Search Results - "Riley, Misha"

Evidence for brain glial activation in chronic pain patients by Loggia, Marco L, Chonde, Daniel B, Akeju, Oluwaseun, Arabasz, Grae, Catana, Ciprian, Edwards, Robert R, Hill, Elena, Hsu, Shirley, Izquierdo-Garcia, David, Ji, Ru-Rong, Riley, Misha, Wasan, Ajay D, Zürcher, Nicole R, Albrecht, Daniel S, Vangel, Mark G, Rosen, Bruce R, Napadow, Vitaly, Hooker, Jacob M

“…Although substantial evidence has established that microglia and astrocytes play a key role in the establishment and maintenance of persistent pain in animal…”
Get full text

PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia by Gilbert, Tonya M, Zürcher, Nicole R, Wu, Christine J, Bhanot, Anisha, Hightower, Baileigh G, Kim, Minhae, Albrecht, Daniel S, Wey, Hsiao-Ying, Schroeder, Frederick A, Rodriguez-Thompson, Anais, Morin, Thomas M, Hart, Kamber L, Pellegrini, Amelia M, Riley, Misha M, Wang, Changning, Stufflebeam, Steven M, Haggarty, Stephen J, Holt, Daphne J, Loggia, Marco L, Perlis, Roy H, Brown, Hannah E, Roffman, Joshua L, Hooker, Jacob M

“…Patients with schizophrenia (SCZ) experience chronic cognitive deficits. Histone deacetylases (HDACs) are enzymes that regulate cognitive circuitry; however,…”
Get full text

HDAC6 Brain Mapping with [18F]Bavarostat Enabled by a Ru-Mediated Deoxyfluorination by Strebl, Martin G, Campbell, Arthur J, Zhao, Wen-Ning, Schroeder, Frederick A, Riley, Misha M, Chindavong, Peter S, Morin, Thomas M, Haggarty, Stephen J, Wagner, Florence F, Ritter, Tobias, Hooker, Jacob M

“…Histone deacetylase 6 (HDAC6) function and dysregulation have been implicated in the etiology of certain cancers and more recently in central nervous system…”
Get full text

Feasibility of common, enjoyable game play for assessing daily cognitive functioning in older adults by Schwab, Nadine, Wu, Chao-Yi, Galler, Jake, DeRamus, Thomas, Ford, Abaigeal, Gerber, Jessica, Kitchen, Robert, Rashid, Barnaly, Riley, Misha, Sather, Lauren, Wang, Xifeng, Young, Cathrine, Yang, Liuqing, Dodge, Hiroko H., Arnold, Steven E.

“…Background Frequent digital monitoring of cognition is a promising approach for assessing endpoints in prevention and treatment trials of Alzheimer’s disease…”
Get full text

AKT Kinase Activity Is Required for Lithium to Modulate Mood-Related Behaviors in Mice by PAN, Jen Q, LEWIS, Michael C, NEVE, Rachael L, BIECHELE, Travis L, MOON, Randall T, SCOLNICK, Edward M, PETRYSHEN, Tracey L, HAGGARTY, Stephen J, KETTERMAN, Josh K, CLORE, Elizabeth L, RILEY, Misha, RICHARDS, Keenan R, BERRY-SCOTT, Erin, XIULIN LIU, WAGNER, Florence F, HOLSON, Edward B

“…Bipolar disorder (BP) is a debilitating psychiatric disorder, affecting ∼2% of the worldwide population, for which the etiological basis, pathogenesis, and…”
Get full text

A Fast-Binding, Functionally Reversible, COX‑2 Radiotracer for CNS PET Imaging by Placzek, Michael S., Wilton, Daniel K., Weïwer, Michel, Manter, Mariah A., Reid, Sarah E., Meyer, Christopher J., Campbell, Arthur J., Bajrami, Besnik, Bigot, Antoine, Bricault, Sarah, Fayet, Agathe, Frouin, Arnaud, Gergits, Frederick, Gupta, Mehak, Jiang, Wei, Melanson, Michelle, Romano, Chiara D., Riley, Misha M., Wang, Jessica M., Wey, Hsiao-Ying, Wagner, Florence F., Stevens, Beth, Hooker, Jacob M.

