Search Results - "Rimoldi, Donata"

Toll-like Receptor 3 Expressed by Melanoma Cells as a Target for Therapy? by SALAUN, Bruno, LEBECQUE, Serge, MATIKAINEN, Sampsa, RIMOLDI, Donata, ROMERO, Pedro

“…Purpose: The immunomodulatory properties of Toll-like receptors (TLR) agonists have inspired their use as experimental adjuvants for vaccination of cancer…”
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Genomic and transcriptomic landscape of conjunctival melanoma by Cisarova, Katarina, Folcher, Marc, El Zaoui, Ikram, Pescini-Gobert, Rosanna, Peter, Virginie G, Royer-Bertrand, Beryl, Zografos, Leonidas, Schalenbourg, Ann, Nicolas, Michael, Rimoldi, Donata, Leyvraz, Serge, Riggi, Nicolò, Moulin, Alexandre P, Rivolta, Carlo

“…Conjunctival melanoma (CJM) is a rare but potentially lethal and highly-recurrent cancer of the eye. Similar to cutaneous melanoma (CM), it originates from…”
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Extended co-expression of inhibitory receptors by human CD8 T-cells depending on differentiation, antigen-specificity and anatomical localization by Baitsch, Lukas, Legat, Amandine, Barba, Leticia, Fuertes Marraco, Silvia A, Rivals, Jean-Paul, Baumgaertner, Petra, Christiansen-Jucht, Céline, Bouzourene, Hanifa, Rimoldi, Donata, Pircher, Hanspeter, Rufer, Nathalie, Matter, Maurice, Michielin, Olivier, Speiser, Daniel E

“…Inhibitory receptors mediate CD8 T-cell hyporesponsiveness against cancer and infectious diseases. PD-1 and CTLA-4 have been extensively studied, and blocking…”
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UV light signature in conjunctival melanoma; not only skin should be protected from solar radiation by Rivolta, Carlo, Royer-Bertrand, Beryl, Rimoldi, Donata, Schalenbourg, Ann, Zografos, Leonidas, Leyvraz, Serge, Moulin, Alexandre

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Increased plasticity of the stiffness of melanoma cells correlates with their acquisition of metastatic properties by Weder, Gilles, PhD, Hendriks-Balk, Mariëlle C., PhD, Smajda, Rita, PhD, Rimoldi, Donata, PhD, Liley, Martha, PhD, Heinzelmann, Harry, PhD, Meister, André, PhD, Mariotti, Agnese, PhD

“…Abstract The stiffness of tumor cells varies during cancer progression. In particular, metastatic carcinoma cells analyzed by Atomic Force Microscopy (AFM)…”
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TLR3 as a Biomarker for the Therapeutic Efficacy of Double-stranded RNA in Breast Cancer by SALAUN, Bruno, ZITVOGEL, Laurence, GOUBAR, Aicha, LEBECQUE, Serge, PIERRES, Michel, RIMOLDI, Donata, ROMERO, Pedro, ANDRE, Fabrice, ASSELIN-PATUREL, Carine, MOREL, Yannis, CHEMIN, Karine, DUBOIS, Clarisse, MASSACRIER, Catherine, CONFORTI, Rosa, PIERRE CHENARD, Marie, SABOURIN, Jean-Christophe

“…The discovery of a targeted therapeutic compound along with its companion predictive biomarker is a major goal of clinical development for a personalized…”
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Broad and Conserved Immune Regulation by Genetically Heterogeneous Melanoma Cells by Neubert, Natalie J, Tillé, Laure, Barras, David, Soneson, Charlotte, Baumgaertner, Petra, Rimoldi, Donata, Gfeller, David, Delorenzi, Mauro, Fuertes Marraco, Silvia A, Speiser, Daniel E

“…Although mutations drive cancer, it is less clear to what extent genetic defects control immune mechanisms and confer resistance to T-cell-based immunotherapy…”
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Pattern and clinical significance of cancer‐testis gene expression in head and neck squamous cell carcinoma by Cuffel, Cyril, Rivals, Jean‐Paul, Zaugg, Yannick, Salvi, Suzanne, Seelentag, Walter, Speiser, Daniel E., Liénard, Danielle, Monnier, Philippe, Romero, Pedro, Bron, Luc, Rimoldi, Donata

“…Cancer‐testis (CT) antigens comprise families of tumor‐associated antigens that are immunogenic in patients with various cancers. Their restricted expression…”
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Nanosensors for cancer detection by Huber, François, Lang, Hans Peter, Zhang, Jiayun, Rimoldi, Donata, Gerber, Christoph

“…Cancer is a major burden in today's society and one of the leading causes of death in industrialised countries. Various avenues for the detection of cancer…”
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A Well-Controlled Experimental System to Study Interactions of Cytotoxic T Lymphocytes with Tumor Cells by Neubert, Natalie J, Soneson, Charlotte, Barras, David, Baumgaertner, Petra, Rimoldi, Donata, Delorenzi, Mauro, Fuertes Marraco, Silvia A, Speiser, Daniel E

“…While T cell-based immunotherapies are steadily improving, there are still many patients who progress, despite T cell-infiltrated tumors. Emerging evidence…”
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Network-guided analysis of genes with altered somatic copy number and gene expression reveals pathways commonly perturbed in metastatic melanoma by Valsesia, Armand, Rimoldi, Donata, Martinet, Danielle, Ibberson, Mark, Benaglio, Paola, Quadroni, Manfredo, Waridel, Patrice, Gaillard, Muriel, Pidoux, Mireille, Rapin, Blandine, Rivolta, Carlo, Xenarios, Ioannis, Simpson, Andrew J G, Antonarakis, Stylianos E, Beckmann, Jacques S, Jongeneel, C Victor, Iseli, Christian, Stevenson, Brian J

