Search Results - "Rinkema, Lynn E"

Leukotriene receptor antagonists. 1. Synthesis and structure-activity relationships of alkoxyacetophenone derivatives by Marshall, Winston S, Goodson, Theodore, Cullinan, George J, Swanson-Bean, Dorothy, Haisch, Klaus D, Rinkema, Lynn E, Fleisch, Jerome H

“…A series of derivatives of 2,4-dihydroxy-3-propylacetophenone(1) were prepared and examined for their ability to block leukotriene D4 (LTD4) induced…”
Get full text

(Phenylmethoxy)phenyl derivatives of w-oxo- and w-tetrazolylalkanoic acids and related tetrazoles. Synthesis and evaluation as leukotriene D4 receptor antagonists by Dillard, Robert D, Hahn, Richard A, McCullough, Doris, Carr, F. Patrick, Rinkema, Lynn E, Roman, Carlos R, Fleisch, Jerome H

Get full text

Development of a series of phenyltetrazole leukotriene D4(LTD4) receptor antagonists by Harper, Richard W, Herron, David K, Bollinger, Nancy G, Sawyer, J. Scott, Baldwin, Ronald F, Roman, Carlos R, Rinkema, Lynn E, Fleisch, Jerome H

Get full text

Optimization of the quinoline and substituted benzyl moieties of a series of phenyltetrazole leukotriene D4 receptor antagonists by Sawyer, J. Scott, Baldwin, Ronald F, Rinkema, Lynn E, Roman, Carlos R, Fleisch, Jerome H

“…This report describes the development of a series of highly potent quinoline-based leukotriene D4 (LTD4) receptor antagonists containing an…”
Get full text

Leukotriene receptor antagonists. 2. The [[(tetrazol-5-ylaryl)oxy]methyl]acetophenone derivatives by Dillard, Robert D, Carr, F. Patrick, McCullough, Doris, Haisch, Klaus D, Rinkema, Lynn E, Fleisch, Jerome H

“…A series of [[(tetrazol-5-ylaryl)oxy]methyl]acetophenones was synthesized and evaluated as antagonists of leukotriene D4 induced contractions of guinea pig…”
Get full text

Leukotriene receptor antagonists. 4. Synthesis and leukotriene D4/E4 receptor antagonist activity of 4-(alkyl)acetophenone derivatives by Gapinski, D. Mark, Roman, Carlos R, Rinkema, Lynn E, Fleisch, Jerome H

“…Analogues of the leukotriene D4/E4 receptor antagonist LY171883 (1a) were synthesized in which the tetrazole was linked to the hydroxyacetophenone moiety by an…”
Get full text

Leukotriene receptor antagonism and augmentation of beta-receptor-mediated events by LY171883 by Rinkema, L E, Roman, C R, Russell, W L, Spaethe, S M, Bemis, K G, Henry, D P, Marshall, W S, Fleisch, J H

“…LY171883, (1-[2-hydroxy-3-propyl-4-[4(1H-tetrazol-5-yl)butoxy)phenyl]etha none), a leukotriene (LT) D4/E4 receptor antagonist, was assessed in comparison with…”
Get more information

Evidence for multiple leukotriene D4 receptors in smooth muscle by Fleisch, J H, Rinkema, L E, Baker, S R

“…Using pure leukotriene D4 (LTD4) as the agonist, we determined the dissociation constants, Kb and pA2 values, for the selective leukotriene antagonist FPL…”
Get more information

(Phenylmethoxy)phenyl derivatives of Ω-oxo- and Ω-tetrazolylalkanoic acids and related tetrazoles. Synthesis and evaluation as leukotriene D4 receptor antagonists by DILLARD, R. D, HAHN, R. A, MCCULLOUCH, D, CARR, F. P, RINKEMA, L. E, ROMAN, C. R, FLEISCH, J. H

“…Two series of (phenylmethoxy)phenyl compounds derived from the structure of LY163443 were synthesized and evaluated as leukotriene D4 receptor antagonists. In…”
Get full text

Pharmacologic receptors for the leukotrienes by Fleisch, J H, Rinkema, L E, Marshall, W S

Get more information

Contraction of guinea pig inferior vena cava by eicosanoids by RINKEMA, L. E, ROMAN, C. R, VANALSTYNE, E. L, SPAETHE, S. M, FLEISCH, J. H

“…Guinea pig inferior vena cava contracted in response to leukotriene (LT)C4, LTD4, LTE4 U46619, phenylephrine, histamine, and KCl. Although LTC4, LTD4, and…”
Get full text

Evaluation of LY163443, 1-[2-hydroxy-3-propyl-4-{[4-1H-tetrazol-5-methyl―phenoxy]methyl}phenyl]ethanone, as a pharmacologic antagonist of leukotrienes D4 and E4 by FLEISCH, J. H, RINKEMA, L. E, HAISCH, K. D, MCCULLOUGH, D, CARR, F. P, DILLARD, R. D

“…LY163443,1-[2-hydroxy-3-propyl-4-([4- (1H-tetrazol-5-ylmethyl)phenoxy]- phenoxy]methyl)phenyl]ethanone, antagonized LTD4-induced contractions of guinea pig…”
Get full text

Overdrive suppression of atrial pacemaker tissues in the alert, awake dog before and chronically after excision of the sinoatrial node by Randall, Walter C., Rinkema, Lynn E., Jones, Stephen B., Moran, John F., Brynjolfsson, Gissur

“…In characterizing pacemakers of the canine right atrium, cycle lengths after rapid atrial pacing were measured in the alert, conscious dog. Using implanted…”
Get full text

Effects of individual cardiac nerve stimulation on atrioventricular conduction by Rinkema, L E, Thomas, Jr, J X, Randall, W C

“…This study investigated the effects of individual canine cardiac nerve stimulation on atrioventricular conductions as measured by His bundle electrograms. A-H…”
Get more information