Search Results - "Ritchie, D. M."

Optimizing Drug Outcomes Through Pharmacogenetics: A Case for Preemptive Genotyping by Schildcrout, J S, Denny, J C, Bowton, E, Gregg, W, Pulley, J M, Basford, M A, Cowan, J D, Xu, H, Ramirez, A H, Crawford, D C, Ritchie, M D, Peterson, J F, Masys, D R, Wilke, R A, Roden, D M

“…Routine integration of genotype data into drug decision making could improve patient safety, particularly if many relevant genetic variants can be assayed…”
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Predicting Clopidogrel Response Using DNA Samples Linked to an Electronic Health Record by Delaney, J T, Ramirez, A H, Bowton, E, Pulley, J M, Basford, M A, Schildcrout, J S, Shi, Y, Zink, R, Oetjens, M, Xu, H, Cleator, J H, Jahangir, E, Ritchie, M D, Masys, D R, Roden, D M, Crawford, D C, Denny, J C

“…Variants in ABCB1 and CYP2C19 have been identified as predictors of cardiac events during clopidogrel therapy initiated after myocardial infarction (MI) or…”
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Opportunities and challenges for biomarker discovery using electronic health record data by Singhal, P., Tan, A.L.M., Drivas, T.G., Johnson, K.B., Ritchie, M.D., Beaulieu-Jones, B.K.

“…Electronic health records (EHRs) have become increasingly relied upon as a source for biomedical research.Many different data types are available in EHR,…”
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Genetic variation among 82 pharmacogenes: The PGRNseq data from the eMERGE network by Bush, WS, Crosslin, DR, Owusu-Obeng, A, Wallace, J, Almoguera, B, Basford, MA, Bielinski, SJ, Carrell, DS, Connolly, JJ, Crawford, D, Doheny, KF, Gallego, CJ, Gordon, AS, Keating, B, Kirby, J, Kitchner, T, Manzi, S, Mejia, AR, Pan, V, Perry, CL, Peterson, JF, Prows, CA, Ralston, J, Scott, SA, Scrol, A, Smith, M, Stallings, SC, Veldhuizen, T, Wolf, W, Volpi, S, Wiley, K, Li, R, Manolio, T, Bottinger, E, Brilliant, MH, Carey, D, Chisholm, RL, Chute, CG, Haines, JL, Hakonarson, H, Harley, JB, Holm, IA, Kullo, IJ, Jarvik, GP, Larson, EB, McCarty, CA, Williams, MS, Denny, JC, Rasmussen-Torvik, LJ, Roden, DM, Ritchie, MD

“…Genetic variation can affect drug response in multiple ways, although it remains unclear how rare genetic variants affect drug response. The electronic Medical…”
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Multifactor-dimensionality reduction shows a two-locus interaction associated with Type 2 diabetes mellitus by CHO, Y. M, RITCHIE, M. D, MOORE, J. H, PARK, J. Y, LEE, K.-U, SHIN, H. D, LEE, H. K, PARK, K. S

“…Type 2 diabetes mellitus is a complex genetic disease, which results from interactions between multiple genes and environmental factors without any single…”
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A novel method to identify gene-gene effects in nuclear families: the MDR-PDT by Martin, E.R., Ritchie, M.D., Hahn, L., Kang, S., Moore, J.H.

“…It is now well recognized that gene–gene and gene–environment interactions are important in complex diseases, and statistical methods to detect interactions…”
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Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance) by Chhibber, A, Mefford, J, Stahl, E A, Pendergrass, S A, Baldwin, R M, Owzar, K, Li, M, Winer, E P, Hudis, C A, Zembutsu, H, Kubo, M, Nakamura, Y, McLeod, H L, Ratain, M J, Shulman, L N, Ritchie, M D, Plenge, R M, Witte, J S, Kroetz, D L

“…Peripheral neuropathy is a common dose-limiting toxicity for patients treated with paclitaxel. For most individuals, there are no known risk factors that…”
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Identification of Significant Association and Gene-Gene Interaction of GABA Receptor Subunit Genes in Autism by Ma, D.Q., Whitehead, P.L., Menold, M.M., Martin, E.R., Ashley-Koch, A.E., Mei, H., Ritchie, M.D., DeLong, G.R., Abramson, R.K., Wright, H.H., Cuccaro, M.L., Hussman, J.P., Gilbert, J.R., Pericak-Vance, M.A.

“…Autism is a common neurodevelopmental disorder with a significant genetic component. Existing research suggests that multiple genes contribute to autism and…”
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Drug Transporter and Metabolizing Enzyme Gene Variants and Nonnucleoside Reverse-Transcriptase Inhibitor Hepatotoxicity by Ritchie, Marylyn D., Haas, David W., Motsinger, Alison A., Donahue, John P., Erdem, Huso, Raffanti, Stephen, Rebeiro, Peter, George, Alfred L., Kim, Richard B., Haines, Jonathan L., Sterling, Timothy R.