“…Cyclooxygenase-2 (COX-2) is an enzyme that plays a pivotal role in peripheral inflammation and pain via the prostaglandin pathway. In the central nervous…”
Get full text

Nasal neuron PET imaging quantifies neuron generation and degeneration by Van de Bittner, Genevieve C, Riley, Misha M, Cao, Luxiang, Ehses, Janina, Herrick, Scott P, Ricq, Emily L, Wey, Hsiao-Ying, O'Neill, Michael J, Ahmed, Zeshan, Murray, Tracey K, Smith, Jaclyn E, Wang, Changning, Schroeder, Frederick A, Albers, Mark W, Hooker, Jacob M

“…Olfactory dysfunction is broadly associated with neurodevelopmental and neurodegenerative diseases and predicts increased mortality rates in healthy…”
Get full text

FDG-PET imaging reveals local brain glucose utilization is altered by class I histone deacetylase inhibitors by Schroeder, Frederick A., Chonde, Daniel B., Riley, Misha M., Moseley, Christian K., Granda, Michael L., Wilson, Colin M., Wagner, Florence F., Zhang, Yan-Ling, Gale, Jennifer, Holson, Edward B., Haggarty, Stephen J., Hooker, Jacob M.

“…•Rats were treated with histone deacetylase (HDAC) inhibitors for seven days.•The two inhibitors used were selective for a subset of class I HDAC…”
Get full text

OLFACTORY SENSORY NEURON MONITORING IN ALZHEIMER’S DISEASE: TOWARD HUMAN TRANSLATION OF A PET IMAGING AGENT by Van de Bittner, Genevieve C, Riley, Misha M, Cao, Luxiang, Ehses, Janina, Neelamegam, Ramesh, Albers, Mark, Hooker, Jacob M, Wey, Hsiao-Ying

Get full text

OLFACTORY SENSORY NEURON MONITORING IN ALZHEIMER’S DISEASE: TOWARD HUMAN TRANSLATION OF A PET IMAGING AGENT by Van de Bittner, Genevieve C, Riley, Misha M, Cao, Luxiang, Ehses, Janina, Wey, Hsiao-Ying, Neelamegam, Ramesh, Albers, Mark, Hooker, Jacob M

Get full text

Evaluating the biological variability of blood‐based biomarkers for use in clinical trials by Trombetta, Bianca A., Allen, Shona W., El‐Mufti, Leena H., Riley, Misha M., Ramirez, Christopher E., Weik, Molly, Carlyle, Becky C., Kivisäkk, Pia, Arnold, Steven E.

“…Background Blood‐based biomarkers offer the possibility of inexpensive, minimally invasive, and accessible diagnostic tools for Alzheimer’s Disease (AD). In…”
Get full text

Using Proteomics Analysis to Identify Cerebrospinal Fluid Biomarkers in Normal Pressure Hydrocephalus by LaCasse, Kathryn, de Geus, Matthijs B, Trombetta, Bianca A., Ramirez, Christopher E., El‐Mufti, Leena H., Riley, Misha M., McManus, Alison J., Wills, Anne‐Marie, Kivisäkk, Pia, Carlyle, Becky C., Arnold, Steven E.

“…Background Normal Pressure Hydrocephalus (NPH) is a neurological condition where there is enlarged ventricular size with normal opening pressure at lumbar…”
Get full text

A multimodal pilot study of default mode network (DMN) connectivity across the lifespan in healthy volunteers using functional imaging, CSF, and plasma Alzheimer's disease biomarkers by Shapiro, Noah L, Galler, Jake A, Trombetta, Bianca A., LaCasse, Kathryn, Ramirez, Christopher E., Riley, Misha M., Williams, Victoria J., Kivisäkk, Pia, Salat, David H, Rashid, Barnaly, Arnold, Steven E.

