Search Results - "Risede, Patricia"

Mechanisms of respiratory depression induced by the combination of buprenorphine and diazepam in rats by Vodovar, Dominique, Chevillard, Lucie, Caillé, Fabien, Risède, Patricia, Pottier, Géraldine, Auvity, Sylvain, Mégarbane, Bruno, Tournier, Nicolas

“…The safety profile of buprenorphine has encouraged its widespread use. However, fatalities have been attributed to benzodiazepine/buprenorphine combinations,…”
Get more information

Is naloxone the best antidote to reverse tramadol-induced neuro-respiratory toxicity in overdose? An experimental investigation in the rat by Lagard, Camille, Malissin, Isabelle, Indja, Wassila, Risède, Patricia, Chevillard, Lucie, Mégarbane, Bruno

“…Context: Since the banning of dextropropoxyphene from the market, overdoses, and fatalities attributed to tramadol, a WHO step-2 opioid analgesic, have…”
Get full text

Mechanisms of tramadol-related neurotoxicity in the rat: Does diazepam/tramadol combination play a worsening role in overdose? by Lagard, Camille, Chevillard, Lucie, Malissin, Isabelle, Risède, Patricia, Callebert, Jacques, Labat, Laurence, Launay, Jean-Marie, Laplanche, Jean-Louis, Mégarbane, Bruno

“…Poisoning with opioid analgesics including tramadol represents a challenge. Tramadol may induce respiratory depression, seizures and serotonin syndrome,…”
Get full text

Does lithium poisoning induce brain injuries?—A histopathological rat study by Klein, Mathieu, Naffaa, Vanessa, Chevillard, Lucie, Risède, Patricia, Saubaméa, Bruno, Adle‐Biassette, Homa, Mégarbane, Bruno

“…Due to a narrow therapeutic index, prolonged lithium treatment and overdose may result in neurotoxicity. Neurotoxicity is deemed reversible with lithium…”
Get full text

Study of blood and brain lithium pharmacokinetics in the rat according to three different modalities of poisoning by Hanak, Anne-Sophie, Chevillard, Lucie, El Balkhi, Souleiman, Risède, Patricia, Peoc'h, Katell, Mégarbane, Bruno

“…Lithium-induced neurotoxicity may be life threatening. Three patterns have been described, including acute, acute-on-chronic, and chronic poisoning, with…”
Get full text

Baclofen-Induced Neuro-Respiratory Toxicity in the Rat: Contribution of Tolerance and Characterization of Withdrawal Syndrome by Chartier, Magali, Tannous, Salma, Benturquia, Nadia, Labat, Laurence, Reis, Rafael, Risède, Patricia, Chevillard, Lucie, Mégarbane, Bruno

“…Abstract Baclofen, a γ-amino-butyric acid type-B receptor agonist with exponentially increased use at high-dose to facilitate abstinence in chronic alcoholics,…”
Get full text

Baclofen-induced encephalopathy in overdose – Modeling of the electroencephalographic effect/concentration relationships and contribution of tolerance in the rat by Chartier, Magali, Malissin, Isabelle, Tannous, Salma, Labat, Laurence, Risède, Patricia, Mégarbane, Bruno, Chevillard, Lucie

“…Baclofen, a γ-amino-butyric acid type-B receptor agonist with exponentially increased use at high-dose to facilitate abstinence in chronic alcoholics, is…”
Get full text

Investigation of the Mechanisms of Tramadol-Induced Seizures in Overdose in the Rat by Lagard, Camille, Vodovar, Dominique, Chevillard, Lucie, Callebert, Jacques, Caillé, Fabien, Pottier, Géraldine, Liang, Hao, Risède, Patricia, Tournier, Nicolas, Mégarbane, Bruno

“…Tramadol overdose is frequently associated with the onset of seizures, usually considered as serotonin syndrome manifestations. Recently, the serotoninergic…”
Get full text

Respiratory effects of buprenorphine/naloxone alone and in combination with diazepam in naive and tolerant rats by Cohier, Camille, Chevillard, Lucie, Risède, Patricia, Roussel, Olivier, Mégarbane, Bruno

“…•Like buprenorphine alone, buprenorphine/naloxone does not depress ventilation in rats.•IV buprenorphine/naloxone injection induces withdrawal symptoms in…”
Get full text

Neurobehavioral effects of lithium in the rat: Investigation of the effect/concentration relationships and the contribution of the poisoning pattern by Hanak, Anne-Sophie, Chevillard, Lucie, Lebeau, Rodolphe, Risède, Patricia, Laplanche, Jean-Louis, Benturquia, Nadia, Mégarbane, Bruno

“…Severity of lithium poisoning depends on the ingested dose, previous treatment duration and renal function. No animal study has investigated neurobehavioral…”
Get full text