“…This nested case-control study examined relationships between MDR1, CYP2B6, and CYP3A4 variants and hepatotoxicity during antiretroviral therapy with either…”
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Design and Anticipated Outcomes of the eMERGE-PGx Project: A Multicenter Pilot for Preemptive Pharmacogenomics in Electronic Health Record Systems by Rasmussen-Torvik, L J, Stallings, S C, Gordon, A S, Almoguera, B, Basford, M A, Bielinski, S J, Brautbar, A, Brilliant, M H, Carrell, D S, Connolly, J J, Crosslin, D R, Doheny, K F, Gallego, C J, Gottesman, O, Kim, D S, Leppig, K A, Li, R, Lin, S, Manzi, S, Mejia, A R, Pacheco, J A, Pan, V, Pathak, J, Perry, C L, Peterson, J F, Prows, C A, Ralston, J, Rasmussen, L V, Ritchie, M D, Sadhasivam, S, Scott, S A, Smith, M, Vega, A, Vinks, A A, Volpi, S, Wolf, W A, Bottinger, E, Chisholm, R L, Chute, C G, Haines, J L, Harley, J B, Keating, B, Holm, I A, Kullo, I J, Jarvik, G P, Larson, E B, Manolio, T, McCarty, C A, Nickerson, D A, Scherer, S E, Williams, M S, Roden, D M, Denny, J C

“…We describe here the design and initial implementation of the eMERGE‐PGx project. eMERGE‐PGx, a partnership of the Electronic Medical Records and Genomics…”
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The mitochondrial pharmacogenomics of haplogroup T: MTND2LHON4917G and antiretroviral therapy-associated peripheral neuropathy by Canter, J A, Haas, D W, Kallianpur, A R, Ritchie, M D, Robbins, G K, Shafer, R W, Clifford, D B, Murdock, D G, Hulgan, T

“…Peripheral neuropathy (PN) due to mitochondrial injury complicates HIV therapy with some nucleoside reverse transcriptase inhibitors (NRTIs). Variation in the…”
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tAnGo: a randomised phase III trial of gemcitabine in paclitaxel-containing, epirubicin/cyclophosphamide-based, adjuvant chemotherapy for early breast cancer: a prospective pulmonary, cardiac and hepatic function evaluation by Wardley, A M, Hiller, L, Howard, H C, Dunn, J A, Bowman, A, Coleman, R E, Fernando, I N, Ritchie, D M, Earl, H M, Poole, C J

“…tAnGo is a large randomised trial assessing the addition of gemcitabine(G) to paclitaxel(T), following epirubicin(E) and cyclophosphamide(C) in women with…”
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The Bradykinin Type 2 Receptor BE1 Polymorphism and Ethnicity Influence Systolic Blood Pressure and Vascular Resistance by Pretorius, M M, Gainer, J V, Van Guilder, G P, Coelho, E B, Luther, J M, Fong, P, Rosenbaum, D D, Malave, H A, Yu, C, Ritchie, M D, Vaughan, D E, Brown, N J

“…We examined the effect of −58 C/T and BE1 +9/−9 polymorphisms in the bradykinin B2 receptor gene on forearm vascular resistance (FVR) before and during…”
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Multifactor dimensionality reduction reveals gene-gene interactions associated with multiple sclerosis susceptibility in African Americans by Brassat, D, Motsinger, A A, Caillier, S J, Erlich, H A, Walker, K, Steiner, L L, Cree, B A C, Barcellos, L F, Pericak-Vance, M A, Schmidt, S, Gregory, S, Hauser, S L, Haines, J L, Oksenberg, J R, Ritchie, M D

“…Multiple sclerosis (MS) is a common disease of the central nervous system characterized by inflammation, myelin loss, gliosis, varying degrees of axonal…”
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An analysis paradigm for investigating multi-locus effects in complex disease: examination of three GABA receptor subunit genes on 15q11-q13 as risk factors for autistic disorder by Ashley-Koch, A E, Mei, H, Jaworski, J, Ma, D Q, Ritchie, M D, Menold, M M, Delong, G R, Abramson, R K, Wright, H H, Hussman, J P, Cuccaro, M L, Gilbert, J R, Martin, E R, Pericak-Vance, M A

“…Gene-gene interactions are likely involved in many complex genetic disorders and new statistical approaches for detecting such interactions are needed. We…”
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The use of phenome-wide association studies (PheWAS) for exploration of novel genotype-phenotype relationships and pleiotropy discovery by Pendergrass, S.A., Brown-Gentry, K., Dudek, S.M., Torstenson, E.S., Ambite, J.L., Avery, C.L., Buyske, S., Cai, C., Fesinmeyer, M.D., Haiman, C., Heiss, G., Hindorff, L.A., Hsu, C.-N., Jackson, R.D., Kooperberg, C., Le Marchand, L., Lin, Y., Matise, T.C., Moreland, L., Monroe, K., Reiner, A.P., Wallace, R., Wilkens, L.R., Crawford, D.C., Ritchie, M.D.

