Search Results - "Rinken, Ago"

Zeta Potential of Extracellular Vesicles: Toward Understanding the Attributes that Determine Colloidal Stability by Midekessa, Getnet, Godakumara, Kasun, Ord, James, Viil, Janeli, Lättekivi, Freddy, Dissanayake, Keerthie, Kopanchuk, Sergei, Rinken, Ago, Andronowska, Aneta, Bhattacharjee, Sourav, Rinken, Toonika, Fazeli, Alireza

“…Extracellular vesicles (EVs), including exosomes and microvesicles (<200 nm), play a vital role in intercellular communication and carry a net negative surface…”
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Intracellular dynamics of the Sigma-1 receptor observed with super-resolution imaging microscopy by Kopanchuk, Sergei, Vavers, Edijs, Veiksina, Santa, Ligi, Kadri, Zvejniece, Liga, Dambrova, Maija, Rinken, Ago

“…Sigma-1 receptor (Sig1R) is an endoplasmic reticulum (ER)-related membrane protein, that forms heteromers with other cellular proteins. As the mechanism of…”
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Image-based cell-size estimation for baculovirus quantification by Laasfeld, Tõnis, Kopanchuk, Sergei, Rinken, Ago

“…Measurement of virus concentration is essential for effective virus-based transfection technologies. Here, we describe a user-friendly, image-based cell-size…”
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Decidualized endometrial stromal cells present with altered androgen response in PCOS by Khatun, Masuma, Meltsov, Alvin, Lavogina, Darja, Loid, Marina, Kask, Keiu, Arffman, Riikka K., Rossi, Henna-Riikka, Lättekivi, Freddy, Jääger, Kersti, Krjutškov, Kaarel, Rinken, Ago, Salumets, Andres, Piltonen, Terhi T.

“…Hyperandrogenic women with PCOS show disrupted decidualization (DE) and placentation. Dihydrotestosterone (DHT) is reported to enhance DE in non-PCOS…”
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Microfluidic production, stability and loading of synthetic giant unilamellar vesicles by Ernits, Mart, Reinsalu, Olavi, Yandrapalli, Naresh, Kopanchuk, Sergei, Moradpur-Tari, Ehsan, Sanka, Immanuel, Scheler, Ott, Rinken, Ago, Kurg, Reet, Kyritsakis, Andreas, Linko, Veikko, Zadin, Veronika

“…In advanced drug delivery, versatile liposomal formulations are commonly employed for safer and more accurate therapies. Here we report a method that allows a…”
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ArtSeg—Artifact segmentation and removal in brightfield cell microscopy images without manual pixel-level annotations by Ali, Mohammed A. S., Hollo, Kaspar, Laasfeld, Tõnis, Torp, Jane, Tahk, Maris-Johanna, Rinken, Ago, Palo, Kaupo, Parts, Leopold, Fishman, Dmytro

“…Brightfield cell microscopy is a foundational tool in life sciences. The acquired images are prone to contain visual artifacts that hinder downstream analysis,…”
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Revisiting the Resazurin-Based Sensing of Cellular Viability: Widening the Application Horizon by Lavogina, Darja, Lust, Helen, Tahk, Maris-Johanna, Laasfeld, Tõnis, Vellama, Hans, Nasirova, Naila, Vardja, Markus, Eskla, Kattri-Liis, Salumets, Andres, Rinken, Ago, Jaal, Jana

“…Since 1991, the NAD(P)H-aided conversion of resazurin to fluorescent resorufin has been widely used to measure viability based on the metabolic activity in…”
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PL1 Peptide Engages Acidic Surfaces on Tumor-Associated Fibronectin and Tenascin Isoforms to Trigger Cellular Uptake by Lingasamy, Prakash, Põšnograjeva, Kristina, Kopanchuk, Sergei, Tobi, Allan, Rinken, Ago, General, Ignacio J, Asciutto, Eliana K, Teesalu, Tambet

“…Tumor extracellular matrix (ECM) is a high-capacity target for the precision delivery of affinity ligand-guided drugs and imaging agents. Recently, we…”
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Endocrine disrupting chemicals interfere with decidualization of human primary endometrial stromal cells in vitro by Lavogina, Darja, Visser, Nadja, Samuel, Külli, Davey, Eva, Björvang, Richelle D, Hassan, Jasmin, Koponen, Jani, Rantakokko, Panu, Kiviranta, Hannu, Rinken, Ago, Olovsson, Matts, Salumets, Andres, Damdimopoulou, Pauliina

“…Multiple studies have shown associations between exposure to endocrine disrupting chemicals (EDCs) and reduced fertility in women. However, little is known…”
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Chemoenzymatic synthesis and evaluation of 3-azabicyclo[3.2.0]heptane derivatives as dopaminergic ligands by Reinart-Okugbeni, Reet, Ausmees, Kerti, Kriis, Kadri, Werner, Franz, Rinken, Ago, Kanger, Tõnis

