Search Results - "Ripplinger, M."

Antiarrhythmic mechanisms of beta blocker therapy by Grandi, Eleonora, Ripplinger, Crystal M.

“…•β-Blockers are effective antiarrhythmics in many cardiac diseases.•β-Adrenergic effects on cardiac function are complex, and involve changes occurring over…”
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Guidelines for experimental models of myocardial ischemia and infarction by Lindsey, Merry L, Bolli, Roberto, Canty, Jr, John M, Du, Xiao-Jun, Frangogiannis, Nikolaos G, Frantz, Stefan, Gourdie, Robert G, Holmes, Jeffrey W, Jones, Steven P, Kloner, Robert A, Lefer, David J, Liao, Ronglih, Murphy, Elizabeth, Ping, Peipei, Przyklenk, Karin, Recchia, Fabio A, Schwartz Longacre, Lisa, Ripplinger, Crystal M, Van Eyk, Jennifer E, Heusch, Gerd

“…Myocardial infarction is a prevalent major cardiovascular event that arises from myocardial ischemia with or without reperfusion, and basic and translational…”
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Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation by Erickson, Jeffrey R., Pereira, Laetitia, Wang, Lianguo, Han, Guanghui, Ferguson, Amanda, Dao, Khanha, Copeland, Ronald J., Despa, Florin, Hart, Gerald W., Ripplinger, Crystal M., Bers, Donald M.

“…CaMKII is known to be pathologically activated in heart failure and arrhythmias; here it is shown that glucose-induced CaMKII activation via O -linked…”
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The crossroads of inflammation, fibrosis, and arrhythmia following myocardial infarction by Francis Stuart, Samantha D, De Jesus, Nicole M, Lindsey, Merry L, Ripplinger, Crystal M

“…Abstract Optimal healing of damaged tissue following myocardial infarction (MI) requires a coordinated cellular response that can be divided into three phases:…”
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Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture by Feinberg, Adam W, Alford, Patrick W, Jin, Hongwei, Ripplinger, Crystal M, Werdich, Andreas A, Sheehy, Sean P, Grosberg, Anna, Parker, Kevin Kit

“…Abstract The heart is a muscular organ with a wrapping, laminar structure embedded with neural and vascular networks, collagen fibrils, fibroblasts, and…”
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CaMKII Serine 280 O-GlcNAcylation Links Diabetic Hyperglycemia to Proarrhythmia by Hegyi, Bence, Fasoli, Anna, Ko, Christopher Y., Van, Benjamin W., Alim, Chidera C., Shen, Erin Y., Ciccozzi, Marisa M., Tapa, Srinivas, Ripplinger, Crystal M., Erickson, Jeffrey R., Bossuyt, Julie, Bers, Donald M.

“…[Figure: see text]…”
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Molecular and cellular neurocardiology: development, and cellular and molecular adaptations to heart disease by Habecker, Beth A., Anderson, Mark E., Birren, Susan J., Fukuda, Keiichi, Herring, Neil, Hoover, Donald B., Kanazawa, Hideaki, Paterson, David J., Ripplinger, Crystal M.

“…The nervous system and cardiovascular system develop in concert and are functionally interconnected in both health and disease. This white paper focuses on the…”
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Guidelines for in vivo mouse models of myocardial infarction by Lindsey, Merry L, Brunt, Keith R, Kirk, Jonathan A, Kleinbongard, Petra, Calvert, John W, de Castro Brás, Lisandra E, DeLeon-Pennell, Kristine Y, Del Re, Dominic P, Frangogiannis, Nikolaos G, Frantz, Stefan, Gumina, Richard J, Halade, Ganesh V, Jones, Steven P, Ritchie, Rebecca H, Spinale, Francis G, Thorp, Edward B, Ripplinger, Crystal M, Kassiri, Zamaneh

“…Despite significant improvements in reperfusion strategies, acute coronary syndromes all too often culminate in a myocardial infarction (MI). The consequent MI…”
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Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics by Chiamvimonvat, Nipavan, Chen‐Izu, Ye, Clancy, Colleen E., Deschenes, Isabelle, Dobrev, Dobromir, Heijman, Jordi, Izu, Leighton, Qu, Zhilin, Ripplinger, Crystal M., Vandenberg, Jamie I., Weiss, James N., Koren, Gideon, Banyasz, Tamas, Grandi, Eleonora, Sanguinetti, Michael C., Bers, Donald M., Nerbonne, Jeanne M.

