Search Results - "Rik Derynck"

Specificity, versatility, and control of TGF-β family signaling by Derynck, Rik, Budi, Erine H

“…Encoded in mammalian cells by 33 genes, the transforming growth factor-β (TGF-β) family of secreted, homodimeric and heterodimeric proteins controls the…”
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Molecular mechanisms of epithelial–mesenchymal transition by Lamouille, Samy, Xu, Jian, Derynck, Rik

“…Key Points The epithelial–mesenchymal transition (EMT) process results in the downregulation of epithelial, and activation of mesenchymal, cell characteristics…”
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Direct Activation of TACE-Mediated Ectodomain Shedding by p38 MAP Kinase Regulates EGF Receptor-Dependent Cell Proliferation by Xu, Pinglong, Derynck, Rik

“…Inflammatory stimuli activate ectodomain shedding of TNF-α, L-selectin, and other transmembrane proteins. We show that p38 MAP kinase, which is activated in…”
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Regulation of epithelial–mesenchymal and mesenchymal–epithelial transitions by microRNAs by Lamouille, Samy, Subramanyam, Deepa, Blelloch, Robert, Derynck, Rik

“…Epithelial–mesenchymal transition (EMT) and the reverse process, mesenchymal–epithelial transition (MET), are essential during development and in the…”
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Chronic TGF-β exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition by Katsuno, Yoko, Meyer, Dominique Stephan, Zhang, Ziyang, Shokat, Kevan M, Akhurst, Rosemary J, Miyazono, Kohei, Derynck, Rik

“…Tumors comprise cancer stem cells (CSCs) and their heterogeneous progeny within a stromal microenvironment. In response to transforming growth factor-β…”
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Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells by Lamouille, Samy, Judson, Robert L, Blelloch, Robert, Subramanyam, Deepa, Derynck, Rik, Liu, Jason Y, Bucay, Nathan

“…The embryonic stem cell-specific cell cycle-regulating (ESCC) family of microRNAs (miRNAs) enhances reprogramming of mouse embryonic fibroblasts to induced…”
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TACE activation by MAPK-mediated regulation of cell surface dimerization and TIMP3 association by Xu, Pinglong, Liu, Jianming, Sakaki-Yumoto, Masayo, Derynck, Rik

“…Ectodomain shedding mediated by tumor necrosis factor-α (TNF-α)-converting enzyme [TACE; also known as ADAM17 (a disintegrin and metalloproteinase 17)]…”
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Fibroblast-specific inhibition of TGF-β1 signaling attenuates lung and tumor fibrosis by Wei, Ying, Kim, Thomas J, Peng, David H, Duan, Dana, Gibbons, Don L, Yamauchi, Mitsuo, Jackson, Julia R, Le Saux, Claude J, Calhoun, Cheresa, Peters, Jay, Derynck, Rik, Backes, Bradley J, Chapman, Harold A

“…TGF-β1 signaling is a critical driver of collagen accumulation and fibrotic disease but also a vital suppressor of inflammation and epithelial cell…”
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Smad2 Is Essential for Maintenance of the Human and Mouse Primed Pluripotent Stem Cell State by Sakaki-Yumoto, Masayo, Liu, Jianming, Ramalho-Santos, Miguel, Yoshida, Nobuaki, Derynck, Rik

“…Human embryonic stem cells and mouse epiblast stem cells represent a primed pluripotent stem cell state that requires TGF-β/activin signaling. TGF-β and/or…”
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Arginine Methylation Initiates BMP-Induced Smad Signaling by Xu, Jian, Wang, A. Hongjun, Oses-Prieto, Juan, Makhijani, Kalpana, Katsuno, Yoko, Pei, Ming, Yan, Leilei, Zheng, Y. George, Burlingame, Alma, Brückner, Katja, Derynck, Rik

