Dorsal clock networks drive temperature preference rhythms in Drosophila

Animals display a body temperature rhythm (BTR). Little is known about the mechanisms by which a rhythmic pattern of BTR is regulated and how body temperature is set at different times of the day. As small ectotherms, Drosophila exhibit a daily temperature preference rhythm (TPR), which generates BT...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 39; no. 2; p. 110668
Main Authors:	Chen, Shyh-Chi, Tang, Xin, Goda, Tadahiro, Umezaki, Yujiro, Riley, Abigail C., Sekiguchi, Manabu, Yoshii, Taishi, Hamada, Fumika N.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 12-04-2022
Subjects:	Animals anterior dorsal neurons 1 body temperature rhythms and Drosophila melanogaster circadian clock Circadian Rhythm - physiology circadian rhythms dorsal neurons 2 Drosophila - physiology Drosophila melanogaster Drosophila Proteins - genetics Neurons - physiology posterior dorsal neurons 1 Temperature temperature homeostasis temperature preference rhythms thermoregulation body temperature rhythms and Drosophila melanogaster posterior dorsal neurons 1 CP: Neuroscience anterior dorsal neurons 1 temperature homeostasis circadian rhythms circadian clock thermoregulation temperature preference rhythms dorsal neurons 2
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Summary:	Animals display a body temperature rhythm (BTR). Little is known about the mechanisms by which a rhythmic pattern of BTR is regulated and how body temperature is set at different times of the day. As small ectotherms, Drosophila exhibit a daily temperature preference rhythm (TPR), which generates BTR. Here, we demonstrate dorsal clock networks that play essential roles in TPR. Dorsal neurons 2 (DN2s) are the main clock for TPR. We find that DN2s and posterior DN1s (DN1ps) contact and the extent of contacts increases during the day and that the silencing of DN2s or DN1ps leads to a lower temperature preference. The data suggest that temporal control of the microcircuit from DN2s to DN1ps contributes to TPR regulation. We also identify anterior DN1s (DN1as) as another important clock for TPR. Thus, we show that the DN networks predominantly control TPR and determine both a rhythmic pattern and preferred temperatures. [Display omitted] •The DN2-DN1p microcircuit regulates the daytime TPR.•The silencing of DN2s or DN1ps leads to a lower temperature preference.•DN1as are the important clock neurons for TPR•The DN networks control a rhythmic pattern and a temperature setpoint of TPR The body temperature rhythm (BTR) is vital for maintaining homeostasis. Drosophila exhibit a daily temperature preference rhythm (TPR), which generates BTR. Chen et al. show that dorsal clock neurons in the brain form a time-dependent network and govern TPR by regulating a rhythmic pattern and a temperature setpoint.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 AUTHOR CONTRIBUTIONS Conceptualization, F.N.H., S.C.C., and X.T.; Methodology, F.N.H., S.C.C., and X.T.; Investigation, S.C.C., X.T., T.G., U.Y., A.C.R., and M.S.; Writing – Original Draft, F.N.H.; Writing – Review & Editing, S.C.C., X.T., and T.G.; Funding Acquisition, F.N.H. and Y.T.; Visualization, F.N.H., S.C.C., X.T., and T.G.; Resources, S.C.C., X.T., T.G., U.Y., A.C.R., and M.S.; Supervision, F.N.H. and Y.T.
ISSN:	2211-1247 2211-1247
DOI:	10.1016/j.celrep.2022.110668