and a deficit of myelination in peripheral nerves…”
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JAK/STAT3 pathway is activated in spinal cord microglia after peripheral nerve injury and contributes to neuropathic pain development in rat by Dominguez, Elisa, Rivat, Cyril, Pommier, Blandine, Mauborgne, Annie, Pohl, Michel

“…Peripheral nerve lesion leads to the production of interleukin 6 (IL-6)-related neuropoietic cytokines involved in nerve protection and regeneration. This…”
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Opioid and chemokine receptor crosstalk: a promising target for pain therapy? by Parsadaniantz, Stéphane Mélik, Rivat, Cyril, Rostène, William, Goazigo, Annabelle Réaux-Le

“…Chemokine receptors and opioid receptors in nociceptive pathways interact in ways that can alter opioid function. In this Progress article, Réaux-Le Goazigo…”
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Neuron-associated macrophage proliferation in the sensory ganglia is associated with peripheral nerve injury-induced neuropathic pain involving CX3CR1 signaling by Guimarães, Rafaela M, Aníbal-Silva, Conceição E, Davoli-Ferreira, Marcela, Gomes, Francisco Isaac F, Mendes, Atlante, Cavallini, Maria C M, Fonseca, Miriam M, Damasceno, Samara, Andrade, Larissa P, Colonna, Marco, Rivat, Cyril, Cunha, Fernando Q, Alves-Filho, José C, Cunha, Thiago M

“…Resident macrophages are distributed across all tissues and are highly heterogeneous due to adaptation to different tissue-specific environments. The resident…”
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Persistent Postsurgical Pain by Richebé, Philippe, Capdevila, Xavier, Rivat, Cyril

“…Abstract The development of chronic pain is considered a major complication after surgery. Basic science research in animal models helps us understand the…”
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Vulnerability to depression: from brain neuroplasticity to identification of biomarkers by Blugeot, Aurélie, Rivat, Cyril, Bouvier, Elodie, Molet, Jenny, Mouchard, Amandine, Zeau, Brigitte, Bernard, Christophe, Benoliel, Jean-Jacques, Becker, Chrystel

“…A stressful event increases the risk of developing depression later in life, but the possible predisposing factors remain unknown. Our study aims to…”
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FLT3 signaling inhibition abrogates opioid tolerance and hyperalgesia while preserving analgesia by Jouvenel, Antoine, Tassou, Adrien, Thouaye, Maxime, Ruel, Jérôme, Antri, Myriam, Leyris, Jean-Philippe, Giraudin, Aurore, Mallié, Sylvie, Sar, Chamroeum, Diouloufet, Lucie, Sonrier, Corinne, Daubeuf, François, Bertin, Juliette, Alves, Stacy, Ventéo, Stéphanie, Frossard, Nelly, Carroll, Patrick, Mechaly, Ilana, Rognan, Didier, Sokoloff, Pierre, Dallel, Radhouane, Delmas, Patrick, Valmier, Jean, Rivat, Cyril

“…Navigating the duality of opioids’ potent analgesia and side effects, including tolerance and hyperalgesia, is a significant challenge in chronic pain…”
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Inhibition of neuronal FLT3 receptor tyrosine kinase alleviates peripheral neuropathic pain in mice by Rivat, Cyril, Sar, Chamroeun, Mechaly, Ilana, Leyris, Jean-Philippe, Diouloufet, Lucie, Sonrier, Corinne, Philipson, Yann, Lucas, Olivier, Mallié, Sylvie, Jouvenel, Antoine, Tassou, Adrien, Haton, Henri, Venteo, Stéphanie, Pin, Jean-Philippe, Trinquet, Eric, Charrier-Savournin, Fabienne, Mezghrani, Alexandre, Joly, Willy, Mion, Julie, Schmitt, Martine, Pattyn, Alexandre, Marmigère, Frédéric, Sokoloff, Pierre, Carroll, Patrick, Rognan, Didier, Valmier, Jean

“…Peripheral neuropathic pain (PNP) is a debilitating and intractable chronic disease, for which sensitization of somatosensory neurons present in dorsal root…”
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Cellular and subcellular localization of CXCL12 and CXCR4 in rat nociceptive structures: physiological relevance by Reaux-Le Goazigo, Annabelle, Rivat, Cyril, Kitabgi, Patrick, Pohl, Michel, Melik Parsadaniantz, Stéphane

“…Initial studies implicated the chemokine CXC motif ligand 12 (CXCL12) and its cognate CXC motif receptor 4 (CXCR4) in pain modulation. However, there has been…”
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A proliferation‐inducing ligand–mediated anti‐inflammatory response of astrocytes in multiple sclerosis by Baert, Laurie, Benkhoucha, Mahdia, Popa, Natalia, Ahmed, Mashal C., Manfroi, Benoit, Boutonnat, Jean, Sturm, Nathalie, Raguenez, Gilda, Tessier, Marine, Casez, Olivier, Marignier, Romain, Ahmadi, Mitra, Broisat, Alexis, Ghezzi, Catherine, Rivat, Cyril, Sonrier, Corinne, Hahne, Michael, Baeten, Dominique, Vives, Romain R., Lortat‐Jacob, Hugues, Marche, Patrice N., Schneider, Pascal, Lassmann, Hans P., Boucraut, Jose, Lalive, Patrice H., Huard, Bertrand