“…Background Normal aging is associated with decreased functional connectivity (FC) in the brain’s default mode network (DMN). Additionally, cerebral burden of…”
Get full text

Identification and Prioritization of PET Neuroimaging Targets for Microglial Phenotypes Associated with Microglial Activity in Alzheimer’s Disease by Bartolo, Nicole D., Mortimer, Niall, Manter, Mariah A., Sanchez, Nicholas, Riley, Misha, O’Malley, Tiernan T., Hooker, Jacob M.

“…Activation of microglial cells accompanies the progression of many neurodegenerative disorders, including Alzheimer’s disease (AD). Development of molecular…”
Get full text

A pilot multiple crossover, randomized controlled trial of methylphenidate in mild cognitive impairment using standardized tests and daily brain games to track cognition: Neuropsychiatry and behavioral neurology/treatment development and clinical trials by DesRuisseaux, Libby A., Williams, Victoria J., McManus, Alison J., Gupta, Anoopum S., Bolling, Anna M., Schwab, Nadine A., Riley, Misha M., Carlyle, Becky C., Azami, Hamed, Gerber, Jessica A., Betensky, Rebecca A., Arnold, Steven E.

“…Abstract Background Conventional clinical trial design in AD and AD‐related disorders (ADRD) is the parallel‐group randomized controlled trial. However this…”
Get full text

A pilot multiple crossover, randomized controlled trial of methylphenidate in mild cognitive impairment using standardized tests and daily brain games to track cognition by DesRuisseaux, Libby A., Williams, Victoria J., McManus, Alison J., Gupta, Anoopum S., Bolling, Anna M., Schwab, Nadine A., Riley, Misha M., Carlyle, Becky C., Azami, Hamed, Gerber, Jessica A., Betensky, Rebecca A., Arnold, Steven E.

“…Background Conventional clinical trial design in AD and AD‐related disorders (ADRD) is the parallel‐group randomized controlled trial. However this design…”
Get full text

CN133, a Novel Brain-Penetrating Histone Deacetylase Inhibitor, Hampers Tumor Growth in Patient-Derived Pediatric Posterior Fossa Ependymoma Models by Antonelli, Roberta, Jiménez, Carlos, Riley, Misha, Servidei, Tiziana, Riccardi, Riccardo, Soriano, Aroa, Roma, Josep, Martínez-Saez, Elena, Martini, Maurizio, Ruggiero, Antonio, Moreno, Lucas, Sánchez de Toledo, Josep, Gallego, Soledad, Bové, Jordi, Hooker, Jacob M., Segura, Miguel F.

“…Pediatric ependymoma (EPN) is a highly aggressive tumor of the central nervous system that remains incurable in 40% of cases. In children, the majority of…”
Get full text

O1‐06‐06: Olfactory Sensory Neuron Monitoring in Alzheimer’s Disease: Toward Human Translation of a Pet Imaging Agent by Van de Bittner, Genevieve C., Riley, Misha M., Cao, Luxiang, Ehses, Janina, Neelamegam, Ramesh, Albers, Mark, Hooker, Jacob M., Wey, Hsiao-Ying

Get full text

IC‐P‐166: Olfactory Sensory Neuron Monitoring in Alzheimer’s Disease: Toward Human Translation of a Pet Imaging Agent by Van de Bittner, Genevieve C., Riley, Misha M., Cao, Luxiang, Ehses, Janina, Wey, Hsiao-Ying, Neelamegam, Ramesh, Albers, Mark, Hooker, Jacob M.

Get full text

Class I HDAC imaging using [3H]CI-994 autoradiography by Wang, Yajie, Zhang, Yan-Ling, Hennig, Krista, Gale, Jennifer P., Hong, Yijia, Cha, Anna, Riley, Misha, Wagner, Florence, Haggarty, Stephen J., Holson, Edward, Hooker, Jacob

“…[ 3 H]CI-994, a radioactive isotopologue of the benzamide CI-994, a class I histone deacetylase inhibitor (HDACi), was evaluated as an autoradiography probe…”
Get full text