Search Results - "Rinaldi, Lucrezia"
-
1
Low Affinity Binding Site Clusters Confer Hox Specificity and Regulatory Robustness
Published in Cell (15-01-2015)“…In animals, Hox transcription factors define regional identity in distinct anatomical domains. How Hox genes encode this specificity is a paradox, because…”
Get full text
Journal Article -
2
Targeted systematic evolution of an RNA platform neutralizing DNMT1 function and controlling DNA methylation
Published in Nature communications (06-01-2023)“…DNA methylation is a fundamental epigenetic modification regulating gene expression. Aberrant DNA methylation is the most common molecular lesion in cancer…”
Get full text
Journal Article -
3
HOXB8 Counteracts MAPK/ERK Oncogenic Signaling in a Chicken Embryo Model of Neoplasia
Published in International journal of molecular sciences (18-08-2021)“…HOX transcription factors are members of an evolutionarily conserved family of proteins required for the establishment of the anteroposterior body axis during…”
Get full text
Journal Article -
4
NAD Modulates DNA Methylation and Cell Differentiation
Published in Cells (Basel, Switzerland) (02-11-2021)“…Nutritional intake impacts the human epigenome by directing epigenetic pathways in normal cell development via as yet unknown molecular mechanisms…”
Get full text
Journal Article -
5
HoxB genes regulate neuronal delamination in the trunk neural tube by controlling the expression of Lzts1
Published in Development (Cambridge) (18-02-2021)“…Differential Hox gene expression is central for specification of axial neuronal diversity in the spinal cord. Here, we uncover an additional function of Hox…”
Get full text
Journal Article -
6
Fattening the perspective of Hox protein specificity through SLiMming
Published in The International journal of developmental biology (2018)“…The functional identification and dissection of protein domains has been a successful approach towards the understanding of Hox protein specificity. However,…”
Get full text
Journal Article