Does trail making test predict long-term prognosis in older patients with COPD?

Executive abilities are frequently impaired in patients with chronic obstructive pulmonary disease (COPD). We aimed at investigating the association between trail making test (TMT) and survival. Our series consisted of 68 stable COPD outpatients followed-up every 6 months for 52.6 ± 27.6 months. Enr...

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Bibliographic Details
Published in:	Aging clinical and experimental research Vol. 33; no. 6; pp. 1699 - 1703
Main Authors:	Fumagalli, Alessia, Misuraca, Clementina, Riva, Sonia, Soraci, Luca, Fabbietti, Paolo, Di Rosa, Mirko, Corsonello, Andrea, Lattanzio, Fabrizia, Colombo, Daniele
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 01-06-2021 Springer Nature B.V
Subjects:	Chronic obstructive pulmonary disease Geriatrics/Gerontology Medical prognosis Medicine Medicine & Public Health Mortality Neuropsychology Short Communication Executive dysfunction Chronic obstructive pulmonary disease Outpatients Trail making test Cognitive impairment Older
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Summary:	Executive abilities are frequently impaired in patients with chronic obstructive pulmonary disease (COPD). We aimed at investigating the association between trail making test (TMT) and survival. Our series consisted of 68 stable COPD outpatients followed-up every 6 months for 52.6 ± 27.6 months. Enrolled patients underwent a baseline comprehensive neuropsychological assessment, including mini - mental state exam, attentional matrices, digit span, Rey auditory verbal learning, Rey–Osterrieth complex figure, copy drawing, tokens test, verbal fluency, category fluency, frontal assessment battery, Raven’s progressive matrices, TMT-A, -B and -B-A. The association between neuropsychological deficits and overall mortality was investigated by Cox regression. During follow-up period, 41 patients (60.3%) died. After adjusting for potential confounders, TMT-B was significantly associated with mortality (HR = 2.42, 95% CI = 1.10–5.31), along with age (HR = 1.06, 95% CI = 1.0–1.13), overall comorbidity (HR = 1.29, 95% CI = 1.02–1.62) and use of noninvasive ventilation (HR = 2.16, 95% CI = 1.05–4.45). Defective TMT-B may be associated with long-term mortality in patients with stable COPD.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1720-8319 1594-0667 1720-8319
DOI:	10.1007/s40520-020-01680-3