Search Results - "Rinker, Sherri"

Self-assembled DNA nanostructures for distance-dependent multivalent ligand-protein binding by Liu, Yan, Chhabra, Rahul, Yan, Hao, Rinker, Sherri, Ke, Yonggang

“…An important goal of nanotechnology is to assemble multiple molecules while controlling the spacing between them. Of particular interest is the phenomenon of…”
Get full text

DNA Tile Based Self-Assembly: Building Complex Nanoarchitectures by Lin, Chenxiang, Liu, Yan, Rinker, Sherri, Yan, Hao

“…DNA tile based self‐assembly provides an attractive route to create nanoarchitectures of programmable patterns. It also offers excellent scaffolds for directed…”
Get full text

Spatially Addressable Multiprotein Nanoarrays Templated by Aptamer-Tagged DNA Nanoarchitectures by Chhabra, Rahul, Sharma, Jaswinder, Ke, Yonggang, Liu, Yan, Rinker, Sherri, Lindsay, Stuart, Yan, Hao

“…Here we generalize a highly programmable strategy to self-assemble multiprotein nanoarrays with deterministic positional addressability. These protein…”
Get full text

Sensitive assay design for detection of anti-drug antibodies to biotherapeutics that lack an immunoglobulin Fc domain by Johnson, Derrick, Simmons, Erica, Abdeen, Sanofar, Kinne, Adam, Parmer, Elijah, Rinker, Sherri, Thystrup, Jennifer, Ramaswamy, Swarna, Bowsher, Ronald R.

“…Today the evaluation of unwanted immunogenicity is a key component in the clinical safety evaluation of new biotherapeutic drugs and macromolecular delivery…”
Get full text

Phosphoethanolamine Transferase LptA in Haemophilus ducreyi Modifies Lipid A and Contributes to Human Defensin Resistance In Vitro by Trombley, Michael P, Post, Deborah M B, Rinker, Sherri D, Reinders, Lorri M, Fortney, Kate R, Zwickl, Beth W, Janowicz, Diane M, Baye, Fitsum M, Katz, Barry P, Spinola, Stanley M, Bauer, Margaret E

“…Haemophilus ducreyi resists the cytotoxic effects of human antimicrobial peptides (APs), including α-defensins, β-defensins, and the cathelicidin LL-37…”
Get full text

In vivo cloning of artificial DNA nanostructures by Lin, Chenxiang, Rinker, Sherri, Wang, Xing, Liu, Yan, Seeman, Nadrian C, Yan, Hao

“…Mimicking nature is both a key goal and a difficult challenge for the scientific enterprise. DNA, well known as the genetic-information carrier in nature, can…”
Get full text

Deletion of mtrC in Haemophilus ducreyi Increases Sensitivity to Human Antimicrobial Peptides and Activates the CpxRA Regulon by Rinker, Sherri D, Trombley, Michael P, Gu, Xiaoping, Fortney, Kate R, Bauer, Margaret E

“…Haemophilus ducreyi resists killing by antimicrobial peptides encountered during human infection, including cathelicidin LL-37, α-defensins, and β-defensins…”
Get full text

Haemophilus ducreyi SapA Contributes to Cathelicidin Resistance and Virulence in Humans by Mount, Kristy L.B, Townsend, Carisa A, Rinker, Sherri D, Gu, Xiaoping, Fortney, Kate R, Zwickl, Beth W, Janowicz, Diane M, Spinola, Stanley M, Katz, Barry P, Bauer, Margaret E

“…Haemophilus ducreyi is an extracellular pathogen of human epithelial surfaces that resists human antimicrobial peptides (APs). The organism's genome contains…”
Get full text

Permeases of the Sap Transporter Are Required for Cathelicidin Resistance and Virulence of Haemophilus ducreyi in Humans by Rinker, Sherri D., Gu, Xiaoping, Fortney, Kate R., Zwickl, Beth W., Katz, Barry P., Janowicz, Diane M., Spinola, Stanley M., Bauer, Margaret E.

“…Background. Haemophilus ducreyi encounters several classes of antimicrobial peptides (APs) in vivo and utilizes the sensitive-to-antimicrobial-peptides (Sap)…”
Get full text

DNA Self-assembly for Nanomedicine by Chhabra, Rahul, Sharma, Jaswinder, Liu, Yan, Rinker, Sherri, Yan, Hao

“…Self-assembling DNA nanostructures based on rationally designed DNA branch junction molecules has recently led to the construction of patterned supramolecular…”
Get full text

Assay development considerations to improve drug tolerance in direct competitive ligand binding neutralizing antibody assays, pretreatment strategies by Rathi, Alok, Rinker, Sherri, Niu, Hongmei, Carter, Carina, Kumar, Seema, Cowan, Kyra

“…Neutralizing anti-drug antibodies (ADAs) may affect safety, efficacy, and pharmacokinetic profile of a biotherapeutic drug and thus their assessment is of…”
Get full text

Critical reagent considerations for immunogenicity assay development for bispecific biotherapeutic candidates by Sinha, Arkadeep, Rinker, Sherri, Souliotis, Mallory Rose, Kumar, Rajesh, Kumar, Seema, Cowan, Kyra J

“…To demonstrate the importance of critical reagent characterization for immunogenicity assay development for multi-specific drugs using two case studies…”
Get more information

Noncompetitive immunoassay optimized for pharmacokinetic assessments of biologically active efruxifermin by Kinne, Adam S., Tillman, Erik J., Abdeen, Sanofar J., Johnson, Derrick E., Parmer, Elijah S., Hurst, Jacob P., de Temple, Brittany, Rinker, Sherri, Rolph, Timothy P., Bowsher, Ronald R.

“…Efruxifermin (EFX) is a homodimeric human IgG1 Fc-FGF21 fusion protein undergoing investigation for treatment of liver fibrosis due to nonalcoholic…”
Get full text

Two-dimensional LNA/DNA arrays: estimating the helicity of LNA/DNA hybrid duplex by Rinker, Sherri, Liu, Yan, Yan, Hao

“…We measured the helical repeats of a non-natural nucleic acid, locked nucleic acid (LNA), by incorporating LNA strands into the outer arms of a DNA double…”
Get more information

DNA Self-assembly for Nanomedicine: FROM BIOLOGY TO MATERIALS: ENGINEERING DNA AND RNA FOR DRUG DELIVERY AND NANOMEDICINE by CHHABRA, Rahul, SHARMA, Jaswinder, YAN LIU, RINKER, Sherri, HAO YAN

Get full text

Phosphoethanolamine Transferase LptA in Haemophilus ducreyi Modifies Lipid A and Contributes to Human Defensin Resistance In Vitro: e0124373 by Trombley, Michael P, Post, Deborah MB, Rinker, Sherri D, Reinders, Lorri M, tney, Kate R, Zwickl, Beth W, Janowicz, Diane M, Baye, Fitsum M, Katz, Barry P, Spinola, Stanley M

“…Haemophilus ducreyi resists the cytotoxic effects of human antimicrobial peptides (APs), including alpha -defensins, beta -defensins, and the cathelicidin…”
Get full text

DNA nanotechnology: Towards nanoscale construction of interactive biomolecular networks by Rinker, Sherri Diane

“…Nanotechnology is a burgeoning field as eager scientists are exploring every facet, driving toward a common goal of understanding the nanoscale world. DNA,…”
Get full text