Search Results - "Rischer, Heiko"

The killer of Socrates: Coniine and Related Alkaloids in the Plant Kingdom by Hotti, Hannu, Rischer, Heiko

“…Coniine, a polyketide-derived alkaloid, is poisonous to humans and animals. It is a nicotinic acetylcholine receptor antagonist, which leads to inhibition of…”
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Euglena gracilis growth and cell composition under different temperature, light and trophic conditions by Wang, Yanming, Seppänen-Laakso, Tuulikki, Rischer, Heiko, Wiebe, Marilyn G

“…Euglena gracilis, a photosynthetic protist, produces protein, unsaturated fatty acids, wax esters, and a unique β-1,3-glucan called paramylon, along with other…”
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bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus by Van Moerkercke, Alex, Priscille Steensma, Fabian Schweizer, Jacob Pollier, Ivo Gariboldi, Richard Payne, Robin Vanden Bossche, Karel Miettinen, Javiera Espoz, Purin Candra Purnama, Franziska Kellner, Tuulikki Seppänen-Laakso, Sarah E. O’Connor, Heiko Rischer, Johan Memelink, Alain Goossens

“…Plants make specialized bioactive metabolites to defend themselves against attackers. The conserved control mechanisms are based on transcriptional activation…”
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De novo transcriptome assembly of Conium maculatum L. to identify candidate genes for coniine biosynthesis by Peddinti, Gopal, Hotti, Hannu, Teeri, Teemu H., Rischer, Heiko

“…Poison hemlock ( Conium maculatum L.) is a notorious weed containing the potent alkaloid coniine. Only some of the enzymes in the coniine biosynthesis have so…”
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Engineering of Saccharomyces cerevisiae for anthranilate and methyl anthranilate production by Kuivanen, Joosu, Kannisto, Matti, Mojzita, Dominik, Rischer, Heiko, Toivari, Mervi, Jäntti, Jussi

“…Anthranilate is a platform chemical used by the industry in the synthesis of a broad range of high-value products, such as dyes, perfumes and pharmaceutical…”
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Editorial: Plant cell factories: current and future uses of plant cell cultures by Häkkinen, Suvi Tuulikki, Legay, Sylvain, Rischer, Heiko, Renaut, Jenny, Guerriero, Gea

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Variation in the fatty acid profiles of two cold water diatoms grown under different temperature, light, and nutrient regimes by Spilling, Kristian, Seppälä, Jukka, Schwenk, Dagmar, Rischer, Heiko, Tamminen, Timo

“…There is a growing demand for marine omega-3 fatty acids (FAs) that is produced in high amounts by some microalgae. Here we determined the FA profiles of two…”
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Plant cell cultures as food—aspects of sustainability and safety by Häkkinen, Suvi T., Nygren, Heli, Nohynek, Liisa, Puupponen-Pimiä, Riitta, Heiniö, Raija-Liisa, Maiorova, Natalia, Rischer, Heiko, Ritala, Anneli

“…Key message Sustainability and safety aspects of plant cell cultures as food are presented. Applicability of dairy side streams as carbon source and use of…”
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Metabolite profiling of the carnivorous pitcher plants Darlingtonia and Sarracenia by Hotti, Hannu, Gopalacharyulu, Peddinti, Seppänen-Laakso, Tuulikki, Rischer, Heiko

“…Sarraceniaceae is a New World carnivorous plant family comprising three genera: Darlingtonia, Heliamphora, and Sarracenia. The plants occur in nutrient-poor…”
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CathaCyc, a metabolic pathway database built from Catharanthus roseus RNA-Seq data by Van Moerkercke, Alex, Fabris, Michele, Pollier, Jacob, Baart, Gino J E, Rombauts, Stephane, Hasnain, Ghulam, Rischer, Heiko, Memelink, Johan, Oksman-Caldentey, Kirsi-Marja, Goossens, Alain

“…The medicinal plant Madagascar periwinkle (Catharanthus roseus) synthesizes numerous terpenoid indole alkaloids (TIAs), such as the anticancer drugs…”
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Vacuolar transport of nicotine is mediated by a multidrug and toxic compound extrusion (MATE) transporter in Nicotiana tabacum by Morita, Masahiko, Shitan, Nobukazu, Sawada, Keisuke, Van Montagu, Marc C.E, Inzé, Dirk, Rischer, Heiko, Goossens, Alain, Oksman-Caldentey, Kirsi-Marja, Moriyama, Yoshinori, Yazaki, Kazufumi

