Studies on the Immunization of White Mice Against Infections with Bacterium Tularense

The successful immunization of white mice against challenge with Bacterium tularense is described. The immunization procedure consisted of a single intraperitoneal injection of 0.1 ml of an ether-extracted vaccine. Four strains of B. tularense differing markedly in virulence were of equal potency wh...

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Bibliographic Details
Published in:	The Journal of immunology (1950) Vol. 69; no. 5; pp. 515 - 524
Main Authors:	Frederick Bell, J, Larson, Carl L, Wicht, W. C, Ritter, Sara S
Format:	Journal Article
Language:	English
Published:	United States Am Assoc Immnol 01-11-1952
Subjects:	Animals Francisella tularensis Immunization Mice Old Medline Vaccination PASTEURELLA TULARENSIS
Online Access:	Get full text
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Summary:	The successful immunization of white mice against challenge with Bacterium tularense is described. The immunization procedure consisted of a single intraperitoneal injection of 0.1 ml of an ether-extracted vaccine. Four strains of B. tularense differing markedly in virulence were of equal potency when used as vaccines. The mice should be at least 40 days old when vaccinated. Considerable immunity was apparent when the mice were subsequently challenged subcutaneously with serial 10-fold dilutions of a strain of B. tularense which possessed full virulence for mice but diminished virulence for rabbits. The protection conferred upon immunized mice was measured by the differences in LD50 titers of the control and vaccinated groups of mice.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0022-1767 1550-6606
DOI:	10.4049/jimmunol.69.5.515