“…Cancer genomes frequently contain somatic copy number alterations (SCNA) that can significantly perturb the expression level of affected genes and thus disrupt…”
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Inhibition of death receptor signals by cellular FLIP by Tschopp, Jürg, Irmler, Martin, Thome, Margot, Hahne, Michael, Schneider, Pascal, Hofmann, Kay, Steiner, Véronique, Bodmer, Jean-Luc, Schröter, Michael, Burns, Kim, Mattmann, Chantal, Rimoldi, Donata, French, Lars E

“…The widely expressed protein Fas is a member of the tumour necrosis factor receptor family which can trigger apoptosis. However, Fas surface expression does…”
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E3 ubiquitin ligase Itch regulates sorting nexin 9 through an unconventional substrate recognition domain by Baumann, Claudia, Lindholm, Cecilia K, Rimoldi, Donata, Lévy, Frédéric

“…The level of intracellular proteins is mainly regulated through modifications by ubiquitin ligases that target them for degradation. Members of the NEDD4…”
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APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth by Hahne, M, Kataoka, T, Schröter, M, Hofmann, K, Irmler, M, Bodmer, J L, Schneider, P, Bornand, T, Holler, N, French, L E, Sordat, B, Rimoldi, D, Tschopp, J

“…Members of the tumor necrosis factor (TNF) family induce pleiotropic biological responses, including cell growth, differentiation, and even death. Here we…”
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Long-Term Protective Effect of Mature DC-LAMP+ Dendritic Cell Accumulation in Sentinel Lymph Nodes Containing Micrometastatic Melanoma by ELLIOTT, Bruce, SCOLYER, Richard A, TESTORI, Alessandro, EGGERMONT, Alexander, MACKIE, Rona, ROBERT, Caroline, COOK, Martin, THOMPSON, John F, ANGEVIN, Eric, SPATZ, Alain, SUCIU, Stefan, LEBECQUE, Serge, RIMOLDI, Donata, GUGERLI, Oliver, MUSAT, Elena, SHARMA, Raghwa N, LIENARD, Danielle, KEILHOLZ, Ulrich

“…Purpose: In a previous immunohistochemical study of dendritic cells (DC) in sentinel lymph nodes (SLN) draining regressing melanomas, we found that the…”
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Frequent MAGE mutations in human melanoma by Caballero, Otavia L, Zhao, Qi, Rimoldi, Donata, Stevenson, Brian J, Svobodová, Suzanne, Devalle, Sylvie, Röhrig, Ute F, Pagotto, Anna, Michielin, Olivier, Speiser, Daniel, Wolchok, Jedd D, Liu, Cailian, Pejovic, Tanja, Odunsi, Kunle, Brasseur, Francis, Van den Eynde, Benoit J, Old, Lloyd J, Lu, Xin, Cebon, Jonathan, Strausberg, Robert L, Simpson, Andrew J

“…Cancer/testis (CT) genes are expressed only in the germ line and certain tumors and are most frequently located on the X-chromosome (the CT-X genes). Amongst…”
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Endothelin receptor B inhibition triggers apoptosis and enhances angiogenesis in melanomas by LAHAV, Ronit, SUVA, Mario-Luca, RIMOLDI, Donata, PATTERSON, Paul H, STAMENKOVIC, Ivan

“…Endothelin receptor B (ETRB or EDNRB) is overexpressed in most human melanomas and is proposed to provide a marker of melanoma progression. We have shown…”
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Antigenicity and immunogenicity of Melan-A/MART-1 derived peptides as targets for tumor reactive CTL in human melanoma by Romero, Pedro, Valmori, Danila, Pittet, Mikael J., Zippelius, Alfred, Rimoldi, Donata, Lévy, Frederic, Dutoit, Valérie, Ayyoub, Maha, Rubio-Godoy, Verena, Michielin, Olivier, Guillaume, Philippe, Batard, Pascal, Luescher, Immanuel F., Lejeune, Ferdy, Liénard, Danielle, Rufer, Nathalie, Dietrich, Pierre-Yves, Speiser, Daniel E., Cerottini, Jean-Charles

“…Some cancer patients mount spontaneous T‐ and B‐cell responses against their tumor cells. Autologous tumor reactive CD8 cytolytic T lymphocyte (CTL) and CD4…”
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Expression of the Apoptosis Inhibitor Protease Inhibitor 9 Predicts Clinical Outcome in Vaccinated Patients with Stage III and IV Melanoma by VAN HOUDT, Inge S, OUDEJANS, Joost J, MEIJER, Chris J. L. M, KUMMER, Jean A, VAN DEN EERTWEGH, Alfonsus J. M, BAARS, Arnold, VOS, Wim, BLADERGROEN, Bellinda A, RIMOLDI, Donata, MURIS, Jettie J. F, HOOIJBERG, Erik, GUNDY, Chad M

“…Purpose: There have been reports of successful treatment of metastatic melanoma patients with active specific immunotherapy (ASI) using irradiated autologous…”
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Ubiquitylation of a melanosomal protein by HECT-E3 ligases serves as sorting signal for lysosomal degradation by Lévy, Frédéric, Muehlethaler, Katja, Salvi, Suzanne, Peitrequin, Anne-Lise, Lindholm, Cecilia K, Cerottini, Jean-Charles, Rimoldi, Donata

“…The production of pigment by melanocytic cells of the skin involves a series of enzymatic reactions that take place in specialized organelles called…”
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