Search Results - "Rinaldi, Silvia"

Disulfide Bond Mimetics: Strategies and Challenges by Gori, Alessandro, Gagni, Paola, Rinaldi, Silvia

“…The activity profile of many biologically relevant proteins and peptides often relies on a precise 3D structural organization. In this context, disulfide bonds…”
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Allosteric Modulators of HSP90 and HSP70: Dynamics Meets Function through Structure-Based Drug Design by Ferraro, Mariarosaria, D’Annessa, Ilda, Moroni, Elisabetta, Morra, Giulia, Paladino, Antonella, Rinaldi, Silvia, Compostella, Federica, Colombo, Giorgio

“…Molecular chaperones HSP90 and HSP70 are essential regulators of the folding and activation of a disparate ensemble of client proteins. They function through…”
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Another side of the association between body mass index (BMI) and clinical outcomes of cancer patients receiving programmed cell death protein-1 (PD-1)/ Programmed cell death-ligand 1 (PD-L1) checkpoint inhibitors: A multicentre analysis of immune-related adverse events by Cortellini, Alessio, Bersanelli, Melissa, Santini, Daniele, Buti, Sebastiano, Tiseo, Marcello, Cannita, Katia, Perrone, Fabiana, Giusti, Raffaele, De Tursi, Michele, Zoratto, Federica, Marconcini, Riccardo, Russano, Marco, Zeppola, Tea, Anesi, Cecilia, Filetti, Marco, Marchetti, Paolo, Botticelli, Andrea, Gelibter, Alain, De Galitiis, Federica, Vitale, Maria Giuseppa, Rastelli, Francesca, Tudini, Marianna, Silva, Rosa Rita, Atzori, Francesco, Chiari, Rita, Ricciuti, Biagio, De Giglio, Andrea, Migliorino, Maria Rita, Mallardo, Domenico, Vanella, Vito, Mosillo, Claudia, Bracarda, Sergio, Rinaldi, Silvia, Berardi, Rossana, Natoli, Clara, Ficorella, Corrado, Porzio, Giampiero, Ascierto, Paolo A.

“…Several studies have found an association between higher body mass index (BMI) and improved clinical outcomes in cancer patients receiving programmed cell…”
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A multicenter study of body mass index in cancer patients treated with anti-PD-1/PD-L1 immune checkpoint inhibitors: when overweight becomes favorable by Cortellini, Alessio, Bersanelli, Melissa, Buti, Sebastiano, Cannita, Katia, Santini, Daniele, Perrone, Fabiana, Giusti, Raffaele, Tiseo, Marcello, Michiara, Maria, Di Marino, Pietro, Tinari, Nicola, De Tursi, Michele, Zoratto, Federica, Veltri, Enzo, Marconcini, Riccardo, Malorgio, Francesco, Russano, Marco, Anesi, Cecilia, Zeppola, Tea, Filetti, Marco, Marchetti, Paolo, Botticelli, Andrea, Antonini Cappellini, Gian Carlo, De Galitiis, Federica, Vitale, Maria Giuseppa, Rastelli, Francesca, Pergolesi, Federica, Berardi, Rossana, Rinaldi, Silvia, Tudini, Marianna, Silva, Rosa Rita, Pireddu, Annagrazia, Atzori, Francesco, Chiari, Rita, Ricciuti, Biagio, De Giglio, Andrea, Iacono, Daniela, Gelibter, Alain, Occhipinti, Mario Alberto, Parisi, Alessandro, Porzio, Giampiero, Fargnoli, Maria Concetta, Ascierto, Paolo Antonio, Ficorella, Corrado, Natoli, Clara

“…Recent evidence suggested a potential correlation between overweight and the efficacy of immune checkpoint inhibitors (ICIs) in cancer patients. We conducted a…”
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Comparison of the isomerization mechanisms of human melanopsin and invertebrate and vertebrate rhodopsins by Rinaldi, Silvia, Melaccio, Federico, Gozem, Samer, Fanelli, Francesca, Olivucci, Massimo

“…Comparative modeling and ab initio multiconfigurational quantum chemistry are combined to investigate the reactivity of the human nonvisual photoreceptor…”
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Label-Free SERS and MD Analysis of Biomarkers for Rapid Point-of-Care Sensors Detecting Head and Neck Cancer and Infections by Farnesi, Edoardo, Rinaldi, Silvia, Liu, Chen, Ballmaier, Jonas, Guntinas-Lichius, Orlando, Schmitt, Michael, Cialla-May, Dana, Popp, Juergen

