Search Results - "Risso, A"

Conformational dynamics and enzyme evolution by Petrović, Dušan, Risso, Valeria A, Kamerlin, Shina Caroline Lynn, Sanchez-Ruiz, Jose M

“…Enzymes are dynamic entities, and their dynamic properties are clearly linked to their biological function. It follows that dynamics ought to play an essential…”
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Biotechnological and protein-engineering implications of ancestral protein resurrection by Risso, Valeria A, Sanchez-Ruiz, Jose M, Ozkan, S Banu

“…•Ancestral environments likely differed from the environments hosting modern proteins.•Resurrected ancestral protein often display unusual properties and…”
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Cooperativity and flexibility in enzyme evolution by Pabis, Anna, Risso, Valeria A, Sanchez-Ruiz, Jose M, Kamerlin, Shina CL

“…[Display omitted] •Cooperativity and flexibility play important roles in enzyme evolution.•Evolutionarily-important flexibility can be both structural or…”
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Hinge-shift mechanism as a protein design principle for the evolution of β-lactamases from substrate promiscuity to specificity by Modi, Tushar, Risso, Valeria A., Martinez-Rodriguez, Sergio, Gavira, Jose A., Mebrat, Mubark D., Van Horn, Wade D., Sanchez-Ruiz, Jose M., Banu Ozkan, S.

“…TEM-1 β-lactamase degrades β-lactam antibiotics with a strong preference for penicillins. Sequence reconstruction studies indicate that it evolved from…”
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Manipulating Conformational Dynamics To Repurpose Ancient Proteins for Modern Catalytic Functions by Gardner, Jasmine M, Biler, Michal, Risso, Valeria A, Sanchez-Ruiz, Jose M, Kamerlin, Shina C. L

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Prevalence and associated factors of adverse childhood experiences (ACE) in a sample of Brazilian university students by Risso, Patrícia A., Jural, Lucas A., Santos, Ismê C., Cunha, Antonio J.L.A.

“…Adverse childhood experiences (ACEs) have long been associated with health risk behaviors, but they are poorly studied in Brazilian university students. To…”
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Traumatic dental injuries and their sequelae in visually impaired adolescents by Dode, Carolina Borio, Cavalcante, Yuri, Risso, Patrícia A.

“…Background/Aim Traumatic dental injuries are a public health problem. Visual impairment can be considered a risk factor for traumatic dental injury given the…”
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Evolution of conformational dynamics determines the conversion of a promiscuous generalist into a specialist enzyme by Zou, Taisong, Risso, Valeria A, Gavira, Jose A, Sanchez-Ruiz, Jose M, Ozkan, S Banu

“…β-Lactamases are produced by many modern bacteria as a mechanism of resistance toward β-lactam antibiotics, the most common antibiotics in use. β-Lactamases,…”
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Efficient Base-Catalyzed Kemp Elimination in an Engineered Ancestral Enzyme by Gutierrez-Rus, Luis I, Alcalde, Miguel, Risso, Valeria A, Sanchez-Ruiz, Jose M

“…The routine generation of enzymes with completely new active sites is a major unsolved problem in protein engineering. Advances in this field have thus far…”
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De novo active sites for resurrected Precambrian enzymes by Risso, Valeria A., Martinez-Rodriguez, Sergio, Candel, Adela M., Krüger, Dennis M., Pantoja-Uceda, David, Ortega-Muñoz, Mariano, Santoyo-Gonzalez, Francisco, Gaucher, Eric A., Kamerlin, Shina C. L., Bruix, Marta, Gavira, Jose A., Sanchez-Ruiz, Jose M.

“…Protein engineering studies often suggest the emergence of completely new enzyme functionalities to be highly improbable. However, enzymes likely catalysed…”
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Modeling of dynamic behavior of a single-point moored submersible fish cage under currents by DeCew, J., Tsukrov, I., Risso, A., Swift, M.R., Celikkol, B.

“…The submergence behavior of a small volume fish cage in a single-point mooring system under currents is investigated using a numerical model. Results are…”
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Correction for Gomez-Fernandez et al., “Ancestral Resurrection and Directed Evolution of Fungal Mesozoic Laccases” by Gomez-Fernandez, Bernardo J., Risso, Valeria A., Rueda, Andres, Sanchez-Ruiz, Jose M., Alcalde, Miguel

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Dental caries in the permanent dentition and health-related quality of life among children and adolescents with sickle cell disease by Mendes, Vera Lúcia Duarte da Costa, Risso, Patrícia A, Santos, Marcia Pereira Alves Dos

“…The aim was to associate living, health and oral health conditions with the quality of life (QL) of children and adolescents (CA) with sickle cell disease…”
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Heme-binding enables allosteric modulation in an ancient TIM-barrel glycosidase by Gamiz-Arco, Gloria, Gutierrez-Rus, Luis I., Risso, Valeria A., Ibarra-Molero, Beatriz, Hoshino, Yosuke, Petrović, Dušan, Justicia, Jose, Cuerva, Juan Manuel, Romero-Rivera, Adrian, Seelig, Burckhard, Gavira, Jose A., Kamerlin, Shina C. L., Gaucher, Eric A., Sanchez-Ruiz, Jose M.

“…Glycosidases are phylogenetically widely distributed enzymes that are crucial for the cleavage of glycosidic bonds. Here, we present the exceptional properties…”
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YouTube™ as a source of tooth avulsion information: A video analysis study by Loureiro, Jéssica Muniz, Chaves, Victor Carvalho Vitolo, Risso, Patrícia A., Magno, Marcela Baraúna, Maia, Lucianne Cople, Pithon, Matheus de Melo

“…Abstract Background/Aim Evaluate the informative content in tooth avulsion videos intended for dentists available on YouTube™ and analyse their compliance with…”
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World trends in publication for maxillofacial and dental trauma in the elderly by Turino, Fabiana Dantas, Jural, Lucas Alves, Silva, Leticia Lopes A., Magno, Marcela Baraúna, Maia, Luciane Cople, Risso, Patrícia A.

“…Aging may increase the risk of maxillofacial and dentoalveolar trauma (MDT). This review assessed global trends in scientific publications on MDT in the…”
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Phenotypic comparisons of consensus variants versus laboratory resurrections of Precambrian proteins by Risso, Valeria A., Gavira, Jose A., Gaucher, Eric A., Sanchez-Ruiz, Jose M.

“…ABSTRACT Consensus‐sequence engineering has generated protein variants with enhanced stability, and sometimes, with modulated biological function. Consensus…”
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Intermittent high glucose enhances apoptosis in human umbilical vein endothelial cells in culture by Risso, A, Mercuri, F, Quagliaro, L, Damante, G, Ceriello, A

“…To explore the effect of fluctuating glucose on endothelial cells, human umbilical vein endothelial cells were incubated for 14 days in media containing…”
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Critical appraisal of the information available on traumatic dental injuries found in applications by Loureiro, Jéssica Muniz, Jural, Lucas Alves, Soares, Thais Rodrigues Campos, Risso, Patrícia A., Fonseca‐Gonçalves, Andréa, Magno, Marcela Baraúna, Maia, Lucianne Cople

“…Background/Aims Traumatic dental injuries (TDI) are a public health problem and the search for information becomes essential to help in their management. The…”
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Consensus Design of an Evolved High-Redox Potential Laccase by Gomez-Fernandez, Bernardo J, Risso, Valeria A, Sanchez-Ruiz, Jose M, Alcalde, Miguel

“…Among the broad repertory of protein engineering methods that set out to improve stability, consensus design has proved to be a powerful strategy to stabilize…”
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