“…Kinase activation and substrate phosphorylation commonly form the backbone of signaling cascades. Bone morphogenetic proteins (BMPs), a subclass of TGF-β…”
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ShcA Protects against Epithelial-Mesenchymal Transition through Compartmentalized Inhibition of TGF-β-Induced Smad Activation by Muthusamy, Baby Periyanayaki, Budi, Erine H, Katsuno, Yoko, Lee, Matthew K, Smith, Susan M, Mirza, Amer M, Akhurst, Rosemary J, Derynck, Rik

“…Epithelial-mesenchymal transition (EMT) is a normal cell differentiation event during development and contributes pathologically to carcinoma and fibrosis…”
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New progress in roles of TGF-β signaling crosstalks in cellular functions, immunity and diseases by Gu, Shuchen, Derynck, Rik, Chen, Ye-Guang, Feng, Xin-Hua

“…The family of secreted dimeric proteins known as the Transforming Growth Factor-β (TGF-β) family plays a critical role in facilitating intercellular…”
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Stem cell antigen-1 enhances tumorigenicity by disruption of growth differentiation factor-10 (GDF10)-dependent TGF-β signaling by Upadhyay, Geeta, Yin, Yuzhi, Yuan, Hongyan, Li, Xin, Derynck, Rik, Glazer, Robert I., Brugge, Joan S.

“…Stem cell antigen (Sca)-1/Ly6A, a glycerophosphatidylinositol-linked surface protein, was found to be associated with murine stem cell-and progenitor…”
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BMP-9 balances endothelial cell fate by Derynck, Rik, Akhurst, Rosemary J.

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Bone Morphogenetic Protein and Retinoic Acid Signaling Cooperate to Induce Osteoblast Differentiation of Preadipocytes by Skillington, Jeremy, Choy, Lisa, Derynck, Rik

“…Mesenchymal cells can differentiate into osteoblasts, adipocytes, myoblasts, or chondroblasts. Whether mesenchymal cells that have initiated differentiation…”
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Pharmacologic inhibition of the TGF-beta type I receptor kinase has anabolic and anti-catabolic effects on bone by Mohammad, Khalid S, Chen, Carol G, Balooch, Guive, Stebbins, Elizabeth, McKenna, C Ryan, Davis, Holly, Niewolna, Maria, Peng, Xiang Hong, Nguyen, Daniel H N, Ionova-Martin, Sophi S, Bracey, John W, Hogue, William R, Wong, Darren H, Ritchie, Robert O, Suva, Larry J, Derynck, Rik, Guise, Theresa A, Alliston, Tamara

“…During development, growth factors and hormones cooperate to establish the unique sizes, shapes and material properties of individual bones. Among these,…”
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Enhanced TGF-β Signaling Contributes to the Insulin-Induced Angiogenic Responses of Endothelial Cells by Budi, Erine H., Mamai, Ons, Hoffman, Steven, Akhurst, Rosemary J., Derynck, Rik

“…Angiogenesis, the development of new blood vessels, is a key process in disease. We reported that insulin promotes translocation of transforming growth factor…”
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Epithelial plasticity, epithelial-mesenchymal transition, and the TGF-β family by Katsuno, Yoko, Derynck, Rik

“…Epithelial cells repress epithelial characteristics and elaborate mesenchymal characteristics to migrate to other locations and acquire new properties…”
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Identification of the GATA Factor TRPS1 as a Repressor of the Osteocalcin Promoter by Piscopo, Denise M., Johansen, Eric B., Derynck, Rik

“…A proteomic analysis of proteins bound to the osteocalcin OSE2 sequence of the mouse osteocalcin promoter identified TRPS1 as a regulator of osteocalcin…”
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Regulation of Smad Degradation and Activity by Smurf2, an E3 Ubiquitin Ligase by Zhang, Ying, Chang, Chenbei, Gehling, Daniel J., Hemmati-Brivanlou, Ali, Derynck, Rik

“…Smad proteins are key intracellular signaling effectors for the transforming growth factor-β superfamily of peptide growth factors. Following receptor-induced…”
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