Search Results - "Risler, Thomas"

Focus on the physics of cancer by Risler, Thomas

“…Despite the spectacular achievements of molecular biology in the second half of the twentieth century and the crucial advances it permitted in cancer research,…”
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Viscocapillary instability in cellular spheroids by Martin, Matthieu, Risler, Thomas

“…Abstract We describe a viscocapillary instability that can perturb the spherical symmetry of cellular aggregates in culture, also called multicellular…”
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Morphological instabilities of stratified epithelia: a mechanical instability in tumour formation by Risler, Thomas, Basan, Markus

“…Interfaces between stratified epithelia and their supporting stromas commonly exhibit irregular shapes. Undulations are particularly pronounced in dysplastic…”
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Coherent motion of stereocilia assures the concerted gating of hair-cell transduction channels by Hudspeth, A J, Risler, Thomas, Kozlov, Andrei S

“…The hair cell's mechanoreceptive organelle, the hair bundle, is highly sensitive because its transduction channels open over a very narrow range of…”
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The Development of Cooperative Channels Explains the Maturation of Hair Cell'S Mechanotransduction by Gianoli, Francesco, Risler, Thomas, Kozlov, Andrei S.

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Tension-oriented cell divisions limit anisotropic tissue tension in epithelial spreading during zebrafish epiboly by Campinho, Pedro, Behrndt, Martin, Ranft, Jonas, Risler, Thomas, Minc, Nicolas, Heisenberg, Carl-Philipp

“…Epithelial spreading is a common and fundamental aspect of various developmental and disease-related processes such as epithelial closure and wound healing. A…”
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The Development of Cooperative Channels Explains the Maturation of Hair Cell’s Mechanotransduction by Gianoli, Francesco, Risler, Thomas, Kozlov, Andrei S.

“…Hearing relies on the conversion of mechanical stimuli into electrical signals. In vertebrates, this process of mechanoelectrical transduction (MET) is…”
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Homeostatic competition drives tumor growth and metastasis nucleation by Basan, Markus, Risler, Thomas, Joanny, Jean-François, Sastre-Garau, Xavier, Prost, Jacques

“…We propose a mechanism for tumor growth emphasizing the role of homeostatic regulation and tissue stability. We show that competition between surface and bulk…”
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Homeostatic Fluctuations of a Tissue Surface by Risler, Thomas, Peilloux, Aurélien, Prost, Jacques

“…We study the surface fluctuations of a tissue with a dynamics dictated by cell-rearrangement, cell-division, and cell-death processes. Surface fluctuations are…”
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Lipid bilayer mediates ion-channel cooperativity in a model of hair-cell mechanotransduction by Gianoli, Francesco, Risler, Thomas, Kozlov, Andrei S.

“…Mechanoelectrical transduction in the inner ear is a biophysical process underlying the senses of hearing and balance. The key players involved in this process…”
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Fast adaptation of cooperative channels engenders Hopf bifurcations in auditory hair cells by Gianoli, Francesco, Hogan, Brenna, Dilly, Émilien, Risler, Thomas, Kozlov, Andrei S.

“…Since the pioneering work of Thomas Gold, published in 1948, it has been known that we owe our sensitive sense of hearing to a process in the inner ear that…”
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Spontaneous flow created by active topological defects by Brézin, Louis, Risler, Thomas, Joanny, Jean-Francois

“…Topological defects are at the root of the large-scale organization of liquid crystals. In two-dimensional active nematics, two classes of topological defects…”
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Stress clamp experiments on multicellular tumor spheroids by Montel, Fabien, Delarue, Morgan, Elgeti, Jens, Malaquin, Laurent, Basan, Markus, Risler, Thomas, Cabane, Bernard, Vignjevic, Danijela, Prost, Jacques, Cappello, Giovanni, Joanny, Jean-François

“…The precise role of the microenvironment on tumor growth is poorly understood. Whereas the tumor is in constant competition with the surrounding tissue, little…”
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Forces drive basement membrane invasion in Caenorhabditis elegans by Cáceres, Rodrigo, Bojanala, Nagagireesh, Kelley, Laura C., Dreier, Jes, Manzi, John, Di Federico, Fahima, Chi, Qiuyi, Risler, Thomas, Testa, Ilaria, Sherwood, David R., Plastino, Julie

“…During invasion, cells breach basement membrane (BM) barriers with actin-rich protrusions. It remains unclear, however, whether actin polymerization applies…”
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Crisscross multilayering of cell sheets by Sarkar, Trinish, Yashunsky, Victor, Brézin, Louis, Blanch Mercader, Carles, Aryaksama, Thibault, Lacroix, Mathilde, Risler, Thomas, Joanny, Jean-François, Silberzan, Pascal

“…Hydrostatic skeletons such as the Hydra's consist of two stacked layers of muscle cells perpendicularly oriented. In vivo, these bilayers first assemble, and…”
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Forces between clustered stereocilia minimize friction in the ear on a subnanometre scale by Kozlov, Andrei S., Baumgart, Johannes, Risler, Thomas, Versteegh, Corstiaen P. C., Hudspeth, A. J.

“…How inner-ear stereocilia pull together Hearing is initiated by the movement of tiny bundles of cilia located at the top of hair cells inside the ear. Despite…”
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Undulation instability of epithelial tissues by Basan, Markus, Joanny, Jean-François, Prost, Jacques, Risler, Thomas

“…Treating the epithelium as an incompressible fluid adjacent to a viscoelastic stroma, we find a novel hydrodynamic instability that leads to the formation of…”
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A Reaction-Diffusion Model of the Cadherin-Catenin System: A Possible Mechanism for Contact Inhibition and Implications for Tumorigenesis by Basan, Markus, Idema, Timon, Lenz, Martin, Joanny, Jean-François, Risler, Thomas

“…Contact inhibition is the process by which cells switch from a motile growing state to a passive and stabilized state upon touching their neighbors. When two…”
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Viscocapillary Instability in Cellular Spheroids by Martin, Matthieu, Risler, Thomas

“…New J. Phys. 23 033032 (2021) We describe a viscocapillary instability that can perturb the spherical symmetry of cellular aggregates in culture, also called…”
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Relative stereociliary motion in a hair bundle opposes amplification at distortion frequencies by Kozlov, Andrei S., Risler, Thomas, Hinterwirth, Armin J., Hudspeth, A.J.

“…Non‐technical summary  The hair cell, or sensory receptor of the inner ear, achieves high sensitivity by amplifying its mechanical inputs. The mechanism of…”
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