“…The field of phenomics has been investigating network structure among large arrays of phenotypes, and genome‐wide association studies (GWAS) have been used to…”
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A genome-wide association study identifies variants in KCNIP4 associated with ACE inhibitor-induced cough by Mosley, J D, Shaffer, C M, Van Driest, S L, Weeke, P E, Wells, Q S, Karnes, J H, Velez Edwards, D R, Wei, W-Q, Teixeira, P L, Bastarache, L, Crawford, D C, Li, R, Manolio, T A, Bottinger, E P, McCarty, C A, Linneman, J G, Brilliant, M H, Pacheco, J A, Thompson, W, Chisholm, R L, Jarvik, G P, Crosslin, D R, Carrell, D S, Baldwin, E, Ralston, J, Larson, E B, Grafton, J, Scrol, A, Jouni, H, Kullo, I J, Tromp, G, Borthwick, K M, Kuivaniemi, H, Carey, D J, Ritchie, M D, Bradford, Y, Verma, S S, Chute, C G, Veluchamy, A, Siddiqui, M K, Palmer, C N A, Doney, A, MahmoudPour, S H, Maitland-van der Zee, A H, Morris, A D, Denny, J C, Roden, D M

“…The most common side effect of angiotensin-converting enzyme inhibitor (ACEi) drugs is cough. We conducted a genome-wide association study (GWAS) of…”
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Genetic variation in the HLA region is associated with susceptibility to herpes zoster by Crosslin, D R, Carrell, D S, Burt, A, Kim, D S, Underwood, J G, Hanna, D S, Comstock, B A, Baldwin, E, de Andrade, M, Kullo, I J, Tromp, G, Kuivaniemi, H, Borthwick, K M, McCarty, C A, Peissig, P L, Doheny, K F, Pugh, E, Kho, A, Pacheco, J, Hayes, M G, Ritchie, M D, Verma, S S, Armstrong, G, Stallings, S, Denny, J C, Carroll, R J, Crawford, D C, Crane, P K, Mukherjee, S, Bottinger, E, Li, R, Keating, B, Mirel, D B, Carlson, C S, Harley, J B, Larson, E B, Jarvik, G P

“…Herpes zoster, commonly referred to as shingles, is caused by the varicella zoster virus (VZV). VZV initially manifests as chicken pox, most commonly in…”
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Generalization and fine mapping of European ancestry-based central adiposity variants in African ancestry populations by Yoneyama, S, Yao, J, Guo, X, Fernandez-Rhodes, L, Lim, U, Boston, J, Buzková, P, Carlson, C S, Cheng, I, Cochran, B, Cooper, R, Ehret, G, Fornage, M, Gong, J, Gross, M, Gu, C C, Haessler, J, Haiman, C A, Henderson, B, Hindorff, L A, Houston, D, Irvin, M R, Jackson, R, Kuller, L, Leppert, M, Lewis, C E, Li, R, Le Marchand, L, Matise, T C, Nguyen, K-DH, Chakravarti, A, Pankow, J S, Pankratz, N, Pooler, L, Ritchie, M D, Bien, S A, Wassel, C L, Chen, Y-DI, Taylor, K D, Allison, M, Rotter, J I, Schreiner, P J, Schumacher, F, Wilkens, L, Boerwinkle, E, Kooperberg, C, Peters, U, Buyske, S, Graff, M, North, K E

“…Background/Objectives: Central adiposity measures such as waist circumference (WC) and waist-to-hip ratio (WHR) are associated with cardiometabolic disorders…”
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1,3-Diarylcycloalkanopyrazoles and diphenyl hydrazides as selective inhibitors of cyclooxygenase-2 by ZHIHUA SUI, JIHUA GUAN, FERRO, M. P, MCCOY, K, WACHTER, M. P, MURRAY, W. V, SINGER, M, STEBER, M, RITCHIE, D. M, ARGENTIERI, D. C

“…Novel 1,3-diarylcycloalkanopyrazoles 1, and diphenyl hydrazides 2 were identified as selective inhibitors of cyclooxygenase-2. The 1,3-diaryl substitution…”
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