Search Results - "Ringler, Anna"

Repair of UV-Induced DNA Damage Independent of Nucleotide Excision Repair Is Masked by MUTYH by Mazouzi, Abdelghani, Battistini, Federica, Moser, Sarah C., Ferreira da Silva, Joana, Wiedner, Marc, Owusu, Michel, Lardeau, Charles-Hugues, Ringler, Anna, Weil, Beatrix, Neesen, Jürgen, Orozco, Modesto, Kubicek, Stefan, Loizou, Joanna I.

“…DNA lesions caused by UV damage are thought to be repaired solely by the nucleotide excision repair (NER) pathway in human cells. Patients carrying mutations…”
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A combinatorial screen of the CLOUD uncovers a synergy targeting the androgen receptor by Licciardello, Marco P, Ringler, Anna, Markt, Patrick, Klepsch, Freya, Lardeau, Charles-Hugues, Sdelci, Sara, Schirghuber, Erika, Müller, André C, Caldera, Michael, Wagner, Anja, Herzog, Rebecca, Penz, Thomas, Schuster, Michael, Boidol, Bernd, Dürnberger, Gerhard, Folkvaljon, Yasin, Stattin, Pär, Ivanov, Vladimir, Colinge, Jacques, Bock, Christoph, Kratochwill, Klaus, Menche, Jörg, Bennett, Keiryn L, Kubicek, Stefan

“…The use of a refined chemical library called the CeMM library of unique drugs (CLOUD) identified a synergistic interaction between flutamide and phenprocoumon…”
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Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers by Schick, Sandra, Rendeiro, André F., Runggatscher, Kathrin, Ringler, Anna, Boidol, Bernd, Hinkel, Melanie, Májek, Peter, Vulliard, Loan, Penz, Thomas, Parapatics, Katja, Schmidl, Christian, Menche, Jörg, Boehmelt, Guido, Petronczki, Mark, Müller, André C., Bock, Christoph, Kubicek, Stefan

“…Aberrations in genes coding for subunits of the BRG1/BRM associated factor (BAF) chromatin remodeling complexes are highly abundant in human cancers…”
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MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation by Sdelci, Sara, Rendeiro, André F., Rathert, Philipp, You, Wanhui, Lin, Jung-Ming G., Ringler, Anna, Hofstätter, Gerald, Moll, Herwig P., Gürtl, Bettina, Farlik, Matthias, Schick, Sandra, Klepsch, Freya, Oldach, Matthew, Buphamalai, Pisanu, Schischlik, Fiorella, Májek, Peter, Parapatics, Katja, Schmidl, Christian, Schuster, Michael, Penz, Thomas, Buckley, Dennis L., Hudecz, Otto, Imre, Richard, Wang, Shuang-Yan, Maric, Hans Michael, Kralovics, Robert, Bennett, Keiryn L., Müller, Andre C., Mechtler, Karl, Menche, Jörg, Bradner, James E., Winter, Georg E., Klavins, Kristaps, Casanova, Emilio, Bock, Christoph, Zuber, Johannes, Kubicek, Stefan

“…The histone acetyl reader bromodomain-containing protein 4 (BRD4) is an important regulator of chromatin structure and transcription, yet factors modulating…”
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The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease by Kosack, Lindsay, Wingelhofer, Bettina, Popa, Alexandra, Orlova, Anna, Agerer, Benedikt, Vilagos, Bojan, Majek, Peter, Parapatics, Katja, Lercher, Alexander, Ringler, Anna, Klughammer, Johanna, Smyth, Mark, Khamina, Kseniya, Baazim, Hatoon, de Araujo, Elvin D., Rosa, David A., Park, Jisung, Tin, Gary, Ahmar, Siawash, Gunning, Patrick T., Bock, Christoph, Siddle, Hannah V., Woods, Gregory M., Kubicek, Stefan, Murchison, Elizabeth P., Bennett, Keiryn L., Moriggl, Richard, Bergthaler, Andreas

