Search Results - "Rioux, Patrice"

A0001 in Friedreich ataxia: Biochemical characterization and effects in a clinical trial by Lynch, David R., Willi, Steven M., Wilson, Robert B., Cotticelli, M. Grazia, Brigatti, Karlla W., Deutsch, Eric C., Kucheruk, Olena, Shrader, William, Rioux, Patrice, Miller, Guy, Hawi, Amale, Sciascia, Thomas

“…This study tested the ability of A0001 (α‐tocopheryl quinone; EPI‐A0001), a potent antioxidant, to improve in vitro measures, glucose metabolism, and…”
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A Randomized Controlled Crossover Trial with Delayed-Release Cysteamine Bitartrate in Nephropathic Cystinosis: Effectiveness on White Blood Cell Cystine Levels and Comparison of Safety by Langman, Craig B., Greenbaum, Larry A., Sarwal, Minnie, Grimm, Paul, Niaudet, Patrick, Deschênes, Georges, Cornelissen, Elisabeth, Morin, Denis, Cochat, Pierre, Matossian, Debora, Gaillard, Segolene, Bagger, Mary Jo, Rioux, Patrice

“…Immediate-release cysteamine bitartrate (Cystagon; Mylan Pharmaceuticals, Canonsburg, PA) may prevent or delay kidney transplantation and other serious…”
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Quality of Life is Improved and Kidney Function Preserved in Patients with Nephropathic Cystinosis Treated for 2 Years with Delayed-Release Cysteamine Bitartrate by Langman, Craig B., MD, Greenbaum, Larry A., MD, PhD, Grimm, Paul, MD, PhD, Sarwal, Minnie, MD, PhD, Niaudet, Patrick, MD, Deschenes, Georges, MD, PhD, Cornelissen, Elisabeth A.M., MD, Morin, Denis, MD, Cochat, Pierre, MD, Elenberg, Ewa, MD, MS, Hanna, Christian, MD, MS, Gaillard, Segolene, MD, Bagger, Mary Jo, MS, Rioux, Patrice, MD, PhD

“…Objectives To determine the long-term effects of delayed-release cysteamine bitartrate (DR-CYS) based on our previous work that established the short-term…”
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Selective killing of cancer cells based on loss of heterozygosity and normal variation in the human genome: a new paradigm for anticancer drug therapy by Basilion, J P, Schievella, A R, Burns, E, Rioux, P, Olson, J C, Monia, B P, Lemonidis, K M, Stanton, Jr, V P, Housman, D E

“…Most drugs for cancer therapy are targeted to relative differences in the biological characteristics of cancer cells and normal cells. The therapeutic index of…”
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Intravenous infusion of iduronidase-IgG and its impact on the central nervous system in children with Hurler syndrome by Giugliani, Roberto, Nestrasil, Igor, Chen, Steven, Pardridge, William, Rioux, Patrice

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Pharmacokinetic Studies of Cysteamine Bitartrate Delayed-Release by Dohil, Ranjan, Rioux, Patrice

“…A twice‐daily microsphere formulation of cysteamine bitartrate has been developed for cystinosis and other potential applications. To date, there are no…”
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Halitosis in cystinosis patients after administration of immediate-release cysteamine bitartrate compared to delayed-release cysteamine bitartrate by Besouw, Martine, Tangerman, Albert, Cornelissen, Elisabeth, Rioux, Patrice, Levtchenko, Elena

“…Halitosis due to dimethylsulfide (DMS) generation is a major side effect of cysteamine in the treatment of cystinosis. Recently, an enteric coated formulation…”
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Central benzodiazepine receptor occupancy by zolpidem in the human brain as assessed by positron emission tomography by Abadie, Pascale, Rioux, Patrice, Scatton, Bernard, Zarifian, Edouard, Barré, Louisa, Patat, Alain, Baron, Jean-Claude

“…The central benzodiazepine receptor occupancy by zolpidem in man is unknown. The present study used positron emission tomography (PET) and [ 11C]flumazenil to…”
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120. Correlation of plasma cysteamine and WBC cystine levels at steady state in patients treated with cysteamine bitartrate by Rioux, Patrice, Gangoiti, Jon

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Controversies and research agenda in nephropathic cystinosis: conclusions from a "Kidney Disease: Improving Global Outcomes" (KDIGO) Controversies Conference by Langman, Craig B, Barshop, Bruce A, Deschênes, Georges, Emma, Francesco, Goodyer, Paul, Lipkin, Graham, Midgley, Julian P, Ottolenghi, Chris, Servais, Aude, Soliman, Neveen A, Thoene, Jess G, Levtchenko, Elena N

