Search Results - "Rindgen, D"

The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents by Hutson, P H, Finger, E N, Magliaro, B C, Smith, S M, Converso, A, Sanderson, P E, Mullins, D, Hyde, L A, Eschle, B K, Turnbull, Z, Sloan, H, Guzzi, M, Zhang, X, Wang, A, Rindgen, D, Mazzola, R, Vivian, J A, Eddins, D, Uslaner, J M, Bednar, R, Gambone, C, Le-Mair, W, Marino, M J, Sachs, N, Xu, G, Parmentier-Batteur, S

“…Inhibition of phosphodiesterase 9 (PDE9) has been reported to enhance rodent cognitive function and may represent a potential novel approach to improving…”
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Systematic LC/MS metabolite identification in drug discovery by Clarke, N J, Rindgen, D, Korfmacher, W A, Cox, K A

“…Clarke et al present the choices and decisions involved in metabolite identification and how they can be merged into a systematic approach. The discussion…”
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Formation of a substituted 1,N(6)-etheno-2'-deoxyadenosine adduct by lipid hydroperoxide-mediated generation of 4-oxo-2-nonenal by Rindgen, D, Lee, S H, Nakajima, M, Blair, I A

“…Analysis of the reaction between 2'-deoxyadenosine and 13-hydroperoxylinoleic acid by liquid chromatography/constant neutral loss mass spectrometry revealed…”
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Covalent Modifications to 2‘-Deoxyguanosine by 4-Oxo-2-nonenal, a Novel Product of Lipid Peroxidation by Rindgen, Diane, Nakajima, Masaharu, Wehrli, Suzanne, Xu, Keyang, Blair, Ian A

“…Two major products (adducts A and B) from the reaction of 2‘-deoxyguanosine (dGuo) with 13-hydroperoxylinoleic acid were detected by liquid chromatography/mass…”
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The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(t e trahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4- o n e) enhances synaptic plasticity and cognitive function in rodents by Hutson, PH, Finger, EN, Magliaro, B C, Smith, S M, Converso, A, Sanderson, P E, Mullins, D, Hyde, LA, Eschle, B K, Turnbull, Z, Sloan, H, Guzzi, M, Zhang, X, Wang, A, Rindgen, D, Mazzola, R, Vivian, JA, Eddins, D, Uslaner, J M, Bednar, R, Gambone, C, Le-Mair, W, Marino, MJ, Sachs, N, Xu, G, Parmentier-Batteur, S

“…Inhibition of phosphodiesterase 9 (PDE9) has been reported to enhance rodent cognitive function and may represent a potential novel approach to improving…”
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The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3 S,4 S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2 H-pyran-4-yl)-1,5-dihydro-4 H-pyrazolo[3,4- d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents by Hutson, P.H., Finger, E.N., Magliaro, B.C., Smith, S.M., Converso, A., Sanderson, P.E., Mullins, D., Hyde, L.A., Eschle, B.K., Turnbull, Z., Sloan, H., Guzzi, M., Zhang, X., Wang, A., Rindgen, D., Mazzola, R., Vivian, J.A., Eddins, D., Uslaner, J.M., Bednar, R., Gambone, C., Le-Mair, W., Marino, M.J., Sachs, N., Xu, G., Parmentier-Batteur, S.

“…Inhibition of phosphodiesterase 9 (PDE9) has been reported to enhance rodent cognitive function and may represent a potential novel approach to improving…”
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Characterization of 2‘-Deoxyadenosine Adducts Derived from 4-Oxo-2-nonenal, a Novel Product of Lipid Peroxidation by Lee, Seon Hwa, Rindgen, Diane, Bible, Roy H, Hajdu, Elisabeth, Blair, Ian A

“…Analysis of the reaction between 2‘-deoxyadenosine and 4-oxo-2-nonenal by liquid chromatography/mass spectrometry revealed the presence of three major products…”
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Synthesis and Characterization of Polycyclic Aromatic Hydrocarbon o-Quinone Depurinating N7-Guanine Adducts by McCoull, Kirsten D, Rindgen, Diane, Blair, Ian A, Penning, Trevor M

“…Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants which may cause cancer and require metabolic activation to exert their carcinogenic…”
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Formation of a Substituted 1,N 6-Etheno-2‘-deoxyadenosine Adduct by Lipid Hydroperoxide-Mediated Generation of 4-Oxo-2-nonenal by Rindgen, Diane, Lee, Seon Hwa, Nakajima, Masaharu, Blair, Ian A

“…Analysis of the reaction between 2‘-deoxyadenosine and 13-hydroperoxylinoleic acid by liquid chromatography/constant neutral loss mass spectrometry revealed…”
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Determination of in Vitro Formed DNA Adducts of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine Using Capillary Liquid Chromatography/Electrospray Ionization/Tandem Mass Spectrometry by Rindgen, Diane, Turesky, Robert J, Vouros, Paul

“…On-line reversed-phase capillary liquid chromatography/tandem mass spectrometry with electrospray ionization was used for the detection of…”
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Formation of a Substituted 1,N super(6)-Etheno-2'-deoxyadenosine Adduct by Lipid Hydroperoxide-Mediated Generation of 4-Oxo-2-nonenal by Rindgen, D, Lee, Seon Hwa, Nakajima, M, Blair, IA

“…Analysis of the reaction between 2'-deoxyadenosine and 13-hydroperoxylinoleic acid by liquid chromatography/constant neutral loss mass spectrometry revealed…”
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Isolation of circulating metabolites in drug discovery using high-performance liquid chromatography, and their identification by liquid chromatography coupled with tandem mass spectrometry and nuclear magnetic resonance spectroscopy by Kim, Hong, Feng, Wenqing, Chan, Tze-Ming, Rindgen, Diane, Bryant, Matthew, Cox, Kathleen A., Xia, Yan, Reichard, Gregory, Paliwal, Sunil, Hesk, David, Palamanda, Jairam, White, Ronald E., Nomeir, Amin A.

“…One of the major components of modern drug discovery is the structural determination and the assessment of biological activity of plasma metabolites. LC‐MS/MS…”
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Mass spectrometric assay for determination of pancuronium and vecuronium in biological fluids utilizing the moving belt introduction system by Baker, T R, Vouros, P, Rindgen, D, Martyn, J A

“…An assay for the determination of the neuromuscular blocking agents pancuronium bromide and vecuronium bromide in plasma or urine has been developed. This…”
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