“…For the progress of point-of-care medicine, where individual health status can be easily and quickly monitored using a handheld sensor, saliva serves as one of…”
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Molecular bases for the selection of the chromophore of animal rhodopsins by Luk, Hoi Ling, Melaccio, Federico, Rinaldi, Silvia, Gozem, Samer, Olivucci, Massimo

“…The functions of microbial and animal rhodopsins are triggered by the isomerization of their all-transand 11-cisretinal chromophores, respectively. To lay the…”
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Correlations Between the Immune-related Adverse Events Spectrum and Efficacy of Anti-PD1 Immunotherapy in NSCLC Patients by Cortellini, Alessio, Chiari, Rita, Ricciuti, Biagio, Metro, Giulio, Perrone, Fabiana, Tiseo, Marcello, Bersanelli, Melissa, Bordi, Paola, Santini, Daniele, Giusti, Raffaele, Grassadonia, Antonino, Di Marino, Pietro, Tinari, Nicola, De Tursi, Michele, Zoratto, Federica, Veltri, Enzo, Malorgio, Francesco, Garufi, Carlo, Russano, Marco, Anesi, Cecilia, Zeppola, Tea, Filetti, Marco, Marchetti, Paolo, Berardi, Rossana, Rinaldi, Silvia, Tudini, Marianna, Silva, Rosa Rita, Pireddu, Annagrazia, Atzori, Francesco, Iacono, Daniela, Migliorino, Maria Rita, Porzio, Giampiero, Cannita, Katia, Ficorella, Corrado, Buti, Sebastiano

“…Immune-related adverse events (irAEs) developed during immunotherapy with anti-PD-1 agents, could be a predictive surrogate marker of clinical benefit in…”
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SARS-CoV-2 inhibitory activity of a short peptide derived from internal fusion peptide of S2 subunit of spike glycoprotein by Stincarelli, Maria Alfreda, Quagliata, Michael, Di Santo, Andrea, Pacini, Lorenzo, Fernandez, Feliciana Real, Arvia, Rosaria, Rinaldi, Silvia, Papini, Anna Maria, Rovero, Paolo, Giannecchini, Simone

“…•Peptides designed on internal fusion peptide region of S2 subunit of Spike SARS-CoV-2.•High inhibitory activity of a short PN19 peptide from internal fusion…”
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Toward Automatic Rhodopsin Modeling as a Tool for High-Throughput Computational Photobiology by Melaccio, Federico, del Carmen Marín, María, Valentini, Alessio, Montisci, Fabio, Rinaldi, Silvia, Cherubini, Marco, Yang, Xuchun, Kato, Yoshitaka, Stenrup, Michael, Orozco-Gonzalez, Yoelvis, Ferré, Nicolas, Luk, Hoi Ling, Kandori, Hideki, Olivucci, Massimo

“…We report on a prototype protocol for the automatic and fast construction of congruous sets of QM/MM models of rhodopsin-like photoreceptors and of their…”
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Exudative perifoveal vascular anomalous complex (ePVAC) resembling lesion in a patient with adult-onset foveomacular vitelliform dystrophy by Milan, Serena, Pastore, Marco Rocco, Gaggino, Andrea, Rinaldi, Silvia, Tognetto, Daniele

“…to report a case of exudative perifoveal vascular anomalous complex (ePVAC) in a patient with adult-onset foveomacular vitelliform dystrophy. A 71-year-old…”
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Hyponatremia in cancer patients: time for a new approach by Rossana, Berardi, Silvia, Rinaldi, Miriam, Caramanti, Christian, Grohè, Matteo, Santoni, Francesca, Morgese, Mariangela, Torniai, Agnese, Savini, Ilaria, Fiordoliva, Stefano, Cascinu

“…Highlights • Hyponatremia is relevant in cancer patients because it may have a negative impact on outcome, on quality of life and on length of hospitalization…”
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Risk of Hyponatraemia in Cancer Patients Treated with Targeted Therapies: A Systematic Review and Meta-Analysis of Clinical Trials by Berardi, Rossana, Santoni, Matteo, Rinaldi, Silvia, Nunzi, Emilia, Smerilli, Alessia, Caramanti, Miriam, Morgese, Francesca, Torniai, Mariangela, Savini, Agnese, Fiordoliva, Ilaria, Onofri, Azzurra, Pistelli, Mirco, Taccaliti, Augusto, Cascinu, Stefano