“…Nephropathic cystinosis is an autosomal recessive metabolic, lifelong disease characterized by lysosomal cystine accumulation throughout the body that commonly…”
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Pharmacokinetics of cysteamine bitartrate following intraduodenal delivery by Dohil, Ranjan, Cabrera, Betty L., Gangoiti, Jon A., Barshop, Bruce A., Rioux, Patrice

“…Cysteamine is approved for the treatment of cystinosis and is being evaluated for Huntington's disease and non‐alcoholic fatty liver disease. Little is known…”
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Unilateral eyeball enucleation differentially alters AMPA-, NMDA- and kainate glutamate receptor binding in the newborn rat brain by Kiyosawa, Motohiro, Dauphin, François, Kawasaki, Tsutomu, Rioux, Patrice, Tokoro, Takashi, MacKenzie, Eric T., Baron, Jean-Claude

“…The aim of the present work was to evaluate the neurochemical effects of early unilateral visual deprivation as a model of impaired visual maturation. For this…”
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Towards a modern definition of vitamin E—evidence for a quinone hypothesis by Shrader, William D., Amagata, Akiko, Barnes, Adam, Hinman, Andrew, Jankowski, Orion, Lee, Edgar, Kheifets, Viktoria, Komatsuzaki, Ryo, Mollard, Paul, Murase, Katsuyuki, Rioux, Patrice, Wesson, Kieron, Miller, Guy

“…We report on the synthesis, biological and pharmacological activity of the tocoquinone natural product, α-tocopherol quinone (ATQ); an oxidative metabolite of…”
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Towards a modern definition of vitamin E&; mdash; evidence for a quinone hypothesis by Shrader, William D, Amagata, Akiko, Barnes, Adam, Hinman, Andrew, Jankowski, Orion, Lee, Edgar, Kheifets, Viktoria, Komatsuzaki, Ryo, Mollard, Paul, Murase, Katsuyuki, Rioux, Patrice, Wesson, Kieron, Miller, Guy

“…We report on the synthesis, biological and pharmacological activity of the tocoquinone natural product, alpha -tocopherol quinone (ATQ); an oxidative…”
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The Effect of Food on Cysteamine Bitartrate Absorption in Healthy Participants by Dohil, Ranjan, Cabrera, Betty L., Gangoiti, Jon, Rioux, Patrice

“…Objectives: Treatment with cysteamine reduces the rate of progression to end‐stage kidney disease in cystinosis. Although food is often taken with cysteamine…”
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Prolonged persistence of substantial volumes of potentially viable brain tissue after stroke: a correlative PET-CT study with voxel-based data analysis by Marchal, G, Beaudouin, V, Rioux, P, de la Sayette, V, Le Doze, F, Viader, F, Derlon, J M, Baron, J C

“…The existence in humans of brain tissue at risk for infarction but potentially viable (eg, the penumbra) remains unproven. One retrospective operational…”
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Clinical trials in pharmacogenetics and pharmacogenomics: methods and applications by Rioux, PP

“…Clinical and other aspects of pharmacogenetics and pharmacogenomics are discussed. Pharmacogenetics is the study of the impact of heritable traits on…”
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Early spontaneous hyperperfusion after stroke : A marker of favourable tissue outcome ? by MARCHAL, G, FURLAN, M, BARON, J. C, BEAUDOUIN, V, RIOUX, P, HAUTTEMENT, J. L, SERRATI, C, DE LA SAYETTE, V, LE DOZE, F, VIADER, F, DERLON, J. M

“…To clarify the relationships between early hyperperfusion (i.e. the hallmark of early, efficient recanalization in animal stroke models) and ultimate…”
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PET imaging of cerebral perfusion and oxygen consumption in acute ischaemic stroke: relation to outcome by Marchal, G, Serrati, C, Rioux, P, Petit-Taboué, M C, Viader, F, de la Sayette, V, Le Doze, F, Lochon, P, Derlon, J M, Orgogozo, J M, Baron, J C

“…We used positron emission tomography (PET) to assess the relation between combined imaging of cerebral blood flow and oxygen consumption 5-18 h after first…”
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Comparative pharmacokinetics and pharmacodynamics of two recombinant human interferon beta-1a (IFNβ-1a) products administered intramuscularly in healthy male and female volunteers by ALAM, J, GOELZ, S, RIOUX, P, SCARAMUCCI, J, JONES, W, MCALLISTER, A, CAMPION, M, ROGGE, M

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