Search Results - "Rios, Cristobal de los"

Ischemic brain injury: New insights on the protective role of melatonin by Ramos, Eva, Patiño, Paloma, Reiter, Russel J., Gil-Martín, Emilio, Marco-Contelles, José, Parada, Esther, de los Rios, Cristobal, Romero, Alejandro, Egea, Javier

“…Stroke represents one of the most common causes of brain's vulnerability for many millions of people worldwide. The plethora of physiopathological events…”
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(±)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer’s Disease by Ismaili, Lhassane, Monnin, Julie, Etievant, Adeline, Arribas, Raquel L, Viejo, Lucía, Refouvelet, Bernard, Soukup, Ondrej, Janockova, Jana, Hepnarova, Vendula, Korabecny, Jan, Kucera, Tomas, Jun, Daniel, Andrys, Rudolf, Musilek, Kamil, Baguet, Aurelie, García-Frutos, Eva M, De Simone, Angela, Andrisano, Vincenza, Bartolini, Manuela, de los Ríos, Cristóbal, Marco-Contelles, José, Haffen, Emmanuel

“…Multitarget-directed ligands (MTDLs) are considered a promising therapeutic strategy to address the multifactorial nature of Alzheimer’s disease (AD). Novel…”
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Novel Purine Derivative ITH15004 Facilitates Exocytosis through a Mitochondrial Calcium-Mediated Mechanism by de Pascual, Ricardo, Calzaferri, Francesco, Gonzalo, Paula C, Serrano-Nieto, Rubén, de Los Ríos, Cristóbal, García, Antonio G, Gandía, Luis

“…Upon depolarization of chromaffin cells (CCs), a prompt release of catecholamines occurs. This event is triggered by a subplasmalemmal high-Ca microdomain…”
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Evaluation of the neuroprotective efficacy of the gramine derivative ITH12657 against NMDA-induced excitotoxicity in the rat retina by Di Pierdomenico, Johnny, Gallego-Ortega, Alejandro, Norte-Muñoz, María, Vidal-Villegas, Beatriz, Bravo, Isaac, Boluda-Ruiz, María, Bernal-Garro, Jose Manuel, Fernandez-Bueno, Iván, Pastor-Jimeno, Jose Carlos, Villegas-Pérez, María Paz, Avilés-Trigueros, Marcelino, de Los Ríos, Cristobal, Vidal-Sanz, Manuel

“…The aim of this study was to investigate, the neuroprotective effects of a new Gramine derivative named: ITH12657, in a model of retinal excitotoxicity induced…”
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Identification of tetracyclic lactams as NMDA receptor antagonists with potential application in neurological disorders by Espadinha, Margarida, Viejo, Lucía, Lopes, Ricardo M.R.M., Herrera-Arozamena, Clara, Molins, Elies, dos Santos, Daniel J.V.A., Gonçalves, Lídia, Rodríguez-Franco, María Isabel, Ríos, Cristóbal de los, Santos, Maria M.M.

“…N-Methyl-d-aspartate receptors (NMDARs) are crucial for the normal function of the central nervous system (CNS), and fundamental in memory and learning-related…”
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The Neuroprotector Benzothiazepine CGP37157 Extends Lifespan in C. elegans Worms by García-Casas, Paloma, Arias-Del-Val, Jessica, Alvarez-Illera, Pilar, Wojnicz, Aneta, de Los Ríos, Cristobal, Fonteriz, Rosalba I, Montero, Mayte, Alvarez, Javier

“…The benzothiazepine CGP37157 has shown neuroprotective effects in several models of excitotoxicity involving dysregulation of intracellular Ca homeostasis…”
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New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties by León, Rafael, Ríos, Cristóbal de los, Marco-Contelles, José, Huertas, Oscar, Barril, Xavier, Javier Luque, F., López, Manuela G., García, Antonio G., Villarroya, Mercedes

“…In this communication, we describe the synthesis and biological evaluation of tacripyrimedones 1– 5, a series of new tacrine-1,4-dihydropyridine hybrids…”
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Synthesis, Pharmacological Assessment, and Molecular Modeling of Acetylcholinesterase/Butyrylcholinesterase Inhibitors: Effect against Amyloid-β-Induced Neurotoxicity by Silva, Daniel, Chioua, Mourad, Samadi, Abdelouahid, Agostinho, Paula, Garção, Pedro, Lajarín-Cuesta, Rocío, de los Ríos, Cristobal, Iriepa, Isabel, Moraleda, Ignacio, Gonzalez-Lafuente, Laura, Mendes, Eduarda, Pérez, Concepción, Rodríguez-Franco, María Isabel, Marco-Contelles, José, Carmo Carreiras, M

“…The synthesis, molecular modeling, and pharmacological analysis of phenoxyalkylamino-4-phenylnicotinates (2–7), phenoxyalkoxybenzylidenemalononitriles (12,…”
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Molecular modelling, synthesis and acetylcholinesterase inhibition of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[ b][1,8]naphthyridine-3-carboxylate by Soriano, Elena, Samadi, Abdelouahid, Chioua, Mourad, Ríos, Cristóbal de los, Marco-Contelles, José

“…In silico analysis of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[ b][1,8]naphthyridine-3-carboxylate ( 2) predicts that this molecule should be…”
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New multipotent tetracyclic tacrines with neuroprotective activity by Marco-Contelles, José, León, Rafael, Ríos, Cristóbal de los, García, Antonio G., López, Manuela G., Villarroya, Mercedes

