Search Results - "Ritchie, James W. A."

A framework for the development of effective anti-metastatic agents by Anderson, Robin L., Balasas, Theo, Callaghan, Juliana, Coombes, R. Charles, Evans, Jeff, Hall, Jacqueline A., Kinrade, Sally, Jones, David, Jones, Paul S., Jones, Rob, Marshall, John F., Panico, Maria Beatrice, Shaw, Jacqui A., Steeg, Patricia S., Sullivan, Mark, Tong, Warwick, Westwell, Andrew D., Ritchie, James W. A.

“…Most cancer-related deaths are a result of metastasis, and thus the importance of this process as a target of therapy cannot be understated. By asking ‘how can…”
Get full text

The histone deacetylase inhibitor PXD101 synergises with 5-fluorouracil to inhibit colon cancer cell growth in vitro and in vivo by TUMBER, Anthony, COLLINS, Laura S, PETERSEN, Kamille Dumong, THOUGAARD, Annemette, CHRISTIANSEN, Sanne J, DEJLIGBJERG, Marielle, JENSEN, Peter Buhl, SEHESTED, Maxwell, RITCHIE, James W. A

“…Histone deacetylase inhibitors (HDACi) inhibit the growth of cancer cells, and combinations of HDACi with established chemotherapeutics can lead to synergistic…”
Get full text

Tryptophan and iodothyronine transport interactions in HepG2 human hepatoma cells by Ritchie, James W. A, Taylor, Peter Maving

“…This study identifies interactions between transport of the aromatic amino acid l-tryptophan (Trp) and thyroid hormones (TH) in HepG2 human hepatoma cells. The…”
Get full text

Novel amide derivatives as inhibitors of histone deacetylase: Design, synthesis and SAR by Andrianov, Victor, Gailite, Vija, Lola, Daina, Loza, Einars, Semenikhina, Valentina, Kalvinsh, Ivars, Finn, Paul, Petersen, Kamille Dumong, Ritchie, James W.A., Khan, Nagma, Tumber, Anthony, Collins, Laura S., Vadlamudi, Sree M., Björkling, Fredrik, Sehested, Maxwell

“…Enzymatic inhibition of histone deacetylase (HDAC) activity is emerging as an innovative and effective approach for the treatment of cancer. A series of novel…”
Get full text

A Cancer Research UK First Time in Human Phase I Trial of IMA950 (Novel Multipeptide Therapeutic Vaccine) in Patients with Newly Diagnosed Glioblastoma by Rampling, Roy, Peoples, Sharon, Mulholland, Paul J, James, Allan, Al-Salihi, Omar, Twelves, Christopher J, McBain, Catherine, Jefferies, Sarah, Jackson, Alan, Stewart, Willie, Lindner, Juha, Kutscher, Sarah, Hilf, Norbert, McGuigan, Lesley, Peters, Jane, Hill, Karen, Schoor, Oliver, Singh-Jasuja, Harpreet, Halford, Sarah E, Ritchie, James W A

“…To perform a two-cohort, phase I safety and immunogenicity study of IMA950 in addition to standard chemoradiotherapy and adjuvant temozolomide in patients with…”
Get full text

Unblocking the cancer drug development bottleneck via innovative partnering by Ritchie, James WA, Jones, Hazel, Williams, Robert J

“…The CDD currently consists of a team of around 80 scientific and clinical operations staff that manages a portfolio of approximately 25 active drug development…”
Get full text

Cancer Research UK Centre for Drug Development: translating 21st-century science into the cancer medicines of tomorrow by Ritchie, James W.A., Williams, Robert J.

“…•CRUK Centre for Drug Development is a non-commercial cancer drug development resource.•It provides a unique route for development of academic and commercial…”
Get full text

Tissue uptake of thyroid hormone by amino acid transporters by Taylor, Peter M, Ritchie, James W.A

“…Thyroid hormones (THs) – thyroxine (T4 ) and tri-iodothyronine (T3 ) – are iodinated derivatives of the amino acid tyrosine, which regulates growth,…”
Get full text

Role of the System L permease LAT1 in amino acid and iodothyronine transport in placenta by RITCHIE, James W. A., TAYLOR, Peter M.

“…The feto-placental unit relies on a maternal supply of indispensable amino acids and iodothyronines for early development and normal growth. We examined the…”
Get full text

Effect of hypothyroidism on pathways for iodothyronine and tryptophan uptake into rat adipocytes by Ritchie, J W, Collingwood, C J, Taylor, P M

“…Adipocytes are an important target tissue for thyroid hormone action, but little is known of the mechanisms of thyroid hormone entry into the cells. The…”
Get more information

Complex regulation of thyroid hormone action: multiple opportunities for pharmacological intervention by Shi, Yun-Bo, Ritchie, James W.A., Taylor, Peter M.

“…The thyroid hormone (TH; 3,3′,5,5′-tetra-iodothyronine and 3,3′,5′-triiodothyronine) regulates growth, development, and critical metabolic functions. Thyroid…”
Get full text