Search Results - "Rines, Amy K."

Insulin regulation of gluconeogenesis by Hatting, Maximilian, Tavares, Clint D.J., Sharabi, Kfir, Rines, Amy K., Puigserver, Pere

“…The coordinated regulation between cellular glucose uptake and endogenous glucose production is indispensable for the maintenance of constant blood glucose…”
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Targeting hepatic glucose metabolism in the treatment of type 2 diabetes by Rines, Amy K., Sharabi, Kfir, Tavares, Clint D. J., Puigserver, Pere

“…Key Points Type 2 diabetes is characterized by elevated blood glucose levels and insulin resistance. Current diabetes drugs can lower blood glucose but often…”
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Molecular pathophysiology of hepatic glucose production by Sharabi, Kfir, Tavares, Clint D.J., Rines, Amy K., Puigserver, Pere

“…Maintaining blood glucose concentration within a relatively narrow range through periods of fasting or excess nutrient availability is essential to the…”
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Transition metals and mitochondrial metabolism in the heart by Rines, Amy K, Ardehali, Hossein

“…Abstract Transition metals are essential to many biological processes in almost all organisms from bacteria to humans. Their versatility, which arises from an…”
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Adipose Tissue CLK2 Promotes Energy Expenditure during High-Fat Diet Intermittent Fasting by Hatting, Maximilian, Rines, Amy K., Luo, Chi, Tabata, Mitsuhisa, Sharabi, Kfir, Hall, Jessica A., Verdeguer, Francisco, Trautwein, Christian, Puigserver, Pere

“…A promising approach to treating obesity is to increase diet-induced thermogenesis in brown adipose tissue (BAT), but the regulation of this process remains…”
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Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling by Rines, Amy K., Chang, Hsiang-Chun, Wu, Rongxue, Sato, Tatsuya, Khechaduri, Arineh, Kouzu, Hidemichi, Shapiro, Jason, Shang, Meng, Burke, Michael A., Abdelwahid, Eltyeb, Jiang, Xinghang, Chen, Chunlei, Rawlings, Tenley A., Lopaschuk, Gary D., Schumacker, Paul T., Abel, E. Dale, Ardehali, Hossein

“…Ischaemic heart disease limits oxygen and metabolic substrate availability to the heart, resulting in tissue death. Here, we demonstrate that the AMP-activated…”
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Adenosine activates thermogenic adipocytes by Rines, Amy K, Verdeguer, Francisco, Puigserver, Pere

“…Brown or beige fat activation can cause potent anti-obesity and antidiabetic effects. In a study recently published in Nature, Gnad et aL show that adenosine…”
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Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes by Sharabi, Kfir, Lin, Hua, Tavares, Clint D.J., Dominy, John E., Camporez, Joao Paulo, Perry, Rachel J., Schilling, Roger, Rines, Amy K., Lee, Jaemin, Hickey, Marc, Bennion, Melissa, Palmer, Michelle, Nag, Partha P., Bittker, Joshua A., Perez, José, Jedrychowski, Mark P., Ozcan, Umut, Gygi, Steve P., Kamenecka, Theodore M., Shulman, Gerald I., Schreiber, Stuart L., Griffin, Patrick R., Puigserver, Pere

“…Type 2 diabetes (T2D) is a worldwide epidemic with a medical need for additional targeted therapies. Suppression of hepatic glucose production (HGP)…”
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A new pROM king for the mitoK(ATP) dance: ROMK takes the lead by Rines, Amy K, Bayeva, Marina, Ardehali, Hossein

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A New pROM King for the MitoKATP Dance: ROMK Takes the Lead by Rines, Amy K, Bayeva, Marina, Ardehali, Hossein

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Snf1‐related kinase inhibits colon cancer cell proliferation through calcyclin‐binding protein‐dependent reduction of β‐catenin by Rines, Amy K., Burke, Michael A., Fernandez, Richard P., Volpert, Olga V., Ardehali, Hossein

