Search Results - "Ritson, Dougal"

Common origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism by Patel, Bhavesh H., Percivalle, Claudia, Ritson, Dougal J., Duffy, Colm D., Sutherland, John D.

“…A minimal cell can be thought of as comprising informational, compartment-forming and metabolic subsystems. To imagine the abiotic assembly of such an overall…”
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Thiophosphate photochemistry enables prebiotic access to sugars and terpenoid precursors by Ritson, Dougal J., Sutherland, John D.

“…Over the past few years, evidence has accrued that demonstrates that terrestrial photochemical reactions could have provided numerous (proto)biomolecules with…”
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Synthesis of Aldehydic Ribonucleotide and Amino Acid Precursors by Photoredox Chemistry by Ritson, Dougal J., Sutherland, John D.

“…Light work: UV irradiation of a system formed by adding copper(I) cyanide to an aqueous solution of glycolonitrile, sodium phosphate, and hydrogen sulfide…”
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Mimicking the surface and prebiotic chemistry of early Earth using flow chemistry by Ritson, Dougal J., Battilocchio, Claudio, Ley, Steven V., Sutherland, John D.

“…When considering life’s aetiology, the first questions that must be addressed are “how?” and “where?” were ostensibly complex molecules, considered necessary…”
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A cyanosulfidic origin of the Krebs cycle by Ritson, Dougal J.

“…All four cellular subsystems can be provided under compatible prebiotic conditions. The centrality of the Krebs cycle in metabolism has long been interpreted…”
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Supply of phosphate to early Earth by photogeochemistry after meteoritic weathering by Ritson, Dougal J., Mojzsis, Stephen J., Sutherland, John. D.

“…During terrestrial differentiation, the relatively small amount of phosphorus that migrated to the lithosphere was incorporated into igneous rock,…”
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Azoles as Auxiliaries and Intermediates in Prebiotic Nucleoside Synthesis by Ritson, Dougal J., Poplawski, Mikolaj W., Bond, Andrew D., Sutherland, John D.

“…4,5-Dicyanoimidazole and 2-aminothiazole are azoles that have previously been implicated in prebiotic nucleotide synthesis. The former compound is a byproduct…”
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Timescales for Prebiotic Photochemistry Under Realistic Surface Ultraviolet Conditions by Rimmer, Paul B, Thompson, Samantha J, Xu, Jianfeng, Russell, David A, Green, Nicholas J, Ritson, Dougal J, Sutherland, John D, Queloz, Didier P

“…Ultraviolet (UV) light has long been invoked as a source of energy for prebiotic chemical synthesis, but experimental support does not involve sources of UV…”
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Conversion of Biosynthetic Precursors of RNA to Those of DNA by Photoredox Chemistry by Ritson, Dougal J., Sutherland, John D.

“…Soon after the origin of RNA-based life, depletion of prebiotically synthesised ribonucleotides would have driven the evolution of a biosynthetic pathway to…”
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Tuneable DNA-based asymmetric catalysis using a G-quadruplex supramolecular assembly by Roe, Stephen, Ritson, Dougal J, Garner, Tom, Searle, Mark, Moses, John E

“…Described is the first modular construction of a G-quadruplex chiral catalyst. The key objective was to use G-quadruplex structures to act as chiral ligands…”
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Do sulfate radicals really enable a non-enzymatic Krebs cycle precursor? by Sutherland, John, Ritson, Dougal

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A fragment based click chemistry approach towards hybrid G-quadruplex ligands: design, synthesis and biophysical evaluation by Ritson, Dougal J., Moses, John E.

“…A library of hybrid oxazole–triazole based compounds containing contiguously linked aromatic units were synthesised as G-quadruplex binding ligands. The design…”
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A synthetic approach to kingianin A based on biosynthetic speculation by Sharma, Pallavi, Ritson, Dougal J, Burnley, James, Moses, John E

“…A synthetic approach towards the structurally complex dimer, kingianin A is reported. The strategy involved a cascade of complexity generating reactions,…”
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An efficient entry to 1,2-benzisoxazoles via 1,3-dipolar cycloaddition of in situ generated nitrile oxides and benzyne by Spiteri, Christian, Mason, Christopher, Zhang, Fengzhi, Ritson, Dougal J, Sharma, Pallavi, Keeling, Steve, Moses, John E

“…An efficient protocol for the synthesis of a range of 1,2-benzisoxazoles using an improved 1,3-dipolar cycloaddition of nitrile oxides and benzyne is…”
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A Silver-Mediated One-Step Synthesis of Oxazoles by Ritson, Dougal J, Spiteri, Christian, Moses, John E

“…A silver-mediated one-step procedure to 2,4-disubstituted and 2,4,5-trisubstituted oxazoles has been developed. The method is complementary to existing…”
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Room temperature palladium catalysed coupling of acyl chlorides with terminal alkynes by Cox, Russell J, Ritson, Dougal J, Dane, Thomas A, Berge, John, Charmant, Jonathan P H, Kantacha, Anob

“…Conditions are reported for the facile, high-yielding coupling of acyl chlorides with terminal alkynes in a reaction involving palladium and copper iodide; the…”
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A click chemistry approach to C3 symmetric, G-quadruplex stabilising ligands by Moses, John E, Ritson, Dougal J, Zhang, Fengzhi, Lombardo, Caterina Maria, Haider, Shozeb, Oldham, Neil, Neidle, Stephen

“…Described is the structure-based design and synthesis of a series of tris-triazole G-quadruplex binding ligands utilising the copper catalysed azide-alkyne…”
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Structure-Based Organic Synthesis of a Tricyclic N-Malayamycin Analogue by Hanessian, Stephen, Ritson, Dougal J

“…The solid-state structure of crystalline malayamycin A reveals a urea substituent that bisects the plane of the chairlike tetrahydropyran subunit. On the basis…”
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A Low-Waste Process To Sertraline By Diastereomeric Crystal Resolution and Waste Isomer Racemisation by Blacker, A. John, Brown, Stuart, Clique, Blandine, Gourlay, Brian, Headley, Catherine E, Ingham, Stephen, Ritson, Dougal, Screen, Thomas, Stirling, Matthew J, Taylor, David, Thompson, Gary

“…A semi-continuous method for recovering waste sertraline isomers from a diastereomeric crystallisation process is described in which the mother liquors from a…”
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Prebiotic synthesis of simple sugars by photoredox systems chemistry by Ritson, Dougal, Sutherland, John D.

“…A recent synthesis of activated pyrimidine ribonucleotides under prebiotically plausible conditions relied on mixed oxygenous and nitrogenous systems…”
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