Serum Vitamin D Concentration Does Not Predict Insulin Action or Secretion in European Subjects With the Metabolic Syndrome

OBJECTIVE: To investigate the relation between serum concentration of 25-hydroxyvitamin D [25(OH)D] and insulin action and secretion. RESEARCH DESIGN AND METHODS: In a cross-sectional study of 446 Pan-European subjects with the metabolic syndrome, insulin action and secretion were assessed by homeos...

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Published in:	Diabetes care Vol. 33; no. 4; pp. 923 - 925
Main Authors:	Gulseth, Hanne L, Gjelstad, Ingrid M.F, Tierney, Audrey C, Lovegrove, Julie A, Defoort, Catherine, Blaak, Ellen E, Lopez-Miranda, Jose, Kiec-Wilk, Beata, Ris, Ulférus, Roche, Helen M, Drevon, Christian A, Birkeland, Kåre I
Format:	Journal Article
Language:	English
Published:	Alexandria, VA American Diabetes Association 01-04-2010
Subjects:	Adult Aged Alfacalcidol Biological and medical sciences Blood pressure Calcifediol Cross-Sectional Studies Diabetes Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Female Health aspects Humans Insulin Male Mass spectrometry Medical sciences MEDICIN MEDICINE Metabolic diseases Metabolic Syndrome - blood Metabolic syndrome X Middle Aged Miscellaneous Nutrition Nutrition research Original Research Other metabolic disorders Physiological aspects Public health. Hygiene Public health. Hygiene-occupational medicine Regression analysis Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin deficiency Europe Austria Endocrinopathy Human Pancreatic hormone Nutrition Secretion Prediction Cardiovascular disease Metabolic diseases Concentration European Metabolic syndrome Insulin Vitamin D Serum Predictive factor Endocrinology Public health
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Summary:	OBJECTIVE: To investigate the relation between serum concentration of 25-hydroxyvitamin D [25(OH)D] and insulin action and secretion. RESEARCH DESIGN AND METHODS: In a cross-sectional study of 446 Pan-European subjects with the metabolic syndrome, insulin action and secretion were assessed by homeostasis model assessment (HOMA) indexes and intravenous glucose tolerance test to calculate acute insulin response, insulin sensitivity, and disposition index. Serum 25(OH)D was measured by high-performance liquid chromatography/mass spectrometry. RESULTS: The 25(OH)D₃ concentration was 57.1 ± 26.0 nmol/l (mean ± SD), and only 20% of the subjects had 25(OH)D₃ levels ≥75 nmol/l. In multiple linear analyses, 25(OH)D₃ concentrations were not associated with parameters of insulin action or secretion after adjustment for BMI and other covariates. CONCLUSIONS: In a large sample of subjects with the metabolic syndrome, serum concentrations of 25(OH)D₃ did not predict insulin action or secretion. Clear evidence that D vitamin status directly influences insulin secretion or action is still lacking.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0149-5992 1935-5548 1935-5548
DOI:	10.2337/dc09-1692