Search Results - "Ringuette, J."

Collagen IV trafficking: The inside-out and beyond story by Chioran, Alexa, Duncan, Sebastian, Catalano, Andrew, Brown, Theodore J., Ringuette, Maurice J.

“…Collagen IV networks endow basement membranes (BMs) with remarkable tensile strength and function as morphoregulatory substrata for diverse tissue-specific…”
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Summit of the N=40 island of inversion: Precision mass measurements and ab initio calculations of neutron-rich chromium isotopes by Silwal, R., Andreoiu, C., Ashrafkhani, B., Bergmann, J., Brunner, T., Cardona, J., Dietrich, K., Dunling, E., Gwinner, G., Hockenbery, Z., Holt, J.D., Izzo, C., Jacobs, A., Javaji, A., Kootte, B., Lan, Y., Lunney, D., Lykiardopoulou, E.M., Miyagi, T., Mougeot, M., Mukul, I., Murböck, T., Porter, W.S., Reiter, M., Ringuette, J., Dilling, J., Kwiatkowski, A.A.

“…Mass measurements continue to provide invaluable information for elucidating nuclear structure and scenarios of astrophysical interest. The transition region…”
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Ventricular Zone Expressed PH Domain Containing 1 (VEPH1): an adaptor protein capable of modulating multiple signaling transduction pathways during normal and pathological development by Brown, Theodore J, Kollara, Alexandra, Shathasivam, Premalatha, Ringuette, Maurice J

“…Ventricular Zone Expressed PH Domain-Containing 1 (VEPH1) is an 833-amino acid protein encoded by an evolutionarily conserved single-copy gene that emerged…”
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Human ortholog of Drosophila Melted impedes SMAD2 release from TGF-β receptor I to inhibit TGF-β signaling by Shathasivam, Premalatha, Kollara, Alexandra, Ringuette, Maurice J, Virtanen, Carl, Wrana, Jeffrey L, Brown, Theodore J

“…Drosophila melted encodes a pleckstrin homology (PH) domain-containing protein that enables normal tissue growth, metabolism, and photoreceptor differentiation…”
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Finite-span rotating wings: three-dimensional vortex formation and variations with aspect ratio by Carr, Z. R., Chen, C., Ringuette, M. J.

“…We investigate experimentally the effect of aspect ratio ( ) on the time-varying, three-dimensional flow structure of flat-plate wings rotating from rest at…”
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Loss of SPARC dysregulates basal lamina assembly to disrupt larval fat body homeostasis in Drosophila melanogaster by Shahab, Jaffer, Baratta, Cristina, Scuric, Bianca, Godt, Dorothea, Venken, Koen J.T., Ringuette, Maurice J.

“…Background: SPARC is a collagen‐binding glycoprotein whose functions during early development are unknown. We previously reported that SPARC is expressed in…”
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Slow binding kinetics of secreted protein, acidic, rich in cysteine‐VEGF interaction limit VEGF activation of VEGF receptor 2 and attenuate angiogenesis by Cydzik, Marzena, Abdul‐Wahid, Aws, Park, Soyeon, Bourdeau, Annie, Bowden, Katherine, Prodeus, Aaron, Kollara, Alexandra, Brown, Theodore J., Ringuette, Maurice J., Gariépy, Jean

“…VEGF‐A (VEGF) drives angiogenesis through activation of downstream effectors to promote endothelial cell proliferation and migration. Although VEGF binds both…”
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Collagen I but not Matrigel matrices provide an MMP-dependent barrier to ovarian cancer cell penetration by Sodek, Katharine L, Brown, Theodore J, Ringuette, Maurice J

“…The invasive potential of cancer cells is usually assessed in vitro using Matrigel as a surrogate basement membrane. Yet cancer cell interaction with collagen…”
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Dynamic distribution of nuclear coactivator 4 during mitosis: association with mitotic apparatus and midbodies by Kollara, Alexandra, Ringuette, Maurice J, Brown, Theodore J

“…The cytoplasmic localization of Nuclear Receptor Coactivator 4 (NcoA4), also referred to as androgen receptor associated protein 70 (ARA70), indicates it may…”
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Localization of the extracellular matrix protein SC1 to synapses in the adult rat brain by Lively, Starlee, Ringuette, Maurice J, Brown, Ian R

“…Extracellular matrix molecules play important roles in neural developmental processes such as axon guidance and synaptogenesis. When development is complete,…”
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The adaptor protein VEPH1 interacts with the kinase domain of ERBB2 and impacts EGF signaling in ovarian cancer cells by Kollara, Alexandra, Burt, Brian D., Ringuette, Maurice J., Brown, Theodore J.