“…The marsupial Tasmanian devil (Sarcophilus harrisii) faces extinction due to transmissible devil facial tumor disease (DFTD). To unveil the molecular…”
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Global survey of the immunomodulatory potential of common drugs by Vladimer, Gregory I, Snijder, Berend, Krall, Nikolaus, Bigenzahn, Johannes W, Huber, Kilian V M, Lardeau, Charles-Hugues, Sanjiv, Kumar, Ringler, Anna, Berglund, Ulrika Warpman, Sabler, Monika, de la Fuente, Oscar Lopez, Knöbl, Paul, Kubicek, Stefan, Helleday, Thomas, Jäger, Ulrich, Superti-Furga, Giulio

“…A high-content screening platform that measures the immunological potential of small-molecule and biologic drugs by computationally determining changes in the…”
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CDK6 Antagonizes p53-Induced Responses during Tumorigenesis by Bellutti, Florian, Tigan, Anca-Sarmiza, Nebenfuehr, Sofie, Dolezal, Marlies, Zojer, Markus, Grausenburger, Reinhard, Hartenberger, Svenja, Kollmann, Sebastian, Doma, Eszter, Prchal-Murphy, Michaela, Uras, Iris Z, Höllein, Alexander, Neuberg, Donna S, Ebert, Benjamin L, Ringler, Anna, Mueller, Andre C, Loizou, Joanna I, Hinds, Philip W, Vogl, Claus, Heller, Gerwin, Kubicek, Stefan, Zuber, Johannes, Malumbres, Marcos, Farlik, Matthias, Villunger, Andreas, Kollmann, Karoline, Sexl, Veronika

“…Tumor formation is a multistep process during which cells acquire genetic and epigenetic changes until they reach a fully transformed state. We show that CDK6…”
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Combined chemosensitivity and chromatin profiling prioritizes drug combinations in CLL by Schmidl, Christian, Vladimer, Gregory I., Rendeiro, André F., Schnabl, Susanne, Krausgruber, Thomas, Taubert, Christina, Krall, Nikolaus, Pemovska, Tea, Araghi, Mohammad, Snijder, Berend, Hubmann, Rainer, Ringler, Anna, Runggatscher, Kathrin, Demirtas, Dita, de la Fuente, Oscar Lopez, Hilgarth, Martin, Skrabs, Cathrin, Porpaczy, Edit, Gruber, Michaela, Hoermann, Gregor, Kubicek, Stefan, Staber, Philipp B., Shehata, Medhat, Superti-Furga, Giulio, Jäger, Ulrich, Bock, Christoph

“…The Bruton tyrosine kinase (BTK) inhibitor ibrutinib has substantially improved therapeutic options for chronic lymphocytic leukemia (CLL). Although ibrutinib…”
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Image-based ex-vivo drug screening for patients with aggressive haematological malignancies: interim results from a single-arm, open-label, pilot study by Snijder, Berend, Vladimer, Gregory I, Krall, Nikolaus, Miura, Katsuhiro, Schmolke, Ann-Sofie, Kornauth, Christoph, Lopez de la Fuente, Oscar, Choi, Hye-Soo, van der Kouwe, Emiel, Gültekin, Sinan, Kazianka, Lukas, Bigenzahn, Johannes W, Hoermann, Gregor, Prutsch, Nicole, Merkel, Olaf, Ringler, Anna, Sabler, Monika, Jeryczynski, Georg, Mayerhoefer, Marius E, Simonitsch-Klupp, Ingrid, Ocko, Katharina, Felberbauer, Franz, Müllauer, Leonhard, Prager, Gerald W, Korkmaz, Belgin, Kenner, Lukas, Sperr, Wolfgang R, Kralovics, Robert, Gisslinger, Heinz, Valent, Peter, Kubicek, Stefan, Jäger, Ulrich, Staber, Philipp B, Superti-Furga, Giulio