“…Alkaloids play a key role in plant defense mechanisms against pathogens and herbivores, but the plants themselves need to cope with their toxicity as well. The…”
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Comparative transcriptome analysis of Veratrum maackii and Veratrum nigrum reveals multiple candidate genes involved in steroidal alkaloid biosynthesis by Wang, Dan, Yu, Zhijing, Guan, Meng, Cai, Qinan, Wei, Jia, Ma, Pengda, Xue, Zheyong, Ma, Rui, Oksman-Caldentey, Kirsi-Marja, Rischer, Heiko

“…Veratrum (Melanthiaceae; Liliales) is a genus of perennial herbs known for the production of unique bioactive steroidal alkaloids. However, the biosynthesis of…”
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Jasmonate signaling involves the abscisic acid receptor PYL4 to regulate metabolic reprogramming in Arabidopsis and tobacco by Lackman, Petri, González-Guzmán, Miguel, Tilleman, Sofie, Carqueijeiro, Inês, Pérez, Amparo Cuéllar, Moses, Tessa, Seo, Mitsunori, Kanno, Yuri, Häkkinen, Suvi T, Van Montagu, Marc C.E, Thevelein, Johan M, Maaheimo, Hannu, Oksman-Caldentey, Kirsi-Marja, Rodriguez, Pedro L, Rischer, Heiko, Goossens, Alain

“…The phytohormones jasmonates (JAs) constitute an important class of elicitors for many plant secondary metabolic pathways. However, JAs do not act…”
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Tobacco BY-2 Media Component Optimization for a Cost-Efficient Recombinant Protein Production by Häkkinen, Suvi T, Reuter, Lauri, Nuorti, Ninni, Joensuu, Jussi J, Rischer, Heiko, Ritala, Anneli

“…Plant cells constitute an attractive platform for production of recombinant proteins as more and more animal-free products and processes are desired. One of…”
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Distribution of Acetogenic Naphthoquinones in Droseraceae and Their Chemotaxonomic Utility by Schlauer, Jan, Fleischmann, Andreas, Hartmeyer, Siegfried R H, Hartmeyer, Irmgard, Rischer, Heiko

“…Chemotaxonomy is the link between the state of the art in analytical chemistry and the systematic classification and phylogenetic analysis of biota. Although…”
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Marine Microalgae: Promising Source for New Bioactive Compounds by de Vera, Caterina R, Díaz Crespín, Guillermo, Hernández Daranas, Antonio, Montalvão Looga, Sofia, Lillsunde, Katja-Emilia, Tammela, Päivi, Perälä, Merja, Hongisto, Vesa, Virtanen, Johannes, Rischer, Heiko, Muller, Christian D, Norte, Manuel, Fernández, José J, Souto, María L

“…The study of marine natural products for their bioactive potential has gained strength in recent years. Oceans harbor a vast variety of organisms that offer a…”
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Plant cells as pharmaceutical factories by Rischer, Heiko, Häkkinen, Suvi T, Ritala, Anneli, Seppänen-Laakso, Tuulikki, Miralpeix, Bruna, Capell, Teresa, Christou, Paul, Oksman-Caldentey, Kirsi-Marja

“…Molecules derived from plants make up a sizeable proportion of the drugs currently available on the market. These include a number of secondary metabolite…”
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Gene-to-metabolite networks for terpenoid indole alkaloid biosynthesis in Catharanthus roseus cells by Rischer, H, Oresic, M, Seppanen-Laakso, T, Katajamaa, M, Lammertyn F, Ardiles-Diaz, W, Montagu, M.C.E. van, Inze, D, Oksman-Caldentey, K.M, Goossens, A

“…Rational engineering of complicated metabolic networks involved in the production of biologically active plant compounds has been greatly impeded by our poor…”
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Editorial: Proceedings of ISPMF 2018 - Plant Molecular Farming by Ritala, Anneli, Rischer, Heiko, Häkkinen, Suvi Tuulikki, Joensuu, Jussi Joonas, Oksman-Caldentey, Kirsi-Marja

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Polyketide synthases from poison hemlock (Conium maculatum L.) by Hotti, Hannu, Seppänen‐Laakso, Tuulikki, Arvas, Mikko, Teeri, Teemu H, Rischer, Heiko

“…Coniine is a toxic alkaloid, the biosynthesis of which is not well understood. A possible route, supported by evidence from labelling experiments, involves a…”
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