Search Results - "Riksen, Joost A. G."

Temporal dynamics of gene expression in heat-stressed Caenorhabditis elegans by Jovic, Katharina, Sterken, Mark G, Grilli, Jacopo, Bevers, Roel P J, Rodriguez, Miriam, Riksen, Joost A G, Allesina, Stefano, Kammenga, Jan E, Snoek, L Basten

“…There is considerable insight into pathways and genes associated with heat-stress conditions. Most genes involved in stress response have been identified using…”
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Contribution of trans regulatory eQTL to cryptic genetic variation in C. elegans by Snoek, Basten L, Sterken, Mark G, Bevers, Roel P J, Volkers, Rita J M, Van't Hof, Arjen, Brenchley, Rachel, Riksen, Joost A G, Cossins, Andrew, Kammenga, Jan E

“…Cryptic genetic variation (CGV) is the hidden genetic variation that can be unlocked by perturbing normal conditions. CGV can drive the emergence of novel…”
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Mapping determinants of gene expression plasticity by genetical genomics in C. elegans by Li, Yang, Alvarez, Olga Alda, Gutteling, Evert W, Tijsterman, Marcel, Fu, Jingyuan, Riksen, Joost A G, Hazendonk, Esther, Prins, Pjotr, Plasterk, Ronald H A, Jansen, Ritsert C, Breitling, Rainer, Kammenga, Jan E

“…Recent genetical genomics studies have provided intimate views on gene regulatory networks. Gene expression variations between genetically different…”
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Transcriptional analysis of the response of C. elegans to ethanol exposure by Sterken, Mark G., van Wijk, Marijke H., Quamme, Elizabeth C., Riksen, Joost A. G., Carnell, Lucinda, Mathies, Laura D., Davies, Andrew G., Kammenga, Jan E., Bettinger, Jill C.

“…Ethanol-induced transcriptional changes underlie important physiological responses to ethanol that are likely to contribute to the addictive properties of the…”
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Transcriptome resilience predicts thermotolerance in Caenorhabditis elegans by Jovic, Katharina, Grilli, Jacopo, Sterken, Mark G, Snoek, Basten L, Riksen, Joost A G, Allesina, Stefano, Kammenga, Jan E

“…The detrimental effects of a short bout of stress can persist and potentially turn lethal, long after the return to normal conditions. Thermotolerance, which…”
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A heritable antiviral RNAi response limits Orsay virus infection in Caenorhabditis elegans N2 by Sterken, Mark G, Snoek, L Basten, Bosman, Kobus J, Daamen, Jikke, Riksen, Joost A G, Bakker, Jaap, Pijlman, Gorben P, Kammenga, Jan E

“…Orsay virus (OrV) is the first virus known to be able to complete a full infection cycle in the model nematode species Caenorhabditis elegans. OrV is…”
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A multi-parent recombinant inbred line population of C. elegans allows identification of novel QTLs for complex life history traits by Snoek, Basten L, Volkers, Rita J M, Nijveen, Harm, Petersen, Carola, Dirksen, Philipp, Sterken, Mark G, Nakad, Rania, Riksen, Joost A G, Rosenstiel, Philip, Stastna, Jana J, Braeckman, Bart P, Harvey, Simon C, Schulenburg, Hinrich, Kammenga, Jan E

“…The nematode Caenorhabditis elegans has been extensively used to explore the relationships between complex traits, genotypes, and environments. Complex traits…”
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Genome-wide gene expression analysis in response to organophosphorus pesticide chlorpyrifos and diazinon in C. elegans by Viñuela, Ana, Snoek, L Basten, Riksen, Joost A G, Kammenga, Jan E

“…Organophosphorus pesticides (OPs) were originally designed to affect the nervous system by inhibiting the enzyme acetylcholinesterase, an important regulator…”
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A Caenorhabditis elegans Wild Type Defies the Temperature-Size Rule Owing to a Single Nucleotide Polymorphism in tra-3 by Kammenga, J.E, Doroszuk, A, Riksen, J.A.G, Hazendonk, E, Spiridon, L, Petrescu, A.J, Tijsterman, M, Plasterk, R.H.A, Bakker, J

“…Ectotherms rely for their body heat on surrounding temperatures. A key question in biology is why most ectotherms mature at a larger size at lower…”
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Gene Expression Modifications by Temperature-Toxicants Interactions in Caenorhabditis elegans by Vinuela Rodriguez, A, Snoek, L.B, Riksen, J.A.G, Kammenga, J.E

“…Although organophosphorus pesticides (OP) share a common mode of action, there is increased awareness that they elicit a diverse range of gene expression…”
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The genetic architecture underlying body-size traits plasticity over different temperatures and developmental stages in Caenorhabditis elegans by Maulana, Muhammad I, Riksen, Joost A G, Snoek, Basten L, Kammenga, Jan E, Sterken, Mark G