“…Patients with refractory or relapsed haematological malignancies have few treatment options and short survival times. Identification of effective therapies…”
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5‐Arylidene‐2‐(4‐hydroxyphenyl)aminothiazol‐4(5H)‐ones with selective inhibitory activity against some leukemia cell lines by Subtelna, Ivanna, Kryshchyshyn‐Dylevych, Anna, Jia, Ruochen, Lelyukh, Maryan, Ringler, Anna, Kubicek, Stefan, Zagrijtschuk, Oleh, Kralovics, Robert, Lesyk, Roman

“…The data on the pharmacology of 4‐thiazolidinones showed that 5‐ene‐2‐(imino)amino‐4‐thiazolidinones are likely to comprise one of the most promising groups of…”
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Systematic characterization of BAF mutations provides insights into intra-complex synthetic lethalities in human cancers by Schick, Sandra, Rendeiro, André F., Runggatscher, Kathrin, Ringler, Anna, Boidol, Bernd, Hinkel, Melanie, Májek, Peter, Vulliard, Loan, Penz, Thomas, Parapatics, Katja, Schmidl, Christian, Menche, Jörg, Boehmelt, Guido, Petronczki, Mark, Mueller, André C., Bock, Christoph, Kubicek, Stefan

“…Aberrations in genes coding for subunits of the BAF chromatin remodeling complexes are highly abundant in human cancers. Currently, it is not understood how…”
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Integrated ATAC-Seq and Chemosensitivity Profiling Identifies Rational Drug Combinations in Ibrutinib-Treated CLL Patients by Vladimer, Gregory Ian, Schmidl, Christian, Renderio, Andre, Schnabl, Susanne, Pemovska, Tea, Snijder, Berend, Krausgruber, Thomas, Krall, Nikolaus, Araghi, Mohammad, Hubmann, Rainer, Ringler, Anna, Demirtas, Dita, Lopez de la Fuente, Oscar, Hilgrath, Martin, Skrabs, Cathrin, Porpaczy, Edit Anna, Gruber, Michaela, Hoermann, Gregor, Kubicek, Stefan, Staber, Philipp Bernhard, Shehata, Medhat M., Superti-Furga, Giulio, Bock, Christoph, Jaeger, Ulrich

“…▪ Chronic lymphocytic leukemia (CLL) is characterized by clonal proliferation and accumulation of malignant B lymphocytes in the blood, bone marrow, spleen,…”
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TKI rotation-induced persistent deep molecular response in multi-resistant blast crisis of Ph+ CML by Valent, Peter, Herndlhofer, Susanne, Schneeweiß, Mathias, Boidol, Bernd, Ringler, Anna, Kubicek, Stefan, Gleixner, Karoline V, Hoermann, Gregor, Hadzijusufovic, Emir, Müllauer, Leonhard, Sperr, Wolfgang R, Superti-Furga, Giulio, Mannhalter, Christine

“…In chronic myeloid leukemia (CML) resistance against one or more BCR-ABL1 tyrosine kinase inhibitors (TKI) remains a clinical challenge. Preclinical data…”
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Next-Generation Functional Drug Screening for Patients with Aggressive Hematologic Malignancies by Staber, Philipp Bernhard, Snijder, Berend, Vladimer, Gregory Ian, Krall, Nikolaus, Miura, Katsuhiro, Schmolke, Ann-Sofie, Kornauth, Christoph, Lopez de la Fuente, Oscar, Choi, Hye-Soo, van der Kouwe, Emiel, Kazianka, Lukas, Bigenzahn, Johannes, Hoermann, Gregor, Prutsch, Nicole, Merkel, Olaf, Ringler, Anna, Jeryczynski, Georg, Mayerhoefer, Marius, Simonitsch-Klupp, Ingrid, Felberbauer, Franz X, Muellauer, Leonhard, Prager, Gerald W, Korkmaz, Belgin, Kenner, Lukas, Sperr, Wolfgang R., Kralovics, Robert, Gisslinger, Heinz, Valent, Peter, Kubicek, Stefan, Jaeger, Ulrich, Superti-Furga, Giulio

“…Background. Patients with aggressive hematologic malignancies failing at least two lines of therapy are without further standard treatment options and have a…”
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