“…The synthesis and the biological evaluation (neuroprotection, voltage dependent calcium channel blockade, AChE/BuChE inhibitory activity and propidium binding)…”
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Dual Role of the P2X7 Receptor in Dendritic Outgrowth during Physiological and Pathological Brain Development by Mut-Arbona, Paula, Huang, Lumei, Baranyi, Mária, Tod, Pál, Iring, András, Calzaferri, Francesco, de Los Ríos, Cristobal, Sperlágh, Beáta

“…At high levels, extracellular ATP operates as a "danger" molecule under pathologic conditions through purinergic receptors, including the ionotropic P2X7…”
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New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H 3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition by Malek, Rim, Arribas, Raquel L, Palomino-Antolin, Alejandra, Totoson, Perle, Demougeot, Celine, Kobrlova, Tereza, Soukup, Ondrej, Iriepa, Isabel, Moraleda, Ignacio, Diez-Iriepa, Daniel, Godyń, Justyna, Panek, Dawid, Malawska, Barbara, Głuch-Lutwin, Monika, Mordyl, Barbara, Siwek, Agata, Chabchoub, Fakher, Marco-Contelles, José, Kiec-Kononowicz, Katarzyna, Egea, Javier, de Los Ríos, Cristóbal, Ismaili, Lhassane

“…New tritarget small molecules combining Ca channels blockade, cholinesterase, and H3 receptor inhibition were obtained by multicomponent synthesis. Compound…”
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Study of the single or combined action of three different neuroprotection strategies in an acute hypertension model in mice by Valiente‐Soriano, Francisco Javier, Ortega, Alejandro Gallego, Muñoz, María Norte, Rios, Cristobal De Los, Agudo‐Barriuso, Marta, Vidal‐Sanz, Manuel

“…Aims/Purpose: To study the neuroprotective effects of a TrkB receptor activator (DHF), a calcium channel blocker that prevents Ca2+ toxic influx (ITH12657)…”
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Synthesis, biological evaluation and molecular modelling of diversely functionalized heterocyclic derivatives as inhibitors of acetylcholinesterase/butyrylcholinesterase and modulators of Ca2+ channels and nicotinic receptors by MARCO, José L, DE LOS RIOS, Cristobal, GARCIA, Antonio G, VILLARROYA, Mercedes, CARREIRAS, M. Carmo, MARTINS, Carla, ELEUTERIO, Ana, MORREALE, Antonio, OROZCO, M, LUQUE, F. Javier

“…The synthesis and the biological activity of compounds 5-40 as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), as well as…”
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P2X7R and TNFR1 antagonism neuroprotects rodent retinal ganglion cells in a sepsis model by Ramírez, Kristy Tatiana Rodríguez, Calzaferri, Francesco, Rios, Cristobal De Los, Vidal‐Sanz, Manuel, Agudo‐Barriuso, Marta

“…Purpose: i/ To analyse the time course of retinal ganglion cell death (RGCs) after systemic injection of LPS in mice. ii/ To analyse the neuroprotective effect…”
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Tetrabenazine Facilitates Exocytosis by Enhancing Calcium-Induced Calcium Release through Ryanodine Receptors by de Pascual, Ricardo, Álvarez-Ortego, Nuria, de Los Ríos, Cristóbal, Jacob-Mazariego, Gema, García, Antonio G

“…Vesicular monoamine transporter-2 is expressed in the presynaptic secretory vesicles membrane in the brain. Its blockade by tetrabenazine (TBZ) causes…”
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Therapeutic concentrations of varenicline increases exocytotic release of catecholamines from human and rat adrenal chromaffin cells in the presence of nicotine by Jiménez-Pompa, Amanda, Sanz-Lázaro, Sara, Hone, Arik J., Rueda-Ruzafa, Lola, Medina-Polo, José, González-Enguita, Carmen, Blázquez, Jesús, de los Ríos, Cristóbal, Michael McIntosh, J., Albillos, Almudena

“…Cardiovascular side effects of varenicline and a case report of a hypertensive crisis in a varenicline-prescribed patient with pheochromocytoma have been…”
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Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles by Samadi, Abdelouahid, Valderas, Carolina, Ríos, Cristóbal de los, Bastida, Agatha, Chioua, Mourad, González-Lafuente, Laura, Colmena, Inés, Gandía, Luis, Romero, Alejandro, Barrio, Laura del, Martín-de-Saavedra, María D., López, Manuela G., Villarroya, Mercedes, Marco-Contelles, José

“…The structures of tacrine, the 2-aminopyridine-3,5-dicarbonitrile precursors, and the new tacrine analogues. The synthesis, biological assessment, and…”
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Synthesis, Biological Evaluation, and Molecular Modeling of Donepezil and N-[(5-(Benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine Hybrids as New Multipotent Cholinesterase/Monoamine Oxidase Inhibitors for the Treatment of Alzheimer’s Disease by Bolea, Irene, Juárez-Jiménez, Jordi, de los Rı́os, Cristóbal, Chioua, Mourad, Pouplana, Ramón, Luque, F. Javier, Unzeta, Mercedes, Marco-Contelles, José, Samadi, Abdelouahid

“…A new family of multitarget molecules able to interact with acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), as well as with monoamino oxidase…”
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1,8-Naphthyridine derivatives as cholinesterases inhibitors and cell Ca2+ regulators, a multitarget strategy for Alzheimer's disease by Egea, Javier, de los Rios, Cristobal

“…The synthesis and the pharmacological evaluation of 1,8-naphthyridine derivatives and related compounds as inhibitors of acetylcholinesterase (AChE) and…”
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