Serum fetuin-A levels inversely correlate with the severity of arterial calcification in patients with chronic lower extremity atherosclerosis without renal disease

Fetuin-A is a hepatic glycoprotein that inhibits extraosseous calcification. Lower serum fetuin-A concentration was associated with severe arterial calcification in patients with end stage renal disease. We evaluated the association of serum fetuin-A levels and the severity of atherosclerosis in pat...

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Bibliographic Details
Published in:	International angiology Vol. 30; no. 5; p. 474
Main Authors:	Szeberin, Z, Fehérvári, M, Krepuska, M, Apor, A, Rimely, E, Sarkadi, H, Széplaki, G, Prohászka, Z, Kalabay, L, Acsády, G
Format:	Journal Article
Language:	English
Published:	Italy 01-10-2011
Subjects:	Aged alpha-2-HS-Glycoprotein - analysis Ankle Brachial Index Atherosclerosis - blood Atherosclerosis - diagnostic imaging Biomarkers - blood Calcinosis - blood Calcinosis - diagnostic imaging Chronic Disease Cross-Sectional Studies Down-Regulation Female Humans Hungary Logistic Models Lower Extremity - blood supply Male Middle Aged Odds Ratio Predictive Value of Tests Prognosis Radiography Risk Assessment Risk Factors Severity of Illness Index Ultrasonography, Doppler
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Summary:	Fetuin-A is a hepatic glycoprotein that inhibits extraosseous calcification. Lower serum fetuin-A concentration was associated with severe arterial calcification in patients with end stage renal disease. We evaluated the association of serum fetuin-A levels and the severity of atherosclerosis in patients with peripheral vascular disease having normal renal function. In this cross-sectional study among 93 chronic atherosclerotic patients with lower extremity vascular disease, systemic atherosclerosis and calcification was assessed by ultrasound (carotid intima-media thickness/IMT/, calcification at the abdominal aorta, carotid and femoral bifurcations, aortic and mitral valves) and angiography (Bollinger score). Standard serum markers of inflammation, diabetes, renal function, ankle-brachial indexes and traditional risk factors for atherosclerosis were noted and Fontaine classification was applied for the severity of symptoms. The patients mean (SD) age was 59.95 (7.61) years, 78% were men, 35% had diabetes. Serum fetuin-A level showed significant negative correlation with ultrasound calcification score (P=0.018, r=-0.257) and Bollinger angiographic score (P=0.035, r=-0.347). Fetuin-A did not correlate with IMT or Fontaine classification. Fetuin-A also showed significant correlation with albumin, transferrin and hemoglobin A1c (r=0.287, 0.305 and 0.219, respectively at P<0.05). Logistic regression analysis confirmed the association between fetuin-A and calcification score (OR: 3.03, CI: 1.05-8.7), P=0.039) independent of traditional risk factors. Our data show that serum fetuin-A levels inversely correlate with the severity of atherosclerosis in nonuremic patients with symptomatic chronic lower limb ischemia. These data support a putative protective role for fetuin-A in the development of arterial calcification.
ISSN:	1827-1839