“…Objective The two related tumor necrosis factor members a proliferation‐inducing ligand (APRIL) and B‐cell activation factor (BAFF) are currently targeted in…”
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Intravenous Acetaminophen as an Adjunct Analgesic in Cardiac Surgery Reduces Opioid Consumption, But Not Opioid Related Adverse Effects: A Randomized Controlled Trial by Jelacic, Srdjan, MD, Bollag, Laurent, MD, Bowdle, Andrew, MD PhD, Rivat, Cyril, PhD, Cain, Kevin C., PhD, Richebe, Philippe, MD PhD

“…Objectives Our hypothesis was that intravenous acetaminophen as an adjunct analgesic will significantly decrease 24 hour postoperative opioid consumption…”
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Zeb Family Members and Boundary Cap Cells Underlie Developmental Plasticity of Sensory Nociceptive Neurons by Ohayon, David, Ventéo, Stéphanie, Sonrier, Corinne, Lafon, Pierre-André, Garcès, Alain, Valmier, Jean, Rivat, Cyril, Topilko, Piotr, Carroll, Patrick, Pattyn, Alexandre

“…Dorsal root ganglia (DRG) sensory neurons arise from heterogeneous precursors that differentiate in two neurogenic waves, respectively controlled by Neurog2…”
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FXYD2 antisense oligonucleotide provides an efficient approach for long-lasting relief of chronic peripheral pain by Derre, Alexandre, Soler, Noelian, Billoux, Valentine, Benizri, Sebastien, Vialet, Brune, Rivat, Cyril, Barthélémy, Philippe, Carroll, Patrick, Pattyn, Alexandre, Venteo, Stephanie

“…Chronic pain, whether of inflammatory or neuropathic origin, affects about 18% of the population of developed countries, and most current treatments are only…”
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Target-Controlled Dosing of Remifentanil During Cardiac Surgery Reduces Postoperative Hyperalgesia by Richebé, Philippe, MD, PhD, Pouquet, Olivier, MD, Jelacic, Srdjan, MD, Mehta, Sonya, MD, Calderon, Joachim, MD, Picard, Walter, MD, Rivat, Cyril, PhD, Cahana, Alex, MD, DAAPM, FIPP, MAS, Janvier, Gérard, MD, PhD

“…Objective One of the strategies to attenuate opioid-induced hyperalgesia (OIH) may be to decrease intraoperative doses of opioids by using target-controlled…”
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Ketamine improves the management of exaggerated postoperative pain observed in perioperative fentanyl-treated rats by RICHEBE, Philippe, RIVAT, Cyril, LAULIN, Jean-Paul, MAURETTE, Pierre, SIMONNET, Guy

“…Although opioids are unsurpassed analgesics, experimental and clinical studies suggest that opioids activate N-methyl-d-aspartate pronociceptive systems…”
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NOV/CCN3 attenuates inflammatory pain through regulation of matrix metalloproteinases-2 and -9 by Kular, Lara, Rivat, Cyril, Lelongt, Brigitte, Calmel, Claire, Laurent, Maryvonne, Pohl, Michel, Kitabgi, Patrick, Melik-Parsadaniantz, Stéphane, Martinerie, Cécile

“…Sustained neuroinflammation strongly contributes to the pathogenesis of pain. The clinical challenge of chronic pain relief led to the identification of…”
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The Role of Ketamine in Preventing Fentanyl-Induced Hyperalgesia and Subsequent Acute Morphine Tolerance by Laulin, Jean-Paul, Maurette, Pierre, Corcuff, Jean-Benoît, Rivat, Cyril, Chauvin, Marcel, Simonnet, Guy

“…Perioperative opioids increase postoperative pain and morphine requirement, suggesting acute opioid tolerance. Furthermore, opioids elicit N-methyl-d-aspartate…”
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Spinal NK-1 receptor-expressing neurons and descending pathways support fentanyl-induced pain hypersensitivity in a rat model of postoperative pain by Rivat, Cyril, Vera-Portocarrero, Louis P., Ibrahim, Mohab M., Mata, Heriberto P., Stagg, Nicola J., De Felice, Milena, Porreca, Frank, Malan, T. P.

“…The clinically important opioid fentanyl, administered acutely, enhances mechanical hypersensitivity in a model of surgical pain induced by plantar incision…”
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Sciatic nerve block fails in preventing the development of late stress-induced hyperalgesia when high-dose fentanyl is administered perioperatively in rats by Méleine, Mathieu, Rivat, Cyril, Laboureyras, Emilie, Cahana, Alex, Richebé, Philippe

“…: Sciatic nerve block fails in preventing the development of late stress-induced hyperalgesia (SIH) when high-dose fentanyl is administered perioperatively in…”
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