“…Hyponatraemia has been reported with targeted therapies in cancer patients. Aim of the study was to perform an up-to-date meta-analysis in order to determine…”
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Setup and Validation of a Reliable Docking Protocol for the Development of Neuroprotective Agents by Targeting the Sigma-1 Receptor (S1R) by Rossino, Giacomo, Rui, Marta, Pozzetti, Luca, Schepmann, Dirk, Wünsch, Bernhard, Zampieri, Daniele, Pellavio, Giorgia, Laforenza, Umberto, Rinaldi, Silvia, Colombo, Giorgio, Morelli, Laura, Linciano, Pasquale, Rossi, Daniela, Collina, Simona

“…Sigma-1 receptor (S1R) is a promising molecular target for the development of novel effective therapies against neurodegenerative diseases. To speed up the…”
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A Local Allosteric Network in Heat Shock Protein 70 (Hsp70) Links Inhibitor Binding to Enzyme Activity and Distal Protein–Protein Interactions by Rinaldi, Silvia, Assimon, Victoria A, Young, Zapporah T, Morra, Giulia, Shao, Hao, Taylor, Isabelle R, Gestwicki, Jason E, Colombo, Giorgio

“…Allosteric inhibitors can be more difficult to optimize without an understanding of how their binding influences the conformational motions of the target…”
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Gastrointestinal neuroendocrine tumors: Searching the optimal treatment strategy—A literature review by Berardi, Rossana, Rinaldi, Silvia, Torniai, Mariangela, Morgese, Francesca, Partelli, Stefano, Caramanti, Miriam, Onofri, Azzurra, Polenta, Vanessa, Pagliaretta, Silvia, Falconi, Massimo, Cascinu, Stefano

“…Highlights • Neuroendocrine tumors of the gastro-entero-pancreatic system (GEP-NETs) are a heterogeneous group of neoplasms, with different behavior. • A…”
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High Prevalence and Early Occurrence of Skeletal Complications in EGFR Mutated NSCLC Patients With Bone Metastases by Laganà, Marta, Gurizzan, Cristina, Roca, Elisa, Cortinovis, Diego, Signorelli, Diego, Pagani, Filippo, Bettini, Anna, Bonomi, Lucia, Rinaldi, Silvia, Berardi, Rossana, Filetti, Marco, Giusti, Raffaele, Pilotto, Sara, Milella, Michele, Intagliata, Salvatore, Baggi, Alice, Cortellini, Alessio, Soto Parra, Hector, Brighenti, Matteo, Petrelli, Fausto, Bennati, Chiara, Bidoli, Paolo, Garassino, Marina Chiara, Berruti, Alfredo

“…The prevalence of Skeletal Related Adverse Events (SREs) in EGFR mutated non-small cell lung cancer (NSCLC) patients with bone metastases, treated with modern…”
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Managing hyponatremia in lung cancer: latest evidence and clinical implications by Fiordoliva, Ilaria, Meletani, Tania, Baleani, Maria Giuditta, Rinaldi, Silvia, Savini, Agnese, Di Pietro Paolo, Marzia, Berardi, Rossana

“…Hyponatremia is the most common electrolyte disorder in lung cancer patients. This condition may be related to many causes including incidental medications,…”
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Axis I and II Disorders and Quality of Life in Bariatric Surgery Candidates by MAURI, Mauro, RUCCI, Paola, CASSANO, Giovanni B, CALDERONE, Alba, SANTINI, Ferruccio, OPPO, Annalisa, ROMANO, Anna, RINALDI, Silvia, ARMANI, Antonella, POLINI, Margherita, PINCHERA, Aldo

“…This study examined the prevalence of Axis I and II psychopathology and its relationship with quality of life in candidates for bariatric surgery. Consecutive…”
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Systemic treatment for lung carcinoids: from bench to bedside by Torniai, Mariangela, Scortichini, Laura, Tronconi, Francesca, Rubini, Corrado, Morgese, Francesca, Rinaldi, Silvia, Mazzanti, Paola, Berardi, Rossana

“…In the huge spectrum of lung neuroendocrine neoplasms, typical and atypical carcinoids should be considered as a separate biological entity from poorly…”
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