“…Most ectotherms obey the temperature-size rule, meaning they grow larger in a colder environment. This raises the question of how the interplay between genes…”
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Punctuated Loci on Chromosome IV Determine Natural Variation in Orsay Virus Susceptibility of Caenorhabditis elegans Strains Bristol N2 and Hawaiian CB4856 by Sterken, Mark G, van Sluijs, Lisa, Wang, Yiru A, Ritmahan, Wannisa, Gultom, Mitra L, Riksen, Joost A G, Volkers, Rita J M, Snoek, L Basten, Pijlman, Gorben P, Kammenga, Jan E

“…Host-pathogen interactions play a major role in evolutionary selection and shape natural genetic variation. The genetically distinct strains, Bristol N2 and…”
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Determining Toxic Potencies of Water-Soluble Contaminants in Wastewater Influents and Effluent Using Gene Expression Profiling in C. elegans as a Bioanalytical Tool by Karengera, Antoine, Verburg, Ilse, Sterken, Mark G., Riksen, Joost A. G., Murk, Albertinka J., Dinkla, Inez J. T.

“…With chemical analysis, it is impossible to qualify and quantify the toxic potency of especially hydrophilic bioactive contaminants. In this study, we applied…”
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Genetic background modifies phenotypic and transcriptional responses in a C. elegans model of α-synuclein toxicity by Wang, Yiru A, Snoek, Basten L, Sterken, Mark G, Riksen, Joost A G, Stastna, Jana J, Kammenga, Jan E, Harvey, Simon C

“…Accumulation of protein aggregates are a major hallmark of progressive neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease…”
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Cryptic genetic variation of expression quantitative trait locus architecture revealed by genetic perturbation in Caenorhabditis elegans by van Wijk, Marijke H, Riksen, Joost A G, Elvin, Mark, Poulin, Gino B, Maulana, Muhammad I, Kammenga, Jan E, Snoek, Basten L, Sterken, Mark G

“…Abstract Genetic perturbation in different genetic backgrounds can cause a range of phenotypes within a species. These phenotypic differences can be the result…”
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Dissecting the eQTL Micro-Architecture in Caenorhabditis elegans by Sterken, Mark G, Bevers, Roel P J, Volkers, Rita J M, Riksen, Joost A G, Kammenga, Jan E, Snoek, Basten L

“…The study of expression quantitative trait loci (eQTL) using natural variation in inbred populations has yielded detailed information about the transcriptional…”
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Balancing Selection of the Intracellular Pathogen Response in Natural Caenorhabditis elegans Populations by van Sluijs, Lisa, Bosman, Kobus J, Pankok, Frederik, Blokhina, Tatiana, Wilten, Jop I H A, Te Molder, Dennie M, Riksen, Joost A G, Snoek, Basten L, Pijlman, Gorben P, Kammenga, Jan E, Sterken, Mark G

“…Genetic variation in host populations may lead to differential viral susceptibilities. Here, we investigate the role of natural genetic variation in the…”
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Selection and gene flow shape niche-associated variation in pheromone response by Lee, Daehan, Zdraljevic, Stefan, Cook, Daniel E., Frézal, Lise, Hsu, Jung-Chen, Sterken, Mark G., Riksen, Joost A. G., Wang, John, Kammenga, Jan E., Braendle, Christian, Félix, Marie-Anne, Schroeder, Frank C., Andersen, Erik C.

“…From quorum sensing in bacteria to pheromone signalling in social insects, chemical communication mediates interactions among individuals in local populations…”
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Ras/MAPK Modifier Loci Revealed by eQTL in Caenorhabditis elegans by Sterken, Mark G, van Bemmelen van der Plaat, Linda, Riksen, Joost A G, Rodriguez, Miriam, Schmid, Tobias, Hajnal, Alex, Kammenga, Jan E, Snoek, Basten L

“…The oncogenic Ras/MAPK pathway is evolutionarily conserved across metazoans. Yet, almost all our knowledge on this pathway comes from studies using single…”
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eQTL mapping in transgenic alpha-synuclein carrying Caenorhabditis elegans recombinant inbred lines by Huang, Yuqing, Wang, Yiru A, van Sluijs, Lisa, Vogels, Demi H J, Chen, Yuzhi, Tegelbeckers, Vivian I P, Schoonderwoerd, Steven, Riksen, Joost A G, Kammenga, Jan E, Harvey, Simon C, Sterken, Mark G

“…Protein aggregation of α-synuclein (αS) is a genetic and neuropathological hallmark of Parkinson's disease (PD). Studies in the model nematode Caenorhabditis…”
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