The association between risk of airflow limitation and serum uric acid measured at medical health check-ups

The association between risk of airflow limitation and serum uric acid measured at medical health check-ups

The prevalence of COPD and asthma is increasing all over the world; however, their morbidities are thought to be greatly underestimated because of unawareness of patients' conditions and respiratory symptoms. Spirometry is useful for the early detection of COPD and asthma with airflow limitatio...

Full description

Saved in:
Bibliographic Details
Published in:International journal of chronic obstructive pulmonary disease Vol. 12; pp. 1213 - 1219
Main Authors: Fukuhara, Atsuro, Saito, Junpei, Sato, Suguru, Saito, Kazue, Fukuhara, Naoko, Tanino, Yoshinori, Wang, Xintao, Rinno, Katsuaki, Suzuki, Hitoshi, Munakata, Mitsuru
Format: Journal Article
Language:English
Published: New Zealand Dove Medical Press Limited 01-01-2017
Dove Medical Press Ltd
Dove Medical Press
Subjects:
Adult
Aged
airflow limitation
Asthma
Asthma - diagnosis
Asthma - epidemiology
Asthma - physiopathology
Biomarkers - blood
Blood pressure
Body mass index
Cholesterol
Chronic obstructive lung disease
Complications and side effects
COPD
Creatinine
Diagnosis
Dyspnea
Female
Forced Expiratory Volume
Hemoglobin
High density lipoprotein
Humans
Hyperuricemia - blood
Hyperuricemia - diagnosis
Hyperuricemia - epidemiology
Japan - epidemiology
Lipoproteins
Logistic Models
Lung - physiopathology
Male
Measurement
Methods
Middle Aged
Multivariate Analysis
Odds Ratio
Original Research
Physiological aspects
Predictive Value of Tests
Prevalence
Prognosis
Proteins
Pulmonary Disease, Chronic Obstructive - diagnosis
Pulmonary Disease, Chronic Obstructive - epidemiology
Pulmonary Disease, Chronic Obstructive - physiopathology
Pulmonary function tests
Pulmonary Ventilation
Regression analysis
Risk Factors
Smoking
Smoking - adverse effects
Smoking - epidemiology
Spirometry
Surveys and Questionnaires
Up-Regulation
Uric acid
Uric Acid - blood
Weight Loss
Japan
airflow limitation
asthma
uric acid
health check-up
COPD
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The prevalence of COPD and asthma is increasing all over the world; however, their morbidities are thought to be greatly underestimated because of unawareness of patients' conditions and respiratory symptoms. Spirometry is useful for the early detection of COPD and asthma with airflow limitation (AL), although it is not yet widely used for screening in epidemiological and primary care settings. A simple predictive marker used in combination with spirometry for AL is expected to be established. In medical health check-ups, serum uric acid (s-UA) is measured when screening for gout and has recently been suggested to have an association with several respiratory disorders, including asthma and COPD. However, whether s-UA influences the development of AL remains unclear. Therefore, the aims of this study were to examine the relationship between AL and s-UA and to investigate s-UA as a potential auxiliary marker for predicting AL risk in medical health check-ups. A total of 8,662 subjects aged >40 years were included. They were administered a simple questionnaire and assessed using pulmonary function tests, blood pressure (BP) measurements, and blood samplings. One hundred and fifty-six subjects (1.8%) had AL, just 29% of whom had experienced respiratory symptoms. The subjects with AL had significantly higher s-UA levels compared with never-smoking subjects without AL. Forced expiratory volume in 1 second (FEV ) %predicted showed significant correlations with age, smoking index, body mass index (BMI), mean BP, white blood cells, hemoglobin A1c, s-UA, and high-density lipoprotein cholesterol. In multiple logistic regression analysis, s-UA, in addition to age, smoking index, respiratory symptoms, and BMI, was independently associated with AL. In conclusion, elevated s-UA levels, together with respiratory symptoms, high smoking index, and weight loss, may epidemiologically predict the development of AL risk.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1178-2005
1176-9106
1178-2005
DOI:10.2147/copd.s126249