“…This is the second of the two White Papers from the fourth UC Davis Cardiovascular Symposium Systems Approach to Understanding Cardiac Excitation–Contraction…”
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Automated Object Detection in Experimental Data Using Combination of Unsupervised and Supervised Methods by Wu, Yiran, Wang, Zhen, Ripplinger, Crystal M, Sato, Daisuke

“…Deep neural networks (DNN) have shown their success through computer vision tasks such as object detection, classification, and segmentation of image data…”
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Myocardial Infarction Causes Transient Cholinergic Transdifferentiation of Cardiac Sympathetic Nerves via gp130 by Olivas, Antoinette, Gardner, Ryan T, Wang, Lianguo, Ripplinger, Crystal M, Woodward, William R, Habecker, Beth A

“…Sympathetic and parasympathetic control of the heart is a classic example of norepinephrine (NE) and acetylcholine (ACh) triggering opposing actions…”
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Role of Reduced Sarco-Endoplasmic Reticulum Ca2+-ATPase Function on Sarcoplasmic Reticulum Ca2+ Alternans in the Intact Rabbit Heart by Wang, Lianguo, Myles, Rachel C., Lee, I-Ju, Bers, Donald M., Ripplinger, Crystal M.

“…Sarcoplasmic reticulum (SR) Ca 2+ cycling is tightly regulated by ryanodine receptor (RyR) Ca 2+ release and sarco-endoplasmic reticulum Ca 2+ -ATPase (SERCA)…”
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A computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythms by Moreno, Jonathan D, Zhu, Z Iris, Yang, Pei-Chi, Bankston, John R, Jeng, Mao-Tsuen, Kang, Chaoyi, Wang, Lianguo, Bayer, Jason D, Christini, David J, Trayanova, Natalia A, Ripplinger, Crystal M, Kass, Robert S, Clancy, Colleen E

“…A long-sought, and thus far elusive, goal has been to develop drugs to manage diseases of excitability. One such disease that affects millions each year is…”
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Antiarrhythmic effects of interleukin 1 inhibition after myocardial infarction by De Jesus, Nicole M., PhD, Wang, Lianguo, MD, Lai, Johnny, BS, Rigor, Robert R., PhD, Francis Stuart, Samantha D., MS, Bers, Donald M., PhD, Lindsey, Merry L., PhD, Ripplinger, Crystal M., PhD, FHRS

“…Background Interleukin 1β (IL-1β) is a key regulator of the inflammatory response after myocardial infarction (MI) by modulating immune cell recruitment,…”
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Decreased inward rectifying K+ current and increased ryanodine receptor sensitivity synergistically contribute to sustained focal arrhythmia in the intact rabbit heart by Myles, Rachel C., Wang, Lianguo, Bers, Donald M., Ripplinger, Crystal M.

“…Key points Heart failure leads to dramatic electrophysiological remodelling as a result of numerous cellular and tissue‐level changes. Important cellular…”
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Atherosclerosis exacerbates arrhythmia following myocardial infarction: Role of myocardial inflammation by De Jesus, Nicole M., BS, Wang, Lianguo, MD, Herren, Anthony W., BS, Wang, Jingjing, PhD, Shenasa, Fatemah, Bers, Donald M., PhD, Lindsey, Merry L., PhD, Ripplinger, Crystal M., PhD

“…Background Atherosclerotic animal models show increased recruitment of inflammatory cells to the heart after myocardial infarction (MI), which impacts…”
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P. gingivalis lipopolysaccharide intensifies inflammation post-myocardial infarction through matrix metalloproteinase-9 by DeLeon-Pennell, Kristine Y, de Castro Brás, Lisandra E, Iyer, Rugmani Padmanabhan, Bratton, Dustin R, Jin, Yu-Fang, Ripplinger, Crystal M, Lindsey, Merry L

“…Abstract Periodontal disease (PD) strongly correlates with increased mortality post-myocardial infarction (MI); however, the underlying mechanisms are unknown…”
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Mouse models of cardiac conduction system markers: Revealing the past, present, and future of pacemaking and conduction by Ripplinger, Crystal M., PhD

“…Fortunately, recent years have seen an explosion of genetically modified mouse models that have greatly aided our ability to visualize and characterize the…”
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Molecular Mechanisms and New Treatment Paradigm for Atrial Fibrillation by Sirish, Padmini, Li, Ning, Timofeyev, Valeriy, Zhang, Xiao-Dong, Wang, Lianguo, Yang, Jun, Lee, Kin Sing Stephen, Bettaieb, Ahmed, Ma, Sin Mei, Lee, Jeong Han, Su, Demetria, Lau, Victor C, Myers, Richard E, Lieu, Deborah K, López, Javier E, Young, J Nilas, Yamoah, Ebenezer N, Haj, Fawaz, Ripplinger, Crystal M, Hammock, Bruce D, Chiamvimonvat, Nipavan

“…BACKGROUND—Atrial fibrillation represents the most common arrhythmia leading to increased morbidity and mortality, yet, current treatment strategies have…”
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The heart of physiological reports by Lindsey, Merry L, Brunt, Keith R, Kleinbongard, Petra, Carter, Jason R, Ripplinger, Crystal M, Kassiri, Zamaneh, Hansell Keehan, Kara, LeBlanc, Amanda J, Kirk, Jonathan A

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