“…Upregulation of ERBB2 and activating mutations in downstream KRAS/BRAF and PIK3CA are found in several ovarian cancer histotypes. ERBB2 enhances signaling by…”
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Compact spheroid formation by ovarian cancer cells is associated with contractile behavior and an invasive phenotype by Sodek, Katharine L., Ringuette, Maurice J., Brown, Theodore J.

“…Ovarian cancer cells are present in malignant ascites both as individual cells and as multicellular spheroid aggregates. Although spheroid formation affords…”
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Cell–cell and cell–matrix dynamics in intraperitoneal cancer metastasis by Sodek, Katharine L., Murphy, K. Joan, Brown, Theodore J., Ringuette, Maurice J.

“…The peritoneal metastatic route of cancer dissemination is shared by cancers of the ovary and gastrointestinal tract. Once initiated, peritoneal metastasis…”
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The predicted collagen-binding domains of Drosophila SPARC are essential for survival and for collagen IV distribution and assembly into basement membranes by Duncan, Sebastian, Delage, Samuel, Chioran, Alexa, Sirbu, Olga, Brown, Theodore J., Ringuette, Maurice J.

“…The assembly of basement membranes (BMs) into tissue-specific morphoregulatory structures requires non-core BM components. Work in Drosophila indicates a…”
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Increased androgen receptor levels and signaling in ovarian cancer cells by VEPH1 associated with suppression of SMAD3 and AKT activation by Kollara, Alexandra, Shathasivam, Premalatha, Park, Soyeon, Ringuette, Maurice J., Brown, Theodore J.

“…•VEPH1 increases androgen receptor levels and activity in ovarian cancer cells.•VEPH1 decreases SMAD3 levels and AKT activation in ovarian cancer cells.•AKT…”
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VEPH1 expression decreases vascularisation in ovarian cancer xenografts and inhibits VEGFA and IL8 expression through inhibition of AKT activation by Shathasivam, Premalatha, Kollara, Alexandra, Spybey, Thomasina, Park, Soyeon, Clarke, Blaise, Ringuette, Maurice J, Brown, Theodore J

“…Background: VEPH1 is amplified in several cancers including ovarian but its impact on tumour progression is unknown. Previous work has shown that VEPH1…”
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Vortex formation and saturation for low-aspect-ratio rotating flat-plate fins by DeVoria, Adam C., Ringuette, Matthew J.

“…We investigate experimentally the unsteady, three-dimensional vortex formation of low-aspect-ratio, trapezoidal flat-plate fins undergoing rotation from rest…”
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Identification of pathways associated with invasive behavior by ovarian cancer cells using multidimensional protein identification technology (MudPIT) by Sodek, Katharine L, Evangelou, Andreas I, Ignatchenko, Alex, Agochiya, Mahima, Brown, Theodore J, Ringuette, Maurice J, Jurisica, Igor, Kislinger, Thomas

“…Proteomic profiling has emerged as a useful tool for identifying tissue alterations in disease states including malignant transformation. The aim of this study…”
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Activation of SPARC Expression in Reactive Stroma Associated with Human Epithelial Ovarian Cancer by Brown, Theodore J., Shaw, Patricia A., Karp, Xantha, Huynh, My-Hang, Begley, Heather, Ringuette, Maurice J.

“…Objective. SPARC (secreted protein, acidic, rich in cysteine) is a calcium-binding counteradhesive glycoprotein that has the potential to play an important…”
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MT1-MMP is the critical determinant of matrix degradation and invasion by ovarian cancer cells by Sodek, K L, Ringuette, M J, Brown, T J

“…Membrane-type 1 matrix metalloproteinase (MT1-MMP), a transmembrane metalloprotease that plays an important role in the invasion of many solid tumour types,…”
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