“…New 3-azabicyclo[3.2.0]heptane derivatives were synthesized using a multicomponent reaction. Racemic compounds were efficiently resolved by kinetic resolution…”
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Fluorescence based HTS-compatible ligand binding assays for dopamine D3 receptors in baculovirus preparations and live cells by Tahk, Maris-Johanna, Laasfeld, Tõnis, Meriste, Elo, Brea, Jose, Loza, Maria Isabel, Majellaro, Maria, Contino, Marialessandra, Sotelo, Eddy, Rinken, Ago

“…Dopamine receptors are G-protein-coupled receptors that are connected to severe neurological disorders. The development of new ligands targeting these…”
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Wfs1 is expressed in dopaminoceptive regions of the amniote brain and modulates levels of D1-like receptors by Tekko, Triin, Lakspere, Triin, Allikalt, Anni, End, Jaanus, Kõlvart, Karl Rene, Jagomäe, Toomas, Terasmaa, Anton, Philips, Mari-Anne, Visnapuu, Tanel, Väärtnõu, Fred, Gilbert, Scott F, Rinken, Ago, Vasar, Eero, Lilleväli, Kersti

“…During amniote evolution, the construction of the forebrain has diverged across different lineages, and accompanying the structural changes, functional…”
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Live-cell microscopy or fluorescence anisotropy with budded baculoviruses-which way to go with measuring ligand binding to M4 muscarinic receptors? by Tahk, Maris-Johanna, Torp, Jane, Ali, Mohammed A S, Fishman, Dmytro, Parts, Leopold, Grätz, Lukas, Müller, Christoph, Keller, Max, Veiksina, Santa, Laasfeld, Tõnis, Rinken, Ago

“…M4 muscarinic acetylcholine receptor is a G protein-coupled receptor (GPCR) that has been associated with alcohol and cocaine abuse, Alzheimer's disease, and…”
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Characterizing the bio-functionalization of gold surface with total internal reflection fluorescence (TIRF) microscopy by Ehrminger, Robin, Kopanchuk, Sergei, Kivirand, Kairi, Romann, Tavo, Rinken, Toonika, Min, Mart, Rinken, Ago

“…Quality of bioactive surface is crucial for achieving the required sensitivity and selectivity of biosensing systems. Numerous methods are available for the…”
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Modulation of Adenylyl Cyclase Activity in Rat Striatal Homogenate by Dopaminergic Receptors by Vonk, Argo, Reinart, Reet, Rinken, Ago

“…We have characterized the modulation of adenylyl cyclase (AC) activity by ligands of dopaminergic receptors in rat striatal homogenate and compared the results…”
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Modulation of dopamine D1 receptor signaling by adenosine A1 receptors in Sf9 cells requires expression of Gi proteins by UUSTARE, Ain, REINART, Reet, RINKEN, Ago

“…There are several evidences that some functions of D1 dopamine receptors can be modulated by colocalized adenosine A1 receptors. To elucidate the role of…”
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Characteristics of binding of [3H]WAY100635 to rat hippocampal membranes by Parkel, Sven, Rinken, Ago

“…Kinetic analysis of binding of [(3)H][N-[2-[4-(2-[O-methyl-(3)H]methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexane carboxamide ([(3)H]WAY100635) to…”
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Kinetic and functional properties of [3H]ZM241385, a high affinity antagonist for adenosine A2A receptors by Uustare, Ain, Vonk, Argo, Terasmaa, Anton, Fuxe, Kjell, Rinken, Ago

“…We have characterized the binding of [2-(3)H]-4-(2-[7-Amino-2-(2-furyl)-[1,2,4]-triazolo-[2,3-a]-[1,3,5]-triazin-5-ylamino]ethyl)phenol ([(3)H]ZM241385) to…”
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Assays with Detection of Fluorescence Anisotropy: Challenges and Possibilities for Characterizing Ligand Binding to GPCRs by Rinken, Ago, Lavogina, Darja, Kopanchuk, Sergei

“…Binding of fluorescent ligands (tracers) to their target receptors can be directly monitored over time, as the binding of a low-molecular-weight (LMW) tracer…”
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Effect of denervation of the locus coeruleus projections by DSP-4 treatment on [3H]-raclopride binding to dopamine D2 receptors and D2 receptor-G protein interaction in the rat striatum by HARRO, Jaanus, TERASMAA, Anton, ELLER, Marika, RINKEN, Ago

“…Changes in the control of dopaminergic neurotransmission by noradrenergic locus coeruleus (LC) projections has been implicated in such disorders as depression,…”
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