Urinary desmosine as a biomarker in acute lung injury

Abstract Acute lung injury (ALI) is a complex disorder associated with an acute inflammatory response thought to contribute to tissue injury. Desmosine, a cross-linking amino acid present in elastin, is released during matrix degradation and cleared by the kidney. Results from animal models and huma...

Full description

Saved in:

Bibliographic Details
Published in:	Biomarkers Vol. 11; no. 1; pp. 85 - 96
Main Authors:	Fill, J. A., Brandt, J. T., Wiedemann, H. P., Rinehart, B. L., Lindemann, C. F., Komara, J. J., Bowsher, R. R., Spence, M. C., Zeiher, B. G.
Format:	Journal Article
Language:	English
Published:	London Informa UK Ltd 01-01-2006 Taylor & Francis
Subjects:	acute lung injury acute respiratory distress syndrome Aged Aged, 80 and over Biological and medical sciences Biomarkers - urine Desmosine Desmosine - urine Female Humans Male Medical sciences Middle Aged neutrophil elastase Pneumology Radioimmunoassay Reference Standards Reproducibility of Results Respiratory system : syndromes and miscellaneous diseases Human Leukocyte elastase Urine Lung disease Desmosine Serine endopeptidases Respiratory disease Enzyme Acute Biological marker acute lung injury Syndrome Peptidases neutrophil elastase acute respiratory distress syndrome Hydrolases Respiratory distress
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Abstract Acute lung injury (ALI) is a complex disorder associated with an acute inflammatory response thought to contribute to tissue injury. Desmosine, a cross-linking amino acid present in elastin, is released during matrix degradation and cleared by the kidney. Results from animal models and human disease studies have suggested that ALI is associated with the release of desmosine, resulting in increased urinary desmosine. A radioimmunoassay was used to monitor urinary desmosine levels over 10 days in ten patients with ALI. The concentration of desmosine was measured with and without acid hydrolysis. Baseline urinary desmosine was increased in two of ten patients. The concentration of desmosine at baseline did not appear to be related to age, gender, neutrophil elastase (NE)/ 1-antiprotease complex concentration or PaO2/FiO2 ratio. No meaningful changes in desmosine levels were noted after removal from mechanical ventilation. Baseline desmosine concentrations did not appear to correlate with the risk of death. The limited sensitivity, predictive correlations and dynamic modulation would suggest that urine desmosine has a limited role as a biomarker for ALI. Hydrolysis of urine samples appears necessary for optimal measurement of urine desmosine.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1354-750X 1366-5804
DOI:	10.1080/13547500500343225