Search Results - "Riley, Kent"

Current status of boron neutron capture therapy of high grade gliomas and recurrent head and neck cancer by Barth, Rolf F, Vicente, M Graca H, Harling, Otto K, Kiger, 3rd, W S, Riley, Kent J, Binns, Peter J, Wagner, Franz M, Suzuki, Minoru, Aihara, Teruhito, Kato, Itsuro, Kawabata, Shinji

“…Boron neutron capture therapy (BNCT) is a biochemically targeted radiotherapy based on the nuclear capture and fission reactions that occur when…”
Get full text

Quantum Dot-Organic Polymer Composite Materials for Radiation Detection and Imaging by Lawrence, W. G., Thacker, S., Palamakumbura, S., Riley, K. J., Nagarkar, V. V.

“…Colloidal semiconductor nanocrystals exhibit physical properties that are characteristic of intermediate size scales between molecular states and solid state…”
Get full text

Molecular Targeting and Treatment of Composite EGFR and EGFRvIII-Positive Gliomas Using Boronated Monoclonal Antibodies by Yang, Weilian, Wu, Gong, Barth, Rolf F, Swindall, Michele R, Bandyopadhyaya, Achintya K, Tjarks, Werner, Tordoff, Kevin, Moeschberger, Melvin, Sferra, Thomas J, Binns, Peter J, Riley, Kent J, Ciesielski, Michael J, Fenstermaker, Robert A, Wikstrand, Carol J

“…Purpose: The purpose of the present study was to evaluate the anti–epidermal growth factor receptor (EGFR) monoclonal antibody (mAb), cetuximab, (IMC-C225) and…”
Get full text

Molecular Targeting and Treatment of an Epidermal Growth Factor Receptor–Positive Glioma Using Boronated Cetuximab by GONG WU, WEILIAN YANG, MING YANG, CHRISTOFORIDIS, Gregory A, SFERRA, Thomas J, BINNS, Peter J, RILEY, Kent J, CIESIELSKI, Michael J, FENSTERMAKER, Robert A, BARTH, Rolf F, KAWABATA, Shinji, SWINDALL, Michele, BANDYOPADHYAYA, Achintya K, TJARKS, Werner, KHORSANDI, Behrooz, BLUE, Thomas E, FERKETICH, Amy K

“…Purpose: The purpose of the present study was to evaluate the anti–epidermal growth factor monoclonal antibody (mAb) cetuximab (IMC-C225) as a delivery agent…”
Get full text

Thymidine kinase 1 as a molecular target for boron neutron capture therapy of brain tumors by Barth, Rolf F, Yang, Weilian, Wu, Gong, Swindall, Michele, Byun, Youngjoo, Narayanasamy, Sureshbabu, Tjarks, Werner, Tordoff, Kevin, Moeschberger, Melvin L, Eriksson, Staffan, Binns, Peter J, Riley, Kent J

“…The purpose of the present study was to evaluate the effectiveness of a 3-carboranyl thymidine analogue (3CTA),…”
Get full text

Evaluation of TK1 targeting carboranyl thymidine analogs as potential delivery agents for neutron capture therapy of brain tumors by Barth, Rolf F., Yang, Weilian, Nakkula, Robin J., Byun, Youngjoo, Tjarks, Werner, Chu Wu, Lai, Binns, Peter J., Riley, Kent J.

“…In this report we describe studies with N5-2OH, a carboranyl thymidine analog (CTA), which is a substrate for thymidine kinase 1 (TK1), using the F98 rat…”
Get full text

Convection enhanced delivery of boronated EGF as a molecular targeting agent for neutron capture therapy of brain tumors by Yang, Weilian, Barth, Rolf F., Wu, Gong, Huo, Tianyao, Tjarks, Werner, Ciesielski, Michael, Fenstermaker, Robert A., Ross, Brain D., Wikstrand, Carol J., Riley, Kent J., Binns, Peter J.

“…In the present study, we have evaluated a boronated dendrimer-epidermal growth factor (BD-EGF) bioconjugate as a molecular targeting agent for boron neutron…”
Get full text

Convection enhanced delivery of carboranylporphyrins for neutron capture therapy of brain tumors by Kawabata, Shinji, Yang, Weilian, Barth, Rolf F., Wu, Gong, Huo, Tianyao, Binns, Peter J., Riley, Kent J., Ongayi, Owendi, Gottumukkala, Vijay, Vicente, M. Graça H.