Bifunctional peptide-based opioid agonist/nociceptin antagonist ligand for dual treatment of nociceptive and neuropathic pain by Lagard, Camille, Chevillard, Lucie, Guillemyn, Karel, Risède, Patricia, Laplanche, Jean-Louis, Spetea, Mariana, Ballet, Steven, Mégarbane, Bruno

“…Drugs able to treat both nociceptive and neuropathic pain effectively without major side effects are lacking. We developed a bifunctional peptide-based hybrid…”
Get full text

Electroencephalographic patterns of lithium poisoning: a study of the effect/concentration relationships in the rat by Hanak, Anne‐Sophie, Malissin, Isabelle, Poupon, Joël, Risède, Patricia, Chevillard, Lucie, Mégarbane, Bruno

“…Objectives Lithium overdose may result in encephalopathy and electroencephalographic abnormalities. Three poisoning patterns have been identified based on the…”
Get full text

Investigation of lithium distribution in the rat brain ex vivo using lithium‐7 magnetic resonance spectroscopy and imaging at 17.2 T by Stout, Jacques, Hanak, Anne‐Sophie, Chevillard, Lucie, Djemaï, Boucif, Risède, Patricia, Giacomini, Eric, Poupon, Joël, Barrière, David André, Bellivier, Frank, Mégarbane, Bruno, Boumezbeur, Fawzi

“…Lithium is the first‐line mood stabilizer for the treatment of patients with bipolar disorder. However, its mechanisms of action and transport across the…”
Get full text

Respiratory toxicity of buprenorphine results from the blockage of P-glycoprotein-mediated efflux of norbuprenorphine at the blood–brain barrier in mice by Alhaddad, Hisham, Cisternino, Salvatore, Declèves, Xavier, Tournier, Nicolas, Schlatter, Joel, Chiadmi, Fouad, Risède, Patricia, Smirnova, Maria, Besengez, Capucine, Scherrmann, Jean-Michel, Baud, Frédéric J, Mégarbane, Bruno

“…OBJECTIVES:Deaths due to asphyxia as well as following acute poisoning with severe respiratory depression have been attributed to buprenorphine in opioid…”
Get full text

Respiratory effects of diazepam/methadone combination in rats: A study based on concentration/effect relationships by Chevillard, Lucie, Declèves, Xavier, Baud, Frédéric J, Risède, Patricia, Mégarbane, Bruno

“…Abstract Background Methadone may cause respiratory depression and fatalities. Concomitant use of benzodiazepines in methadone-treated patients for chronic…”
Get full text

Comparison of tolerance to morphine-induced respiratory and analgesic effects in mice by Mohammed, Wasseem, Alhaddad, Hisham, Marie, Nicolas, Tardy, Floriane, Lamballais, Florence, Risède, Patricia, Noble, Florence, Baud, Frédéric J., Mégarbane, Bruno

“…► An analgesic dose of morphine induces a significant increase in inspiratory time. ► Tolerance to morphine-related respiratory effects is more limited than to…”
Get full text

Characteristics and comparative severity of respiratory response to toxic doses of fentanyl, methadone, morphine, and buprenorphine in rats by Chevillard, Lucie, Mégarbane, Bruno, Risède, Patricia, Baud, Frédéric J.

“…Opioids are known to induce respiratory depression. We aimed to characterize in rats the effects of four opioids on arterial blood gases and plethysmography…”
Get full text

Pharmacokinetics and Toxicodynamics of Pralidoxime Effects on Paraoxon-Induced Respiratory Toxicity by Houzé, Pascal, Mager, Donald E., Risède, Patricia, Baud, Frédéric J.

“…Empirical studies suggest that the antidotal effect of pralidoxime depends on plasma concentrations with therapeutic effects associated with concentrations…”
Get full text

Mechanisms of high-dose citalopram-induced death in a rat model by Beaune, Sébastien, Callebert, Jacques, Baud, Frédéric J, Risède, Patricia, Juvin, Philippe, Mégarbane, Bruno

“…Highlights ► The median lethal dose of intraperitoneal citalopram is 102 mg/kg. ► Key-features to explain citalopram-induced death are serotonin syndrome and…”
Get full text

Gender and strain contributions to the variability of buprenorphine-related respiratory toxicity in mice by Alhaddad, Hisham, Cisternino, Salvatore, Saubamea, Bruno, Schlatter, Joel, Chiadmi, Fouad, Risède, Patricia, Smirnova, Maria, Cochois-Guégan, Véronique, Tournier, Nicolas, Baud, Frédéric J, Mégarbane, Bruno

“…Abstract While most deaths from asphyxia related to buprenorphine (BUP) overdose have been reported in males, higher plasma concentrations of BUP and its toxic…”
Get full text