Search Results - "Rinauro, Dillon J."

Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases by Rinauro, Dillon J, Chiti, Fabrizio, Vendruscolo, Michele, Limbocker, Ryan

“…The conversion of native peptides and proteins into amyloid aggregates is a hallmark of over 50 human disorders, including Alzheimer's and Parkinson's…”
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A Structural Ensemble of a Tau-Microtubule Complex Reveals Regulatory Tau Phosphorylation and Acetylation Mechanisms by Brotzakis, Z. Faidon, Lindstedt, Philip R, Taylor, Ross J, Rinauro, Dillon J, Gallagher, Nicholas C. T, Bernardes, Gonçalo J. L, Vendruscolo, Michele

“…Tau is a microtubule-associated protein that regulates the stability of microtubules. We use metainference cryoelectron microscopy, an integrative structural…”
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Nonhuman IAPP Variants Inhibit Human IAPP Aggregation by Oakes, Alissa, Menefee, Kate, Lamba, Arleen, Palato, Larry M, Rinauro, Dillon J, Tun, Angela, Jauregui, Betssy, Chang, Kevin, Nogaj, Luiza A, Moffet, David A

“…To identify naturally occurring variants of IAPP capable of inhibiting the aggregation of human IAPP and protecting living cells from the toxic effects of…”
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Varied mechanisms for the neutralization of biological toxins using natural products by Limbocker, Ryan, Gabriel, Justus, Tan, Thomas, Rinauro, Dillon J., Vendruscolo, Michele

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Secondary Processes Dominate the Quiescent, Spontaneous Aggregation of α‑Synuclein at Physiological pH with Sodium Salts by Horne, Robert I., Man, Wing, Rinauro, Dillon J., Brotzakis, Z. Faidon, Chia, Sean, Meisl, Georg, Vendruscolo, Michele

“…The accurate recapitulation in an in vitro assay of the aggregation process of α-synuclein in Parkinson’s disease has been a significant challenge. As…”
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EGCG inactivates a pore-forming toxin by promoting its oligomerization and decreasing its solvent-exposed hydrophobicity by Gabriel, Justus M., Tan, Thomas, Rinauro, Dillon J., Hsu, Claire M., Buettner, Caleb J., Gilmer, Marshall, Kaur, Amrita, McKenzie, Tristan L., Park, Martin, Cohen, Sophie, Errico, Silvia, Wright, Aidan K., Chiti, Fabrizio, Vendruscolo, Michele, Limbocker, Ryan

“…Natural proteinaceous pore-forming agents can bind and permeabilize cell membranes, leading to ion dyshomeostasis and cell death. In the search for antidotes…”
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A Brain-Permeable Aminosterol Regulates Cell Membranes to Mitigate the Toxicity of Diverse Pore-Forming Agents by Kreiser, Ryan P, Wright, Aidan K, Sasser, Liam R, Rinauro, Dillon J, Gabriel, Justus M, Hsu, Claire M, Hurtado, Jorge A, McKenzie, Tristan L, Errico, Silvia, Albright, J. Alex, Richardson, Lance, Jaffett, Victor A, Riegner, Dawn E, Nguyen, Lam T, LeForte, Kathleen, Zasloff, Michael, Hollows, Jared E, Chiti, Fabrizio, Vendruscolo, Michele, Limbocker, Ryan

“…The molecular composition of the plasma membrane plays a key role in mediating the susceptibility of cells to perturbations induced by toxic molecules. The…”
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Amyloidogenicity of naturally occurring full‐length animal IAPP variants by Palato, Larry M., Pilcher, Shannon, Oakes, Alissa, Lamba, Arleen, Torres, Jaris, Ledesma Monjaraz, Litza I., Munoz, Crystabel, Njoo, Edward, Rinauro, Dillon J., Menefee, Kate Alexandra, Tun, Angela, Jauregui, Betssy L., Shapiro, Sarah, Nossiff, Olivia H., Olivares, Eileen, Chang, Kevin, Nguyen, Viviane, Nogaj, Luiza A., Moffet, David A.

“…The aggregation of the 37‐amino acid polypeptide human islet amyloid polypeptide (hIAPP), as either insoluble amyloid or as small oligomers, appears to play a…”
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Kinetic analysis of tau aggregation for drug discovery by Rinauro, Dillon J., Vendruscolo, Michele

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Small molecule and antibody mediated inhibition of the aggregation of a tau fragment implicit in Alzheimer's disease by McKenzie, Tristan L., Kreiser, Ryan P., Limbocker, Ryan A., Rinauro, Dillon J., Vendruscolo, Michele

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The aggregation kinetics of α-Synuclein at neutral pH under quiescent conditions by Man, Wing K., Metrick, Michael A., Rinauro, Dillon J., Vendruscolo, Michele

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Modulators of the plasma membrane protect cells from diverse toxic agents, ranging from protein misfolded oligomers to pore forming agents by Limbocker, Ryan, Kreiser, Ryan P., Sasser, Liam R., Wright, Aidan K., Rinauro, Dillon J., Vendruscolo, Michele

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