“…Sucrose nonfermenting 1 (Snf1)‐related kinase (SNRK) is a serine/threonine kinase with sequence similarity to AMP‐activated protein kinase (AMPK); however, its…”
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Corrigendum: Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling by Rines, Amy K, Chang, Hsiang-Chun, Wu, Rongxue, Sato, Tatsuya, Khechaduri, Arineh, Kouzu, Hidemichi, Shapiro, Jason, Shang, Meng, Burke, Michael A, Abdelwahid, Eltyeb, Jiang, Xinghang, Chen, Chunlei, Rawlings, Tenley A, Lopaschuk, Gary D, Schumacker, Paul T, Abel, E Dale, Ardehali, Hossein

“…This corrects the article DOI: 10.1038/ncomms14095…”
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Correction: Corrigendum: Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling by Rines, Amy K., Chang, Hsiang-Chun, Wu, Rongxue, Sato, Tatsuya, Khechaduri, Arineh, Kouzu, Hidemichi, Shapiro, Jason, Shang, Meng, Burke, Michael A., Abdelwahid, Eltyeb, Jiang, Xinghang, Chen, Chunlei, Rawlings, Tenley A., Lopaschuk, Gary D., Schumacker, Paul T., Abel, E. Dale, Ardehali, Hossein

“…Nature Communications 8: Article number: 14095 (2017); Published: 24 January 2017; Updated: 30 August 2017. The authors inadvertently omitted Eltyeb…”
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Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p by Bellare, Priya, Kutach, Alan K, Rines, Amy K, Guthrie, Christine, Sontheimer, Erik J

“…The U1, U2, U4/U6, and U5 small nuclear ribonucleoproteins (snRNPs) are components of the spliceosome, which catalyzes pre-mRNA splicing. One of the largest…”
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Phosphorylation of contractile proteins in response to α- and β-adrenergic stimulation in neonatal cardiomyocytes by Decker, Robert S, Rines, Amy K, Nakamura, Sakie, Naik, Tejaswitha J, Wassertsrom, J. Andrew, Ardehali, Hossein

“…α- and β-Adrenergic receptor agonists induce an inotropic response in the adult heart by promoting the phosphorylation of several regulatory proteins,…”
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A New pROM King for the MitoK ATP Dance: ROMK Takes the Lead by Rines, Amy K., Bayeva, Marina, Ardehali, Hossein

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Abstract 15687: Loss of Tribbles 3 (TRIB3) Attenuates Pressure-Overload Induced Myocardial Hypertrophy by Abdelwahid, Eltyeb, Wu, Rongxue, Rines, Amy K, Ardehali, Hossein

“…Abstract only Introduction: Tribbles 3 (TRIB3) is a pseudokinase that regulates several biological functions such as cell proliferation and differentiation…”
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Targeting hepatic glucose output in the treatment of type 2 diabetes by Rines, Amy K., Sharabi, Kfir, Tavares, Clint D. J., Puigserver, Pere

“…Type 2 diabetes mellitus is characterized by the dysregulation of glucose homeostasis resulting in hyperglycemia. Although current diabetes treatments have…”
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Abstract P238: Snf1-Related Kinase Is a Novel Regulator of Cardiomyocyte Metabolism by Rines, Amy K, Burke, Michael A, Nagpal, Varun, Ardehali, Hossein

“…Abstract only Background: Snf1-related Kinase (SNRK) is a serine/threonine kinase with sequence homology to AMP-activated kinase (AMPK). We have found that…”
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Abstract 12526: Snf1-related Kinase Improves Cardiac Mitochondrial Efficiency by Decreasing Mitochondrial Uncoupling by Rines, Amy K, Chang, Hsiang-Chun, Wu, Rongxue, Sato, Tatsuya, Khechaduri, Arineh, Shapiro, Jason S, Shang, Meng, Burke, Michael A, Jiang, Xinghang, Chen, Chunlei, Rawlings, Tenley A, Lopaschuk, Gary D, Schumacker, Paul T, Abel, E D, Ardehali, Hossein

“…IntroductionIschemic heart disease limits oxygen and metabolic substrate availability to the heart, resulting in cardiac tissue death. Snf1-related Kinase…”
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