Streptozotocin-induced diabetes lowers retinol-binding protein and transthyretin concentrations in rats

Retinol-binding protein (RBP) and transthyretin (TTR) in the plasma, liver and kidney, retinol in plasma, and total vitamin A in the liver were measured in rats 6 weeks after diabetes mellitus had been induced by streptozotocin (STZ). The diabetic rats gained 83% less weight despite consuming 45% mo...

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Bibliographic Details
Published in:	British journal of nutrition Vol. 76; no. 6; pp. 891 - 897
Main Authors:	Tuitoek, P. J., Rittere, S. J., Smitha, J. E., Basu, T. K.
Format:	Journal Article
Language:	English
Published:	Cambridge, UK Cambridge University Press 01-12-1996
Subjects:	Animals Biological and medical sciences Body Weight Diabetes mellitns Diabetes Mellitus, Experimental - metabolism Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Energy Intake Etiopathogenesis. Screening. Investigations. Target tissue resistance General Nutrition Kidney - metabolism Liver - metabolism Male Medical sciences Prealbumin - metabolism Rats Rats, Wistar Retinol-binding protein Retinol-Binding Proteins - metabolism Retinol-Binding Proteins, Plasma Streptozotocin Transthyretin Vitamin A Vitamin A - metabolism Vitamin A Streptozotocin Diabetes mellitns Transthyretin Retinol-binding protein Endocrinopathy Rat Diabetes mellitus Rodentia Vitamin Retinol Binding protein Vertebrata Experimental disease Mammalia Thyroxine binding prealbumin Animal Carrier protein
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Summary:	Retinol-binding protein (RBP) and transthyretin (TTR) in the plasma, liver and kidney, retinol in plasma, and total vitamin A in the liver were measured in rats 6 weeks after diabetes mellitus had been induced by streptozotocin (STZ). The diabetic rats gained 83% less weight despite consuming 45% more feed than the non-diabetic controls. Plasma and kidney concentrations of RBP and TTR were significantly lower in diabetic than in the non-diabetic control rats. Unlike the retinol carrier proteins, plasma albumin concentrations remained unaffected. Plasma concentrations of retino1 were decreased while its hepatic levels increased in the diabeticanimals. The depressed circulatory levels of retinol may reflect an altered metabolism of its transport proteins
Bibliography:	For reprints ark:/67375/6GQ-C68M145Q-F PII:S0007114596001985 ArticleID:00198 istex:BC69861F69077FA231CE8AB54AE3B34ECDA6763C ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0007-1145 1475-2662
DOI:	10.1079/BJN19960095