Search Results - "Rinsch, Chris"

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging by D’Amico, Davide, Andreux, Pénélope A., Valdés, Pamela, Singh, Anurag, Rinsch, Chris, Auwerx, Johan

“…Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins (ETs) and ellagic acid (EA), complex polyphenols abundant in foods…”
Get full text

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents by Ryu, Dongryeol, Mouchiroud, Laurent, Andreux, Pénélope A, Katsyuba, Elena, Moullan, Norman, Nicolet-dit-Félix, Amandine A, Williams, Evan G, Jha, Pooja, Lo Sasso, Giuseppe, Huzard, Damien, Aebischer, Patrick, Sandi, Carmen, Rinsch, Chris, Auwerx, Johan

“…The naturally occurring compound urolithin A has been found to promote mitophagy, thereby increasing lifespan in worms and improving skeletal muscle activity…”
Get full text

Safety assessment of Urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid by Heilman, Jacqueline, Andreux, Pénélope, Tran, Nga, Rinsch, Chris, Blanco-Bose, William

“…Urolithins are metabolites produced in the gut following consumption of ellagitannins and ellagic acid rich foods such as pomegranates, nuts and certain…”
Get full text

Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population by Singh, Anurag, D’Amico, Davide, Andreux, Pénélope A., Dunngalvin, Gillian, Kern, Timo, Blanco-Bose, William, Auwerx, Johan, Aebischer, Patrick, Rinsch, Chris

“…Background Urolithin A (UA) is produced by gut microflora from foods rich in ellagitannins. UA has been shown to improve mitochondrial health preclinically and…”
Get full text

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans by Andreux, Pénélope A., Blanco-Bose, William, Ryu, Dongryeol, Burdet, Frédéric, Ibberson, Mark, Aebischer, Patrick, Auwerx, Johan, Singh, Anurag, Rinsch, Chris

“…Urolithin A (UA) is a natural dietary, microflora-derived metabolite shown to stimulate mitophagy and improve muscle health in old animals and in preclinical…”
Get full text

Mitophagy Activation by Urolithin A to Target Muscle Aging by Faitg, Julie, D’Amico, Davide, Rinsch, Chris, Singh, Anurag

“…The age-related loss of skeletal muscle function starts from midlife and if left unaddressed can lead to an impaired quality of life. A growing body of…”
Get full text

Tetracycline-regulated expression of VEGF-A in beta cells induces angiogenesis: improvement of engraftment following transplantation by Mathe, Zoltan, Dupraz, Philippe, Rinsch, Chris, Thorens, Bernard, Bosco, Domenico, Zbinden, Marie, Morel, Philippe, Berney, Thierry, Pepper, Michael S

“…Early revascularization of pancreatic islet cells after transplantation is crucial for engraftment, and it has been suggested that vascular endothelial growth…”
Get full text

Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis by D'Amico, Davide, Olmer, Merissa, Fouassier, Andréane M., Valdés, Pamela, Andreux, Pénélope A., Rinsch, Chris, Lotz, Martin

“…Osteoarthritis (OA) is the most common age‐related joint disorder with no effective therapy. According to the World Health Organization, OA affects over 500…”
Get full text

Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy by Denk, Dominic, Petrocelli, Valentina, Conche, Claire, Drachsler, Moritz, Ziegler, Paul K., Braun, Angela, Kress, Alena, Nicolas, Adele M., Mohs, Kathleen, Becker, Christoph, Neurath, Markus F., Farin, Henner F., Buchholz, Christian J., Andreux, Pénélope A., Rinsch, Chris, Greten, Florian R.

“…T memory stem cells (TSCM) display increased self-renewal and prolonged survival capabilities, thus preventing T cell exhaustion and promoting effective…”
Get full text

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity by Cantó, Carles, Houtkooper, Riekelt H., Pirinen, Eija, Youn, Dou Y., Oosterveer, Maaike H., Cen, Yana, Fernandez-Marcos, Pablo J., Yamamoto, Hiroyasu, Andreux, Pénélope A., Cettour-Rose, Philippe, Gademann, Karl, Rinsch, Chris, Schoonjans, Kristina, Sauve, Anthony A., Auwerx, Johan

“…As NAD+ is a rate-limiting cosubstrate for the sirtuin enzymes, its modulation is emerging as a valuable tool to regulate sirtuin function and, consequently,…”
Get full text

Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults by Singh, Anurag, D’Amico, Davide, Andreux, Pénélope A., Fouassier, Andréane M., Blanco-Bose, William, Evans, Mal, Aebischer, Patrick, Auwerx, Johan, Rinsch, Chris

“…Targeting mitophagy to activate the recycling of faulty mitochondria during aging is a strategy to mitigate muscle decline. We present results from a…”
Get full text

Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial by Liu, Sophia, D'Amico, Davide, Shankland, Eric, Bhayana, Saakshi, Garcia, Jose M, Aebischer, Patrick, Rinsch, Chris, Singh, Anurag, Marcinek, David J

“…Aging is associated with a decline in mitochondrial function and reduced exercise capacity. Urolithin A is a natural gut microbiome-derived food metabolite…”
Get full text

Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly by Andreux, Pénélope A., van Diemen, Marcus P. J., Heezen, Maxime R., Auwerx, Johan, Rinsch, Chris, Groeneveld, Geert Jan, Singh, Anurag

“…Aging is accompanied by a gradual decline in both muscle mass and strength over time, which can eventually lead to pathologies, such as frailty and sarcopenia…”
Get full text

Publisher Correction: Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly by Andreux, Pénélope A., van Diemen, Marcus P. J., Heezen, Maxime R., Auwerx, Johan, Rinsch, Chris, Groeneveld, Geert Jan, Singh, Anurag

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
Get full text

Urolithin A, a Gut Microbiome Derived Metabolite Improves Mitochondrial and Cellular Health: Results from a Randomized, Placebo-controlled, Double-blind Clinical Trial (FS09-06-19) by Singh, Anurag, Andreux, Pénélope, Blanco, William, Auwerx, Johan, Rinsch, Chris

“…Muscle health declines with aging and is accompanied by impairment of skeletal muscle mitochondrial function. Strategies targeting improvements in…”
Get full text

Generation and Characterization of Telomerase-Transfected Human Lymphatic Endothelial Cells with an Extended Life Span by Nisato, Riccardo E., Harrison, Jillian A., Buser, Raphaele, Orci, Lelio, Rinsch, Chris, Montesano, Roberto, Dupraz, Philippe, Pepper, Michael S.

“…The study of lymphatic endothelial cells and lymphangiogenesis has, in the past, been hampered by the lack of lymphatic endothelial-specific markers. The…”
Get full text