“…Boron neutron capture therapy (BNCT) is based on the nuclear capture and fission reactions that occur when non-radioactive 10 B is irradiated with low energy…”
Get full text

Molecular Targeting and Treatment of EGFRvIII-Positive Gliomas Using Boronated Monoclonal Antibody L8A4 by Yang, Weilian, Barth, Rolf F, Wu, Gong, Kawabata, Shinji, Sferra, Thomas J, Bandyopadhyaya, Achintya K, Tjarks, Werner, Ferketich, Amy K, Moeschberger, Melvin L, Binns, Peter J, Riley, Kent J, Coderre, Jeffrey A, Ciesielski, Michael J, Fenstermaker, Robert A, Wikstrand, Carol J

“…Purpose: The purpose of the present study was to evaluate a boronated EGFRvIII-specific monoclonal antibody, L8A4, for boron neutron capture therapy (BNCT) of…”
Get full text

No Significant Endothelial Apoptosis in the Radiation-Induced Gastrointestinal Syndrome by Schuller, Bradley W., B.A, Rogers, Arlin B., D.V.M., Ph.D, Cormier, Kathleen S., B.S, Riley, Kent J., Ph.D, Binns, Peter J., Ph.D, Julius, Richard, B.S, Hawthorne, M. Frederick, Ph.D, Coderre, Jeffrey A., Ph.D

“…Purpose: This report addresses the incidence of vascular endothelial cell apoptosis in the mouse small intestine in relation to the radiation-induced…”
Get full text

Single Event Effects in Power MOSFETs Due to the Secondary Neutron Environment in a Proton Therapy Center by Cascio, E. W., Riley, K. J., McCormack, J., Flanagan, R.

“…Secondary neutron induced single event burnouts (SEB) in power MOSFETs to be installed in an X-ray generator located in a proton therapy treatment vault are…”
Get full text

Selective Irradiation of the Vascular Endothelium Has No Effect on the Survival of Murine Intestinal Crypt Stem Cells by Schuller, Bradley W., Binns, Peter J., Riley, Kent J., Ma, Ling, Hawthorne, M. Frederick, Coderre, Jeffrey A.

“…The possible role of vascular endothelial cell damage in the loss of intestinal crypt stem cells and the subsequent development of the gastrointestinal (GI)…”
Get full text

Functional and Histological Changes in Rat Lung after Boron Neutron Capture Therapy by Kiger, Jingli Liu, Kiger, W. S., Riley, Kent J., Binns, Peter J., Patel, Hemant, Hopewell, John W., Harling, Otto K., Busse, Paul M., Coderre, Jeffrey A.

“…Kiger, J. L., Kiger, W. S., III, Riley, K. J., Binns, P. J., Patel, H., Hopewell, J. W., Harling, O. K., Busse, P. M. and Coderre, J. A. Functional and…”
Get full text

Boron Neutron Capture Therapy: Cellular Targeting of High Linear Energy Transfer Radiation by Coderre, Jeffrey A., Turcotte, Julie C., Riley, Kent J., Binns, Peter J., Harling, Otto K., Kiger, W. S.

“…Boron neutron capture therapy (BNCT) is based on the preferential targeting of tumor cells with10 B and subsequent activation with thermal neutrons to produce…”
Get full text

Comparison of intracerebral delivery of carboplatin and photon irradiation with an optimized regimen for boron neutron capture therapy of the F98 rat glioma by Barth, Rolf F., Yang, Weilian, Huo, Tianyao, Riley, Kent J., Binns, Peter J., Grecula, John C., Gupta, Nilendu, Rousseau, Julia, Elleaume, Hélène

“…In this report we have summarized our studies to optimize the delivery of boronophenylalanine (BPA) and sodium borocaptate (BSH) for boron neutron capture…”
Get full text

Neutron capture therapy of epidermal growth factor (+) gliomas using boronated cetuximab (IMC-C225) as a delivery agent by Barth, Rolf F, Wu, Gong, Yang, Weilian, Binns, Peter J, Riley, Kent J, Patel, Hemant, Coderre, Jeffrey A, Tjarks, Werner, Bandyopadhyaya, A.K, Thirumamagal, B.T.S, Ciesielski, Michael J, Fenstermaker, Robert A

“…Cetuximab (IMC-C225) is a monoclonal antibody directed against both the wild-type and mutant vIII isoform of the epidermal growth factor receptor (EGFR). The…”
Get full text

Treatment planning and dosimetry for the Harvard-MIT Phase I clinical trial of cranial neutron capture therapy by Palmer, Matthew R, Goorley, J Timothy, Kiger, W S, Busse, Paul M, Riley, Kent J, Harling, Otto K, Zamenhof, Robert G

“…A Phase I trial of cranial neutron capture therapy (NCT) was conducted at Harvard-MIT. The trial was designed to determine maximum tolerated NCT radiation dose…”
Get more information

Improved dose targeting for a clinical epithermal neutron capture beam using optional (6)Li filtration by Binns, Peter J, Riley, Kent J, Ostrovsky, Yakov, Gao, Wei, Albritton, J Raymond, Kiger, 3rd, W S, Harling, Otto K

“…The aim of this study was to construct a (6)Li filter and to improve penetration of thermal neutrons produced by the fission converter-based epithermal neutron…”
Get full text

Energy- and time-resolved detection of prompt gamma-rays for proton range verification by Verburg, Joost M, Riley, Kent, Bortfeld, Thomas, Seco, Joao

“…In this work, we present experimental results of a novel prompt gamma-ray detector for proton beam range verification. The detection system features an…”
Get more information

Irradiation performance of polytetrafluoroethylene (Teflon ®) in a mixed fast neutron and gamma radiation field by Harling, Otto K, Kohse, Gordon E, Riley, Kent J

“…Samples of polytetrafluoroethylene have been irradiated with a mixed field of fast neutrons and gamma rays using the MIT Research Reactor. Dose levels from…”
Get full text